{"id":"https://openalex.org/W4361947673","doi":"https://doi.org/10.1158/1535-7163.c.6532038","title":"Data from Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid","display_name":"Data from Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361947673","doi":"https://doi.org/10.1158/1535-7163.c.6532038"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6532038","doi":"https://doi.org/10.1158/1535-7163.c.6532038","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6532038","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6532038","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083951666","display_name":"Sophie Domhan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE","US"],"is_corresponding":true,"raw_author_name":"Sophie Domhan","raw_affiliation_strings":["Center of Cancer Systems Biology, Department of Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine;","Department of Nephrology, University of Heidelberg Medical School, Heidelberg, Germany and","Department of Radiation Oncology, German Cancer Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cancer Systems Biology, Department of Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine;","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Nephrology, University of Heidelberg Medical School, Heidelberg, Germany and","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Radiation Oncology, German Cancer Research Center, and","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046259167","display_name":"Stefan Muschal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Muschal","raw_affiliation_strings":["Department of Radiation Oncology, German Cancer Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, German Cancer Research Center, and","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004854883","display_name":"Christian Schwager","orcid":"https://orcid.org/0000-0003-4945-0347","observed_orcids":["https://orcid.org/0000-0003-4945-0347"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Schwager","raw_affiliation_strings":["Department of Radiation Oncology, German Cancer Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, German Cancer Research Center, and","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012124988","display_name":"Christian P. Morath","orcid":"https://orcid.org/0000-0003-2218-7817","observed_orcids":["https://orcid.org/0000-0003-2218-7817"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Morath","raw_affiliation_strings":["Department of Nephrology, University of Heidelberg Medical School, Heidelberg, Germany and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, University of Heidelberg Medical School, Heidelberg, Germany and","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038649660","display_name":"Ute Wirkner","orcid":"https://orcid.org/0009-0006-3330-7633","observed_orcids":["https://orcid.org/0009-0006-3330-7633"]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ute Wirkner","raw_affiliation_strings":["Department of Radiation Oncology, German Cancer Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, German Cancer Research Center, and","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052404960","display_name":"Wilhelm J. Ansorge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wilhelm Ansorge","raw_affiliation_strings":["Department of Radiation Oncology, German Cancer Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, German Cancer Research Center, and","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049576970","display_name":"Christian Maercker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Maercker","raw_affiliation_strings":["Department of Radiation Oncology, German Cancer Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, German Cancer Research Center, and","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053398470","display_name":"Martin G. Zeier","orcid":"https://orcid.org/0000-0003-1700-959X","observed_orcids":["https://orcid.org/0000-0003-1700-959X"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Zeier","raw_affiliation_strings":["Department of Nephrology, University of Heidelberg Medical School, Heidelberg, Germany and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology, University of Heidelberg Medical School, Heidelberg, Germany and","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086658735","display_name":"Peter Ernst Huber","orcid":"https://orcid.org/0000-0002-4811-300X","observed_orcids":["https://orcid.org/0000-0002-4811-300X"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Peter E. Huber","raw_affiliation_strings":["Center of Cancer Systems Biology, Department of Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine;","Department of Radiation Oncology, German