{"id":"https://openalex.org/W4361947293","doi":"https://doi.org/10.1158/1078-0432.c.6529709","title":"Data from Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival","display_name":"Data from Surfactant Expression Defines an Inflamed Subtype of Lung Adenocarcinoma Brain Metastases that Correlates with Prolonged Survival","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361947293","doi":"https://doi.org/10.1158/1078-0432.c.6529709"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6529709","doi":"https://doi.org/10.1158/1078-0432.c.6529709","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6529709","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6529709","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045140301","display_name":"Kolja Pocha","orcid":"https://orcid.org/0009-0002-7386-1357","observed_orcids":["https://orcid.org/0009-0002-7386-1357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kolja Pocha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069790818","display_name":"Andreas M\u00f6ck","orcid":"https://orcid.org/0000-0002-3332-9166","observed_orcids":["https://orcid.org/0000-0002-3332-9166"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Mock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034274607","display_name":"Carmen Rapp","orcid":"https://orcid.org/0009-0001-5935-5127","observed_orcids":["https://orcid.org/0009-0001-5935-5127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Rapp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033389304","display_name":"Steffen Dettling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steffen Dettling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014216255","display_name":"Rolf Warta","orcid":"https://orcid.org/0000-0003-2821-4361","observed_orcids":["https://orcid.org/0000-0003-2821-4361"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rolf Warta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071462400","display_name":"Christoph Geisenberger","orcid":"https://orcid.org/0000-0002-5846-7127","observed_orcids":["https://orcid.org/0000-0002-5846-7127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christoph Geisenberger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080916428","display_name":"Christine Jungk","orcid":"https://orcid.org/0009-0004-7911-0268","observed_orcids":["https://orcid.org/0009-0004-7911-0268"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Jungk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005841369","display_name":"Leila R. Martins","orcid":"https://orcid.org/0000-0002-5887-4734","observed_orcids":["https://orcid.org/0000-0002-5887-4734"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leila R. Martins","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5887-4734","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039930487","display_name":"Niels Grabe","orcid":"https://orcid.org/0000-0003-1732-3706","observed_orcids":["https://orcid.org/0000-0003-1732-3706"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Niels Grabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056148870","display_name":"David Reu\u00df","orcid":"https://orcid.org/0000-0002-4573-6033","observed_orcids":["https://orcid.org/0000-0002-4573-6033"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Reuss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Juergen Debus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juergen Debus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052657395","display_name":"Andreas von Deimling","orcid":"https://orcid.org/0000-0002-5863-540X","observed_orcids":["https://orcid.org/0000-0002-5863-540X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas von Deimling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075116222","display_name":"Amir Abdollahi","orcid":"https://orcid.org/0000-0002-8016-5897","observed_orcids":["https://orcid.org/0000-0002-8016-5897"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amir Abdollahi","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-8016-5897","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014073957","display_name":"Andreas Wilhelm Unterberg","orcid":"https://orcid.org/0000-0003-3742-3288","observed_orcids":["https://orcid.org/0000-0003-3742-3288"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andreas Unterberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5025477516","display_name":"Christel C. Herold\u2010Mende","orcid":"https://orcid.org/0000-0002-1915-745X","observed_orcids":["https://orcid.org/0000-0002-1915-745X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christel C. Herold-Mende","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.5557000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.38350000977516174,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9200000166893005},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9879999756813049},{"id":"https://openalex.org/keywords/surfactant-metabolism","display_name":"surfactant metabolism","score":0.7689999938011169},{"id":"https://openalex.org/keywords/sftpa1","display_name":"SFTPA1","score":0.9419999718666077},{"id":"https://openalex.org/keywords/surfactant-protein-b","display_name":"surfactant protein B","score":1.0},{"id":"https://openalex.org/keywords/tumor-infiltrating-lymphocytes","display_name":"tumor-infiltrating lymphocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tumor-infiltrating-macrophages","display_name":"tumor-infiltrating macrophages","score":0.7149999737739563},{"id":"https://openalex.org/keywords/alveolar-type-ii-cells","display_name":"alveolar type II cells","score":0.7850000262260437},{"id":"https://openalex.org/keywords/tumor-microenvironment-inflammation","display_name":"tumor microenvironment