{"id":"https://openalex.org/W4361948093","doi":"https://doi.org/10.1158/1535-7163.c.6531608","title":"Data from Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates","display_name":"Data from Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361948093","doi":"https://doi.org/10.1158/1535-7163.c.6531608"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6531608","doi":"https://doi.org/10.1158/1535-7163.c.6531608","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6531608","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1535-7163.c.6531608","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006246174","display_name":"Scott Eric Woodman","orcid":"https://orcid.org/0000-0002-1157-6991","observed_orcids":["https://orcid.org/0000-0002-1157-6991"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott E. Woodman","raw_affiliation_strings":["Melanoma Medical Oncology,","The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Medical Oncology,","institution_ids":[]},{"raw_affiliation_string":"The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004418792","display_name":"Jonathan C. Trent","orcid":"https://orcid.org/0000-0001-6169-5238","observed_orcids":["https://orcid.org/0000-0001-6169-5238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan C. Trent","raw_affiliation_strings":["Sarcoma Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004954310","display_name":"Katherine Stemke\u2010Hale","orcid":"https://orcid.org/0000-0002-1231-4192","observed_orcids":["https://orcid.org/0000-0002-1231-4192"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Stemke-Hale","raw_affiliation_strings":["Systems Biology,","The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology,","institution_ids":[]},{"raw_affiliation_string":"The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050445982","display_name":"Alexander J. Lazar","orcid":"https://orcid.org/0000-0002-6395-4499","observed_orcids":["https://orcid.org/0000-0002-6395-4499"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander J. Lazar","raw_affiliation_strings":["Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037395594","display_name":"Sabrina Pricl","orcid":"https://orcid.org/0000-0001-8380-4474","observed_orcids":["https://orcid.org/0000-0001-8380-4474"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Sabrina Pricl","raw_affiliation_strings":["Molecular Simulation Engineering Laboratory, DICAMP, University of Trieste, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Simulation Engineering Laboratory, DICAMP, University of Trieste, Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061158708","display_name":"Giovanni Maria Pavan","orcid":"https://orcid.org/0000-0002-3473-8471","observed_orcids":["https://orcid.org/0000-0002-3473-8471"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni M. Pavan","raw_affiliation_strings":["Molecular Simulation Engineering Laboratory, DICAMP, University of Trieste, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Simulation Engineering Laboratory, DICAMP, University of Trieste, Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003544522","display_name":"Maurizio Fermeglia","orcid":"https://orcid.org/0000-0001-8810-5082","observed_orcids":["https://orcid.org/0000-0001-8810-5082"]},"institutions":[{"id":"https://openalex.org/I142444530","display_name":"University of Trieste","ror":"https://ror.org/02n742c10","country_code":"IT","type":"education","lineage":["https://openalex.org/I142444530"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maurizio Fermeglia","raw_affiliation_strings":["Molecular Simulation Engineering Laboratory, DICAMP, University of Trieste, Trieste, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Simulation Engineering Laboratory, DICAMP, University of Trieste, Trieste, Italy","institution_ids":["https://openalex.org/I142444530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087379880","display_name":"Y.N. Vashisht Gopal","orcid":"https://orcid.org/0000-0002-3118-0011","observed_orcids":["https://orcid.org/0000-0002-3118-0011"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Y.N. Vashisht Gopal","raw_affiliation_strings":["The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100676802","display_name":"Dan Yang","orcid":"https://orcid.org/0000-0001-5959-1202","observed_orcids":["https://orcid.org/0000-0001-5959-1202"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dan Yang","raw_affiliation_strings":["Sarcoma Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarcoma Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008846063","display_name":"Donald A. Podoloff","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Donald A. Podoloff","raw_affiliation_strings":["Radiology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Radiology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087941785","display_name":"Doina S. Ivan","orcid":"https://orcid.org/0000-0002-4703-7009","observed_orcids":["https://orcid.org/0000-0002-4703-7009"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doina Ivan","raw_affiliation_strings":["Pathology, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015498468","display_name":"Kevin B. Kim","orcid":"https://orcid.org/0000-0003-0694-0530","observed_orcids":["https://orcid.org/0000-0003-0694-0530"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin B. Kim","raw_affiliation_strings":["Melanoma Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nicholas Papadopoulos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas Papadopoulos","raw_affiliation_strings":["Melanoma Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033798832","display_name":"Patrick Hwu","orcid":"https://orcid.org/0000-0002-8293-1313","observed_orcids":["https://orcid.org/0000-0002-8293-1313","https://orcid.org/0000-0003-0554-2856"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Hwu","raw_affiliation_strings":["Melanoma Medical Oncology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Medical Oncology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":["Systems Biology,","The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systems Biology,","institution_ids":[]},{"raw_affiliation_string":"The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048327749","display_name":"Michael A. Davies","orcid":"https://orcid.org/0000-0002-0977-0912","observed_orcids":["https://orcid.org/0000-0002-0977-0912"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael A. Davies","raw_affiliation_strings":["Melanoma Medical Oncology,","Systems Biology,","The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Melanoma Medical Oncology,","institution_ids":[]},{"raw_affiliation_string":"Systems Biology,","institution_ids":[]},{"raw_affiliation_string":"The Kleberg Center for Molecular Markers, M. D. Anderson Cancer