{"id":"https://openalex.org/W4361947670","doi":"https://doi.org/10.1158/1535-7163.c.6532122","title":"Data from Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells","display_name":"Data from Algorithmic guided screening of drug combinations of arbitrary size for activity against cancer cells","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361947670","doi":"https://doi.org/10.1158/1535-7163.c.6532122"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.c.6532122","doi":"https://doi.org/10.1158/1535-7163.c.6532122","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6532122","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.c.6532122","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105167216","display_name":"Ralph Zinner","orcid":"https://orcid.org/0009-0009-6812-5540","observed_orcids":["https://orcid.org/0009-0009-6812-5540"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph G. Zinner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019704984","display_name":"Brittany L. Barrett","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brittany L. Barrett","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904805","display_name":"Elmira Popova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elmira Popova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043201304","display_name":"Paul Damien","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul Damien","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967152","display_name":"Andrei Y. Volgin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrei Y. Volgin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037658628","display_name":"Juri George Gelovani","orcid":"https://orcid.org/0000-0002-8413-6161","observed_orcids":["https://orcid.org/0000-0002-8413-6161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juri G. Gelovani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063003854","display_name":"Reuben Lotan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reuben Lotan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056267838","display_name":"Hai Thanh Tran","orcid":"https://orcid.org/0000-0003-4065-9355","observed_orcids":["https://orcid.org/0000-0003-4065-9355"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hai T. Tran","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045670524","display_name":"Claudio Pisano","orcid":"https://orcid.org/0000-0001-8624-2980","observed_orcids":["https://orcid.org/0000-0001-8624-2980"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudio Pisano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355195","display_name":"Mao Li","orcid":"https://orcid.org/0000-0001-8500-1165","observed_orcids":["https://orcid.org/0000-0001-8500-1165"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Li Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111144617","display_name":"Waun Ki Hong","orcid":"https://orcid.org/0009-0008-9329-5544","observed_orcids":["https://orcid.org/0009-0008-9329-5544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Waun K. Hong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069190968","display_name":"Scott Michael Lippman","orcid":"https://orcid.org/0000-0002-1643-4124","observed_orcids":["https://orcid.org/0000-0002-1643-4124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott M. Lippman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5021738971","display_name":"John Holmes Miller","orcid":"https://orcid.org/0000-0001-6383-1037","observed_orcids":["https://orcid.org/0000-0001-6383-1037"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John H. Miller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-combination-screening","display_name":"drug combination screening","score":0.9409999847412109},{"id":"https://openalex.org/keywords/macs","display_name":"MACS","score":0.4740000069141388},{"id":"https://openalex.org/keywords/fitness-function","display_name":"fitness function","score":0.5889999866485596},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6899999976158142},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8199999928474426},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8820000290870667},{"id":"https://openalex.org/keywords/fenretinide","display_name":"fenretinide","score":0.9110000133514404},{"id":"https://openalex.org/keywords/vorinostat","display_name":"vorinostat","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bortezomib","display_name":"bortezomib","score":1.0},{"id":"https://openalex.org/keywords/multidrug-therapy","display_name":"multidrug