{"id":"https://openalex.org/W4361949665","doi":"https://doi.org/10.1158/1078-0432.c.6518838.v1","title":"Data from High WT1 Expression Is Associated with Very Poor Survival of Patients with Osteogenic Sarcoma Metastasis","display_name":"Data from High WT1 Expression Is Associated with Very Poor Survival of Patients with Osteogenic Sarcoma Metastasis","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361949665","doi":"https://doi.org/10.1158/1078-0432.c.6518838.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6518838.v1","doi":"https://doi.org/10.1158/1078-0432.c.6518838.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6518838.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6518838.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104110255","display_name":"Alok Srivastava","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alok Srivastava","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102812595","display_name":"Bruno Fuchs","orcid":"https://orcid.org/0000-0003-3766-2107","observed_orcids":["https://orcid.org/0000-0003-3766-2107"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Fuchs","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079579315","display_name":"Kunbo Zhang","orcid":"https://orcid.org/0000-0002-4826-6831","observed_orcids":["https://orcid.org/0000-0002-4826-6831","https://orcid.org/0009-0000-0769-7750"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kunbo Zhang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102630725","display_name":"Ming Ruan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ming Ruan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014726548","display_name":"Chandralekha Halder","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chandralekha Halder","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089564444","display_name":"Eric Mahlum","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric Mahlum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102310749","display_name":"Kristin Weber","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristin Weber","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077089290","display_name":"Mark E. Bolander","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark E. Bolander","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009037924","display_name":"Gobinda Sarkar","orcid":"https://orcid.org/0000-0002-7879-124X","observed_orcids":["https://orcid.org/0000-0002-7879-124X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gobinda Sarkar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10975","display_name":"Bone Tumor Diagnosis and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.9359999895095825},{"id":"https://openalex.org/keywords/osteosarcoma","display_name":"osteosarcoma","score":0.9350000023841858},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.7310000061988831},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7620000243186951},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5550000071525574},{"id":"https://openalex.org/keywords/metastatic-heterogeneity","display_name":"metastatic heterogeneity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/osteosarcoma-cell-lines","display_name":"osteosarcoma cell lines","score":0.781000018119812}],"concepts":[{"id":"https://openalex.org/C4224716","wikidata":"https://www.wikidata.org/wiki/Q10859258","display_name":"Immunostaining","level":3,"score":0.859974205493927},{"id":"https://openalex.org/C2778256501","wikidata":"https://www.wikidata.org/wiki/Q223911","display_name":"Sarcoma","level":2,"score":0.8285664319992065},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.6477364301681519},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.6085340976715088},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6053669452667236},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5863595604896545},{"id":"https://openalex.org/C2777760704","wikidata":"https://www.wikidata.org/wiki/Q549534","display_name":"Osteosarcoma","level":2,"score":0.5768721103668213},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5191613435745239},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.5175056457519531},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47079697251319885},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39999428391456604},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3605073094367981},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29568254947662354},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25536489486694336},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24891698360443115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06694358587265015}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6518838.v1","doi":"https://doi.org/10.1158/1078-0432.c.6518838.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6518838.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6518838.v1","doi":"https://doi.org/10.1158/1078-0432.c.6518838.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6518838.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2118873770","https://openalex.org/W2058384697","https://openalex.org/W2112519107","https://openalex.org/W2019066507","https://openalex.org/W1999069678","https://openalex.org/W2092701673","https://openalex.org/W1993267519","https://openalex.org/W4361943741","https://openalex.org/W7099582265","https://openalex.org/W1442459401"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Although":[2],"metastasis":[3],"is":[4],"the":[5,32,75,95,186],"primary":[6],"determinant":[7],"of":[8,11,31,41,74,94,102,117,147,160,166,168,183,185,194,206,216,227,240,271],"poor":[9,269],"survival":[10,27,39,108,193,215,270],"patients":[12,17,42,195,217,272],"with":[13,43,106,124,136,196,218,267,273],"osteogenic":[14,44,62,69,103,121,155,170,199,221,259,274],"sarcoma,":[15,70],"some":[16],"live":[18],"much":[19],"longer":[20],"than":[21],"others,":[22],"indicating":[23],"metastatic":[24,81,86,198,220],"heterogeneity":[25],"underlying":[26,38],"outcome.":[28,109],"The":[29],"purpose":[30],"investigation":[33],"was":[34,98,141,208,229],"to":[35,53,255,264],"identify":[36],"genes":[37,66],"outcome":[40],"sarcoma":[45,63,104,122,171,200,222,275],"metastasis.":[46,276],"Experimental":[47],"Design:":[48],"We":[49],"have":[50],"used":[51],"microarray":[52],"first":[54],"compare":[55],"mRNA":[56,119,140],"expression":[57,73,93,116],"between":[58,78],"normal":[59,125,144],"bone":[60,126,145],"and":[61,71,83,90,127,132,251],"specimens,":[64],"identified":[65],"overexpressed":[67],"in":[68,120,130,143,154,258],"compared":[72,123,135],"selected":[76,96],"gene":[77,97],"a":[79,244],"poorly":[80],"(SAOS)":[82],"two":[84],"highly":[85],"cell":[87,157],"lines":[88,158],"(LM8":[89],"143B).":[91],"Finally,":[92],"assessed":[99],"by":[100,149,178],"immunostaining":[101],"samples":[105],"known":[107],"Results:":[110],"Microarray":[111],"analysis":[112],"revealed":[113],"5.3-fold":[114],"more":[115],"WT1":[118,139,175,203,241,262],">2-fold":[128],"overexpression":[129],"143B":[131],"LM8":[133],"cells":[134],"SAOS.":[137],"Furthermore,":[138],"absent":[142],"(10":[146,226],"10)":[148],"reverse":[150],"transcription-PCR":[151],"but":[152,201],"present":[153],"sarcoma\u2013derived":[156],"(5":[159],"8).":[161],"One":[162],"hundred":[163],"percent":[164],"(42":[165],"42)":[167],"low-grade":[169],"specimens":[172,188],"expressed":[173,257],"no":[174],"as":[176],"determined":[177],"immunostaining;":[179],"however,":[180],"24%":[181],"(12":[182],"49)":[184],"high-grade":[187,197,219],"showed":[189],"intense":[190,224],"staining.":[191],"Mean":[192],"low":[202],"staining":[204,225],"(27":[205],"37)":[207,228],"96.5":[209],"\u00b1":[210,231],"129.3":[211],"months,":[212],"whereas":[213],"mean":[214],"having":[223],"18.3":[230],"12.3":[232],"months":[233],"(P":[234],">":[235],"0.0143).":[236],"All":[237],"splice":[238],"variants":[239],"mRNA,":[242],"including":[243],"hitherto":[245],"unknown":[246],"variant":[247],"(lacking":[248],"exons":[249],"4":[250],"5),":[252],"were":[253],"found":[254],"be":[256,265],"sarcoma.":[260],"Conclusion:":[261],"seems":[263],"associated":[266],"very":[268]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2023-04-05T00:00:00"}