Center, Houston, Texas; and","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048327749"],"corresponding_institution_ids":["https://openalex.org/I1343551460"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.9692000150680542,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":0.008999999612569809,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dasatinib","display_name":"dasatinib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9380000233650208},{"id":"https://openalex.org/keywords/kit-receptor-tyrosine-kinase","display_name":"KIT receptor tyrosine kinase","score":0.8939999938011169},{"id":"https://openalex.org/keywords/imatinib-resistance","display_name":"imatinib resistance","score":0.8309999704360962},{"id":"https://openalex.org/keywords/kit-inhibitors","display_name":"KIT inhibitors","score":0.7459999918937683},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.5889999866485596},{"id":"https://openalex.org/keywords/acral-lentiginous-melanoma","display_name":"acral lentiginous melanoma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/mucosal-melanoma","display_name":"mucosal melanoma","score":0.9459999799728394}],"concepts":[{"id":"https://openalex.org/C2779536868","wikidata":"https://www.wikidata.org/wiki/Q419940","display_name":"Dasatinib","level":4,"score":0.9190902709960938},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.7674139738082886},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.7080408334732056},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.5934698581695557},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5735384225845337},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.5727073550224304},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5140863060951233},{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.4563797116279602},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.43270471692085266},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.42949411273002625},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4246538281440735},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38578474521636963},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36479347944259644},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2838938236236572},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2715519070625305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19827920198440552},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.17292249202728271},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1059548556804657},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.07643947005271912},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07306867837905884},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.07276219129562378}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1535-7163.c.6531608","doi":"https://doi.org/10.1158/1535-7163.c.6531608","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6531608","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.c.6531608.v1","doi":"https://doi.org/10.1158/1535-7163.c.6531608.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6531608.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6531608","doi":"https://doi.org/10.1158/1535-7163.c.6531608","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1535-7163.c.6531608","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320308982","display_name":"American Society of Clinical Oncology","ror":"https://ror.org/04fy6j421"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W2013837038","https://openalex.org/W2019496774","https://openalex.org/W2019950585","https://openalex.org/W2031510245","https://openalex.org/W2036116069","https://openalex.org/W2059549347","https://openalex.org/W2078519247","https://openalex.org/W2079641245","https://openalex.org/W2084741194","https://openalex.org/W2103304755","https://openalex.org/W2111550284","https://openalex.org/W2118784542","https://openalex.org/W2126507367","https://openalex.org/W2131397638","https://openalex.org/W2132541027","https://openalex.org/W2136292975","https://openalex.org/W2152764077","https://openalex.org/W2156266404","https://openalex.org/W2159360580","https://openalex.org/W2163188200","https://openalex.org/W2168029948","https://openalex.org/W2313030973","https://openalex.org/W2323502629","https://openalex.org/W2409170623"],"related_works":["https://openalex.org/W2137020485","https://openalex.org/W2248463972","https://openalex.org/W1586064221","https://openalex.org/W2590617115","https://openalex.org/W2599316103","https://openalex.org/W2063346434","https://openalex.org/W2890554588","https://openalex.org/W3137568497","https://openalex.org/W2031510245","https://openalex.org/W4362568213"],"abstract_inverted_index":{"Abstract":[0],"Point":[1],"mutations":[2],"in":[3,14,41,71,110,188],"the":[4,25,36,49,53,79,82,104,114,135,174,183],"KIT":[5,39,68,76,111,137,186],"receptor":[6],"tyrosine":[7],"kinase":[8],"gene":[9],"have":[10,23],"recently":[11],"been":[12],"identified":[13,24],"mucosal,":[15],"acral":[16],"lentiginous,":[17],"and":[18,156,190,199],"chronically":[19],"sun-damaged":[20],"melanomas.":[21,201],"We":[22],"first":[26],"human":[27],"melanoma":[28,42,132],"cell":[29,50,56],"line":[30,57],"with":[31,74,134,141,148],"an":[32],"endogenous":[33],"L576P":[34,54,105,136],"mutation,":[35],"most":[37,184],"common":[38,185],"mutation":[40,106,138,187],"(\u223c30-40%).":[43],"In":[44],"vitro":[45],"testing":[46],"showed":[47],"that":[48,103,112],"viability":[51,80],"of":[52,81,158,178],"mutant":[55,83],"was":[58,85],"not":[59,123],"reduced":[60,86],"by":[61,87,162],"imatinib,":[62],"nilotinib,":[63],"or":[64],"sorafenib":[65],"small":[66],"molecule":[67],"inhibitors":[69],"effective":[70],"nonmelanoma":[72],"cells":[73,84,181],"other":[75],"mutations.":[77],"However,":[78],"dasatinib":[88,125,169,179],"at":[89],"concentrations":[90],"as":[91,93],"low":[92],"10":[94],"nM":[95],"(P":[96],"=":[97,119,127],"0.004).":[98],"Molecular":[99],"modeling":[100],"studies":[101],"found":[102],"induces":[107],"structural":[108],"changes":[109],"reduce":[113],"affinity":[115],"for":[116,124,195],"imatinib":[117],"(\u0394\u0394Gbind":[118,126],"\u22122.52":[120],"kcal/mol)":[121],"but":[122],"+0.32":[128],"kcal/mol).":[129],"Two":[130],"metastatic":[131],"patients":[133,151],"were":[139],"treated":[140,147],"dasatinib,":[142],"including":[143],"one":[144],"patient":[145],"previously":[146],"imatinib.":[149],"Both":[150],"had":[152],"marked":[153],"reduction":[154],"(>50%)":[155],"elimination":[157],"tumor":[159],"F18-fluorodeoxyglucose":[160],"(FDG)-avidity":[161],"positron":[163],"emission":[164],"tomography":[165],"(PET)":[166],"imaging":[167],"after":[168],"treatment.":[170],"These":[171],"data":[172],"support":[173],"selective":[175],"inhibitory":[176],"effect":[177],"against":[180],"harboring":[182],"melanoma,":[189],"thus":[191],"has":[192],"therapeutic":[193],"implications":[194],"acrallentiginous,":[196],"chronic":[197],"sun-damaged,":[198],"mucosal":[200],"[Mol":[202],"Cancer":[203],"Ther":[204],"2009;8(8):2079\u201385]":[205]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