therapy","score":0.8169999718666077},{"id":"https://openalex.org/keywords/tumor-cell-inhibition","display_name":"cancer cell inhibition","score":0.44200000166893005},{"id":"https://openalex.org/keywords/wst-1-assay","display_name":"WST-1 assay","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.5654957890510559},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45812472701072693},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4399964213371277},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2457444965839386},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1486092209815979}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1535-7163.c.6532122","doi":"https://doi.org/10.1158/1535-7163.c.6532122","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6532122","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.c.6532122","doi":"https://doi.org/10.1158/1535-7163.c.6532122","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.c.6532122","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W2358668433","https://openalex.org/W2376932109","https://openalex.org/W2001405890","https://openalex.org/W2382290278","https://openalex.org/W2478288626","https://openalex.org/W2350741829","https://openalex.org/W2530322880","https://openalex.org/W1596801655"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"standard":[2],"treatment":[3],"for":[4,91],"most":[5],"advanced":[6],"cancers":[7],"is":[8],"multidrug":[9],"therapy.":[10],"Unfortunately,":[11],"combinations":[12,28,143,236],"in":[13,67,202,214,220,244,248],"the":[14,49,56,92,120,125,134,163,172,190,193,216],"clinic":[15],"often":[16],"do":[17],"not":[18,109],"perform":[19],"as":[20,96,240],"predicted.":[21],"Therefore,":[22],"to":[23,168,183],"complement":[24],"identifying":[25],"rational":[26],"drug":[27,40,53,235,246],"based":[29,118],"on":[30,44,119,133],"biological":[31],"assumptions,":[32],"we":[33,73,111,140],"hypothesized":[34],"that":[35,228],"a":[36,75,113,130,149,175,241,249],"functional":[37],"screen":[38],"of":[39,51,64,71,94,106,122,127,144,174,178,192,253],"combinations,":[41],"without":[42],"limits":[43],"combination":[45,245],"sizes,":[46],"will":[47],"aid":[48],"identification":[50],"effective":[52],"cocktails.":[54],"Given":[55],"myriad":[57],"possible":[58],"cocktails":[59,179],"and":[60,124,159],"inspired":[61],"by":[62,89,98,187,231],"examples":[63],"search":[65,78],"algorithms":[66,87],"diverse":[68],"fields":[69],"outside":[70],"medicine,":[72],"developed":[74,112],"novel,":[76],"efficient":[77],"strategy":[79],"called":[80],"Medicinal":[81],"Algorithmic":[82],"Combinatorial":[83],"Screen":[84],"(MACS).":[85],"Such":[86],"work":[88],"enriching":[90],"fitness":[93,116],"cocktails,":[95],"defined":[97],"specific":[99],"attributes":[100],"through":[101,138],"successive":[102],"generations.":[103,154],"Because":[104],"assessment":[105],"synergy":[107],"was":[108,162,200,211,223],"feasible,":[110],"novel":[114],"alternative":[115],"function":[117],"level":[121],"inhibition":[123],"number":[126,252],"drugs.":[128],"Using":[129],"WST-1":[131],"assay":[132],"A549":[135],"cell":[136,207,218],"line,":[137],"MACS,":[139,232],"screened":[141],"72":[142],"arbitrary":[145],"size":[146],"formed":[147],"from":[148],"19-drug":[150],"pool":[151],"across":[152],"four":[153],"Fenretinide,":[155],"suberoylanilide":[156],"hydroxamic":[157],"acid,":[158],"bortezomib":[160],"(FSB)":[161],"fittest.":[164],"FSB":[165,199],"performed":[166],"up":[167],"4.18":[169],"SD":[170],"above":[171],"mean":[173],"random":[176],"set":[177],"or":[180],"\u201ctoo":[181],"well\u201d":[182],"have":[184],"been":[185],"found":[186],"chance,":[188],"supporting":[189],"utility":[191],"MACS":[194],"strategy.":[195],"Validation":[196],"studies":[197],"showed":[198],"inhibitory":[201],"all":[203],"7":[204],"other":[205],"NSCLC":[206],"lines":[208],"tested.":[209],"It":[210],"also":[212],"synergistic":[213],"A549,":[215],"one":[217],"line":[219],"which":[221],"this":[222],"evaluated.":[224],"These":[225],"results":[226],"suggest":[227],"when":[229],"guided":[230],"screening":[233],"larger":[234],"may":[237],"be":[238],"feasible":[239],"first":[242],"step":[243],"discovery":[247],"relatively":[250],"small":[251],"experiments.":[254],"[Mol":[255],"Cancer":[256],"Ther":[257],"2009;8(3):521\u201332]":[258]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}