inflammation","score":0.7409999966621399},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.875},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.6349999904632568},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.4099999964237213},{"id":"https://openalex.org/keywords/single-cell-rna-sequencing","display_name":"single-cell RNA sequencing","score":0.5740000009536743},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.7929236888885498},{"id":"https://openalex.org/C2778164965","wikidata":"https://www.wikidata.org/wiki/Q1620196","display_name":"Brain metastasis","level":4,"score":0.6469347476959229},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.6104087829589844},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.551837682723999},{"id":"https://openalex.org/C2778326572","wikidata":"https://www.wikidata.org/wiki/Q7852668","display_name":"Tumor-infiltrating lymphocytes","level":4,"score":0.5446982979774475},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.46318602561950684},{"id":"https://openalex.org/C2779130545","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain tumor","level":2,"score":0.4530855417251587},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4453731179237366},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44456642866134644},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.44019803404808044},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.43677806854248047},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43502119183540344},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4214099645614624},{"id":"https://openalex.org/C2779727006","wikidata":"https://www.wikidata.org/wiki/Q426188","display_name":"FOXP3","level":3,"score":0.41170990467071533},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3762114942073822},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2530650198459625},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21986821293830872},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21275576949119568}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6529709","doi":"https://doi.org/10.1158/1078-0432.c.6529709","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6529709","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6529709","doi":"https://doi.org/10.1158/1078-0432.c.6529709","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6529709","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3000221494","https://openalex.org/W4361889020","https://openalex.org/W4361889159","https://openalex.org/W4361937658","https://openalex.org/W4361889039","https://openalex.org/W4361937775","https://openalex.org/W4361937776","https://openalex.org/W4361937688","https://openalex.org/W4414786589","https://openalex.org/W4416141069"],"abstract_inverted_index":{"AbstractPurpose:":[0],"To":[1],"provide":[2],"a":[3,53,71,194,205,210,249,253],"better":[4],"understanding":[5],"of":[6,46,58,61,73,129,170,185,213,220,232,241],"the":[7,10,59],"interplay":[8],"between":[9,197],"immune":[11,186],"system":[12],"and":[13,50,98,136,200,226,252],"brain":[14,36,64,80,122,151,165,235],"metastases":[15,37,65,81,166,236],"to":[16,84,246,261],"advance":[17],"therapeutic":[18],"options":[19],"for":[20],"this":[21],"life-threatening":[22],"disease.":[23],"Experimental":[24],"Design:":[25],"Tumor-infiltrating":[26],"lymphocytes":[27],"(TIL)":[28],"were":[29,66,82],"quantified":[30],"by":[31,68,238],"semiautomated":[32],"whole-slide":[33],"analysis":[34],"in":[35,63,70,77,117,150,155,189,243],"from":[38,175],"81":[39],"lung":[40,78,88,120,157,191,233],"adenocarcinomas.":[41],"Multi-color":[42],"staining":[43],"enabled":[44],"phenotyping":[45],"TILs":[47,62,242],"(CD3,":[48],"CD8,":[49],"FOXP3)":[51],"on":[52],"single-cell":[54,99],"resolution.":[55],"Molecular":[56],"determinants":[57],"extent":[60],"analyzed":[67],"transcriptomics":[69,125],"subset":[72],"63":[74],"patients.":[75],"Findings":[76],"adenocarcinoma":[79,89,121,192,234],"related":[83],"published":[85],"multi-omic":[86],"primary":[87,156,190],"The":[90,218],"Cancer":[91],"Genome":[92],"Atlas":[93],"data":[94,102,162],"(n":[95,103],"=":[96,104],"230)":[97],"RNA-sequencing":[100],"(scRNA-seq)":[101],"52,698).":[105],"Results:":[106],"TIL":[107,142],"numbers":[108],"within":[109],"tumor":[110,176,247,254],"islands":[111],"was":[112,138,146],"an":[113,214,229],"independent":[114],"prognostic":[115,149],"marker":[116],"patients":[118],"with":[119,141,160,167,204],"metastases.":[123],"Comparative":[124],"revealed":[126,163],"that":[127,164],"expression":[128,145,169,208,219],"three":[130],"surfactant":[131,171,201,207,221],"metabolism-related":[132,222],"genes":[133,172,223],"(SFTPA1,":[134,224],"SFTPB,":[135,225],"NAPSA)":[137,227],"closely":[139],"associated":[140],"numbers.":[143],"Their":[144],"not":[147],"only":[148],"metastasis":[152],"but":[153],"also":[154],"adenocarcinoma.":[158],"Correlation":[159],"scRNA-seq":[161],"high":[168,206,239],"might":[173,257],"originate":[174],"cells":[177],"resembling":[178],"alveolar":[179],"type":[180],"2":[181],"cells.":[182],"Methylome-based":[183],"estimation":[184],"cell":[187],"fractions":[188],"confirmed":[193],"positive":[195],"association":[196],"lymphocyte":[198],"infiltration":[199],"expression.":[202],"Tumors":[203],"displayed":[209],"transcriptomic":[211],"profile":[212],"inflammatory":[215],"microenvironment.":[216],"Conclusions:":[217],"defines":[228],"inflamed":[230],"subtype":[231],"characterized":[237],"abundance":[240],"close":[244],"vicinity":[245],"cells,":[248],"prolonged":[250],"survival,":[251],"microenvironment":[255],"which":[256],"be":[258],"more":[259],"accessible":[260],"immunotherapeutic":[262],"approaches.":[263]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-05T00:00:00"}