{"id":"https://openalex.org/W4361950355","doi":"https://doi.org/10.1158/1078-0432.c.6520704.v1","title":"Data from Targeting Fibroblast Growth Factor Receptor Signaling Inhibits Prostate Cancer Progression","display_name":"Data from Targeting Fibroblast Growth Factor Receptor Signaling Inhibits Prostate Cancer Progression","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361950355","doi":"https://doi.org/10.1158/1078-0432.c.6520704.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6520704.v1","doi":"https://doi.org/10.1158/1078-0432.c.6520704.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6520704.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6520704.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100452846","display_name":"Shu Feng","orcid":"https://orcid.org/0000-0002-5372-4497","observed_orcids":["https://orcid.org/0000-0002-5372-4497"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shu Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101651164","display_name":"Longjiang Shao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Longjiang Shao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088471760","display_name":"Wendong Yu","orcid":"https://orcid.org/0000-0001-8958-6762","observed_orcids":["https://orcid.org/0000-0001-8958-6762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendong Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004197553","display_name":"Paul R. Gavine","orcid":"https://orcid.org/0000-0001-9582-4771","observed_orcids":["https://orcid.org/0000-0001-9582-4771"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Gavine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5066263660","display_name":"Michael Ittmann","orcid":"https://orcid.org/0000-0003-4802-0978","observed_orcids":["https://orcid.org/0000-0003-4802-0978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Ittmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12287","display_name":"Fibroblast Growth Factor Research","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fibroblast-growth-factor-receptor","display_name":"fibroblast growth factor receptor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/fgfr-signaling","display_name":"FGFR signaling","score":0.8659999966621399},{"id":"https://openalex.org/keywords/prostate-cancer-progression","display_name":"prostate cancer progression","score":0.9290000200271606},{"id":"https://openalex.org/keywords/fgfr1","display_name":"FGFR1","score":0.8169999718666077},{"id":"https://openalex.org/keywords/fgfr4","display_name":"FGFR4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.9010000228881836},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.578000009059906},{"id":"https://openalex.org/keywords/vcap-xenograft","display_name":"VCaP xenograft","score":0.9399999976158142},{"id":"https://openalex.org/keywords/fgfr-inhibitors","display_name":"FGFR inhibitors","score":0.6019999980926514}],"concepts":[{"id":"https://openalex.org/C82867764","wikidata":"https://www.wikidata.org/wiki/Q24780051","display_name":"Fibroblast growth factor receptor","level":4,"score":0.7846657037734985},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6366161108016968},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6156724691390991},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5275936722755432},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.4691181480884552},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.42882731556892395},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42376238107681274},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.40986236929893494},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3995858132839203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3565569519996643},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2723194658756256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1934797763824463},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10231223702430725},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6520704.v1","doi":"https://doi.org/10.1158/1078-0432.c.6520704.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6520704.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6520704.v1","doi":"https://doi.org/10.1158/1078-0432.c.6520704.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6520704.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2168346858","https://openalex.org/W2318756335","https://openalex.org/W2026721670","https://openalex.org/W2102174623","https://openalex.org/W4255341723","https://openalex.org/W2048154391","https://openalex.org/W2334968098","https://openalex.org/W4402689850","https://openalex.org/W1963579146","https://openalex.org/W2003793248"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Extensive":[2],"correlative":[3],"studies":[4,12],"in":[5,13,16,31,73,87,122,127,140,166,171,182,197,214,226],"human":[6],"prostate":[7,32,104,128,191,241],"cancer":[8,33,129,192],"as":[9,11],"well":[10],"vitro":[14,74,123],"and":[15,51,82,97,108,120,154,180,187,189,204,208,210],"mouse":[17],"models":[18],"indicate":[19],"that":[20],"fibroblast":[21],"growth":[22,203],"factor":[23],"receptor":[24],"(FGFR)":[25],"signaling":[26,66,96,158,232],"plays":[27],"an":[28,44,164],"important":[29],"role":[30],"progression.":[34],"In":[35],"this":[36,58],"study,":[37],"we":[38],"used":[39],"a":[40,145,234],"probe":[41],"compound":[42],"for":[43],"FGFR":[45,65,95,231],"inhibitor,":[46],"which":[47,162],"potently":[48],"inhibits":[49,53,152,156],"FGFR-1\u20133":[50],"significantly":[52,155,205],"FGFR-4.":[54,113],"The":[55,114],"purpose":[56],"of":[57,79,92,116,135,174,223],"study":[59],"is":[60,163,233],"to":[61,238],"determine":[62],"whether":[63],"targeting":[64],"from":[67],"all":[68,190],"four":[69],"FGFRs":[70],"will":[71,83],"have":[72],"activities":[75],"consistent":[76],"with":[77,220],"inhibition":[78,173,222],"tumor":[80,85,138,202],"progression":[81,86,139],"inhibit":[84],"vivo.":[88],"Experimental":[89],"Design:":[90],"Effects":[91],"AZ8010":[93,117,136,150],"on":[94,118,137],"invasion":[98,119,181],"were":[99],"analyzed":[100],"using":[101,144],"immortalized":[102],"normal":[103],"epithelial":[105],"(PNT1a)":[106],"cells":[107,184],"PNT1a":[109,183],"overexpressing":[110],"FGFR-1":[111,153,186],"or":[112],"effect":[115],"proliferation":[121,209],"was":[124,142,218],"also":[125],"evaluated":[126,143],"cell":[130,193,212],"lines.":[131],"Finally,":[132],"the":[133],"impact":[134],"vivo":[141,167,198],"VCaP":[146,201],"xenograft":[147],"model.":[148],"Results:":[149],"completely":[151,199],"FGFR-4":[157,188],"at":[159],"100":[160],"nmol/L,":[161],"achievable":[165],"concentration.":[168],"This":[169,217],"results":[170],"marked":[172,221],"extracellular":[175],"signal\u2013regulated":[176],"kinase":[177],"(ERK)":[178],"phosphorylation":[179,225],"expressing":[185],"lines":[194],"tested.":[195],"Treatment":[196],"inhibited":[200,206],"angiogenesis":[207],"increased":[211],"death":[213],"treated":[215,227],"tumors.":[216,228],"associated":[219],"ERK":[224],"Conclusions:":[229],"Targeting":[230],"promising":[235],"new":[236],"approach":[237],"treating":[239],"aggressive":[240],"cancer.":[242],"Clin":[243],"Cancer":[244],"Res;":[245],"18(14);":[246],"3880\u20138.":[247],"\u00a92012":[248],"AACR.":[249]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-04-05T00:00:00"}