Cancer Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cancer Systems Biology, Department of Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine;","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Department of Radiation Oncology, German Cancer Research Center, and","institution_ids":["https://openalex.org/I17937529"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075116222","display_name":"Amir Abdollahi","orcid":"https://orcid.org/0000-0002-8016-5897","observed_orcids":["https://orcid.org/0000-0002-8016-5897"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Amir Abdollahi","raw_affiliation_strings":["Center of Cancer Systems Biology, Department of Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine;","Children's Hospital Boston, Vascular Biology Program & Harvard Medical School, Department of Surgery, Karp Family Research Laboratories, Boston, Massachusetts","Department of Radiation Oncology, German Cancer Research Center, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Cancer Systems Biology, Department of Medicine, Caritas St. Elizabeth's Medical Center, Tufts University School of Medicine;","institution_ids":["https://openalex.org/I121934306"]},{"raw_affiliation_string":"Children's Hospital Boston, Vascular Biology Program & Harvard Medical School, Department of Surgery, Karp Family Research Laboratories, Boston, Massachusetts","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Radiation Oncology, German Cancer Research Center, and","institution_ids":["https://openalex.org/I17937529"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5083951666"],"corresponding_institution_ids":["https://openalex.org/I121934306","https://openalex.org/I17937529","https://openalex.org/I223822909"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11469","display_name":"Lymphatic System and Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycophenolic-acid","display_name":"mycophenolic acid","score":1.0},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.9750000238418579},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7549999952316284},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.7820000052452087},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.777999997138977},{"id":"https://openalex.org/keywords/fibroblasts","display_name":"fibroblasts","score":0.9739999771118164},{"id":"https://openalex.org/keywords/myc-signaling","display_name":"MYC signaling","score":0.8080000281333923},{"id":"https://openalex.org/keywords/ndrg1","display_name":"NDRG1","score":0.9100000262260437},{"id":"https://openalex.org/keywords/hif1a","display_name":"HIF1A","score":0.9300000071525574},{"id":"https://openalex.org/keywords/hdac2","display_name":"HDAC2","score":0.8669999837875366},{"id":"https://openalex.org/keywords/cdc2","display_name":"cdc2","score":0.6690000295639038},{"id":"https://openalex.org/keywords/gsk3b","display_name":"GSK3B","score":0.9869999885559082},{"id":"https://openalex.org/keywords/prkacb","display_name":"PRKACB","score":0.9890000224113464},{"id":"https://openalex.org/keywords/microvessel-density","display_name":"microvessel density","score":0.7049999833106995},{"id":"https://openalex.org/keywords/pericyte-coverage","display_name":"pericyte coverage","score":0.9599999785423279},{"id":"https://openalex.org/keywords/tumor-fibrosis","display_name":"tumor fibrosis","score":0.5649999976158142},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.6859999895095825},{"id":"https://openalex.org/keywords/solid-organ-transplantation","display_name":"solid organ transplantation","score":0.6069999933242798},{"id":"https://openalex.org/keywords/cancer-risk","display_name":"cancer risk","score":0.5080000162124634}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.6160638928413391},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6064251661300659},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5763819813728333},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5217219591140747},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5204480290412903},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.45497632026672363},{"id":"https://openalex.org/C2909935303","wikidata":"https://www.wikidata.org/wiki/Q420553","display_name":"Mycophenolate","level":3,"score":0.4174254536628723},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.40288046002388},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3713436722755432},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3629039525985718},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.323735773563385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2992631793022156},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17553582787513733},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16285261511802673},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.11332938075065613},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6532038","doi":"https://doi.org/10.1158/1535-7163.c.6532038","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6532038","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6532038","doi":"https://doi.org/10.1158/1535-7163.c.6532038","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6532038","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1841849374","https://openalex.org/W1969369049","https://openalex.org/W1972567688","https://openalex.org/W1974228208","https://openalex.org/W1978349671","https://openalex.org/W1987373390","https://openalex.org/W1991054314","https://openalex.org/W1994453026","https://openalex.org/W2004463118","https://openalex.org/W2028641698","https://openalex.org/W2032220572","https://openalex.org/W2036048816","https://openalex.org/W2036195512","https://openalex.org/W2050898079","https://openalex.org/W2082496903","https://openalex.org/W2099102308","https://openalex.org/W2102421593","https://openalex.org/W2112302625","https://openalex.org/W2127524594","https://openalex.org/W2135374295","https://openalex.org/W2137373982","https://openalex.org/W2149099455","https://openalex.org/W2150758858","https://openalex.org/W2341007927"],"related_works":["https://openalex.org/W2117278013","https://openalex.org/W2042618164","https://openalex.org/W3087479836","https://openalex.org/W2032249564","https://openalex.org/W1982257612","https://openalex.org/W2350898771","https://openalex.org/W1540383800","https://openalex.org/W2104951985","https://openalex.org/W2102421593","https://openalex.org/W2050898079"],"abstract_inverted_index":{"Abstract":[0],"The":[1,204,220],"relative":[2],"risk":[3],"for":[4,169,245],"the":[5,21,28,32,92,133,137,182,226,246],"development":[6],"of":[7,31,35,91,142,185,206,223,229,251],"malignancies":[8],"following":[9],"solid":[10],"organ":[11],"transplantation":[12],"seems":[13],"to":[14,53,64],"be":[15],"decreased":[16],"in":[17,67,76,78,104,107,111,149,172,225],"patients":[18],"treated":[19,175],"with":[20,176],"immunosuppressive":[22],"agent":[23],"mycophenolic":[24],"acid":[25],"(MPA).":[26],"However,":[27,69],"molecular":[29,243],"mechanisms":[30],"antineoplastic":[33],"effects":[34,88,141,184,250],"MPA":[36,54,65,84,117,161,186,230],"are":[37,50],"not":[38],"completely":[39],"understood.":[40],"Here,":[41],"we":[42,114,144,179],"report":[43],"that":[44,58,83,116,181],"human":[45],"endothelial":[46,120,127,151,173],"cells":[47,61,154,174],"and":[48,98,122,126,139,152,157,194,201,217,248],"fibroblasts":[49],"highly":[51],"sensitive":[52],"treatment.":[55,162],"We":[56],"found":[57,180],"U87":[59,70],"glioblastoma":[60],"were":[62,101,187],"resistant":[63],"treatment":[66],"vitro.":[68],"tumor":[71,93],"growth":[72],"was":[73,210,231],"markedly":[74,102],"inhibited":[75,119],"vivo":[77],"BALB/c":[79],"nude":[80],"mice,":[81],"suggesting":[82],"exerted":[85],"its":[86],"antitumor":[87],"via":[89],"modulation":[90],"microenvironment.":[94],"Accordingly,":[95],"microvascular":[96],"density":[97],"pericyte":[99],"coverage":[100],"reduced":[103],"MPA-treated":[105],"tumors":[106],"vivo.":[108],"Using":[109],"functional":[110],"vitro":[112],"assays,":[113],"showed":[115],"potently":[118],"cell":[121,128],"fibroblast":[123,153],"proliferation,":[124],"invasion/migration,":[125],"tube":[129],"formation.":[130],"To":[131],"identify":[132],"genetic":[134],"participants":[135],"governing":[136],"antiangiogenic":[138,183,227,247],"antifibrotic":[140,249],"MPA,":[143,252],"performed":[145],"genome-wide":[146],"transcriptional":[147],"analysis":[148,164],"U87,":[150],"at":[155],"6":[156],"12":[158],"h":[159],"after":[160],"Network":[163],"revealed":[165],"a":[166,242],"critical":[167,221],"role":[168],"MYC":[170,193,224],"signaling":[171,228],"MPA.":[177],"Moreover,":[178],"organized":[188],"by":[189,212,234],"coordinated":[190],"communications":[191],"between":[192],"NDRG1,":[195],"YYI,":[196],"HIF1A,":[197],"HDAC2,":[198],"CDC2,":[199],"GSK3B,":[200],"PRKACB":[202],"signaling.":[203],"regulation":[205],"these":[207,239],"\u201chub":[208],"nodes\u201d":[209],"confirmed":[211],"real-time":[213],"quantitative":[214],"reverse":[215],"transcription-PCR":[216],"protein":[218],"analysis.":[219],"involvement":[222],"further":[232,255],"shown":[233],"gene":[235],"knockdown":[236],"experiments.":[237],"Together,":[238],"data":[240],"provide":[241],"basis":[244],"which":[253],"warrants":[254],"clinical":[256],"investigations.":[257],"[Mol":[258],"Cancer":[259],"Ther":[260],"2008;7(6):1656\u201368]":[261]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-04-05T00:00:00"}