{"id":"https://openalex.org/W4361947243","doi":"https://doi.org/10.1158/1078-0432.c.6530256","title":"Data from Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?","display_name":"Data from Delving into Early-onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361947243","doi":"https://doi.org/10.1158/1078-0432.c.6530256"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6530256","doi":"https://doi.org/10.1158/1078-0432.c.6530256","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6530256","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6530256","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008869204","display_name":"Erica S. Tsang","orcid":"https://orcid.org/0000-0003-2317-2721","observed_orcids":["https://orcid.org/0000-0003-2317-2721"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erica S. Tsang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081831776","display_name":"James Thomas Topham","orcid":"https://orcid.org/0009-0001-6601-8807","observed_orcids":["https://orcid.org/0009-0001-6601-8807"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James T. Topham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036473360","display_name":"Joanna M. Karasinska","orcid":"https://orcid.org/0000-0001-6861-4189","observed_orcids":["https://orcid.org/0000-0001-6861-4189"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna M. Karasinska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073611908","display_name":"Michael K.C. Lee","orcid":"https://orcid.org/0000-0001-8075-3608","observed_orcids":["https://orcid.org/0000-0001-8075-3608"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael K.C. Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8075-3608","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091086534","display_name":"Laura Williamson","orcid":"https://orcid.org/0000-0001-6461-2346","observed_orcids":["https://orcid.org/0000-0001-6461-2346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura M. Williamson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074901251","display_name":"Shehara Ramyalini Mendis","orcid":"https://orcid.org/0000-0001-9175-6329","observed_orcids":["https://orcid.org/0000-0001-9175-6329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shehara Mendis","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-9175-6329","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088325035","display_name":"Robert Edward Denroche","orcid":"https://orcid.org/0000-0003-2197-7083","observed_orcids":["https://orcid.org/0000-0003-2197-7083"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert E. Denroche","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2197-7083","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091747658","display_name":"Gun Ho Jang","orcid":"https://orcid.org/0000-0001-8169-7011","observed_orcids":["https://orcid.org/0000-0001-8169-7011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gun Ho Jang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085580353","display_name":"Steve E. Kalloger","orcid":"https://orcid.org/0000-0003-1332-7881","observed_orcids":["https://orcid.org/0000-0003-1332-7881"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steve E. Kalloger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001333381","display_name":"Richard A. Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard A. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052194762","display_name":"Andrew J. J. Mungall","orcid":"https://orcid.org/0000-0002-0905-2742","observed_orcids":["https://orcid.org/0000-0002-0905-2742"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew J. Mungall","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-0905-2742","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067532125","display_name":"Oliver F. Bathe","orcid":"https://orcid.org/0000-0003-2305-4602","observed_orcids":["https://orcid.org/0000-0003-2305-4602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver F. Bathe","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2305-4602","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023283384","display_name":"Patricia A. Tang","orcid":"https://orcid.org/0000-0003-1497-8539","observed_orcids":["https://orcid.org/0000-0003-1497-8539"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia A. Tang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1497-8539","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061402791","display_name":"Faiyaz Notta","orcid":"https://orcid.org/0000-0002-5748-3985","observed_orcids":["https://orcid.org/0000-0002-5748-3985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Faiyaz Notta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080925994","display_name":"Julie M. Wilson","orcid":"https://orcid.org/0000-0003-2510-962X","observed_orcids":["https://orcid.org/0000-0003-2510-962X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie M. Wilson","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2510-962X","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088331751","display_name":"Janessa J. Laskin","orcid":"https://orcid.org/0000-0002-0161-9329","observed_orcids":["https://orcid.org/0000-0002-0161-9329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janessa Laskin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017021482","display_name":"Grainne Mary O'Kane","orcid":"https://orcid.org/0000-0002-8690-403X","observed_orcids":["https://orcid.org/0000-0002-8690-403X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grainne M. O'Kane","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068644454","display_name":"Jennifer Jane Knox","orcid":"https://orcid.org/0000-0003-3474-6647","observed_orcids":["https://orcid.org/0000-0003-3474-6647"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer J. Knox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014239053","display_name":"Rachel Anne Goodwin","orcid":"https://orcid.org/0000-0002-0250-8479","observed_orcids":["https://orcid.org/0000-0002-0250-8479"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel A. Goodwin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066894564","display_name":"Jonathan M. Loree","orcid":"https://orcid.org/0000-0001-8189-2132","observed_orcids":["https://orcid.org/0000-0001-8189-2132"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan M. Loree","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8189-2132","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100728059","display_name":"Steven J.M. Jones","orcid":"https://orcid.org/0000-0003-3394-2208","observed_orcids":["https://orcid.org/0000-0003-3394-2208","https://orcid.org/0000-0002-3927-3562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven J.M. Jones","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3394-2208","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070061359","display_name":"Marco A. Marra","orcid":"https://orcid.org/0000-0001-7146-7175","observed_orcids":["https://orcid.org/0000-0001-7146-7175"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marco A. Marra","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7146-7175","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110966875","display_name":"Steve Gallinger","orcid":"https://orcid.org/0000-0002-6998-9414","observed_orcids":["https://orcid.org/0000-0002-6998-9414","https://orcid.org/0000-0001-5004-8393"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven Gallinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104256891","display_name":"David F. Schaeffer","orcid":"https://orcid.org/0000-0002-7341-1308","observed_orcids":["https://orcid.org/0000-0002-7341-1308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David F. Schaeffer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5001731680","display_name":"Daniel John Renouf","orcid":"https://orcid.org/0000-0002-7597-6089","observed_orcids":["https://orcid.org/0000-0002-7597-6089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel J. Renouf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cdkn2a","display_name":"CDKN2A","score":0.8399999737739563},{"id":"https://openalex.org/keywords/foxc2","display_name":"FOXC2","score":0.9039999842643738},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.996999979019165},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.8069999814033508},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2780265364","wikidata":"https://www.wikidata.org/wiki/Q5009957","display_name":"CDKN2A","level":3,"score":0.6905356645584106},{"id":"https://openalex.org/C119054055","wikidata":"https://www.wikidata.org/wiki/Q1576681","display_name":"Indel","level":5,"score":0.5778008699417114},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5286246538162231},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4633375406265259},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36434677243232727},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3419414162635803},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29083529114723206},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28775981068611145},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.28371742367744446},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2488570511341095},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.23665454983711243},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08875685930252075}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6530256","doi":"https://doi.org/10.1158/1078-0432.c.6530256","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6530256","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6530256","doi":"https://doi.org/10.1158/1078-0432.c.6530256","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6530256","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3087061153","https://openalex.org/W3095150946","https://openalex.org/W2995905315","https://openalex.org/W2910527546","https://openalex.org/W4390192655","https://openalex.org/W7162695633","https://openalex.org/W2591466290","https://openalex.org/W4401605589","https://openalex.org/W7128663404","https://openalex.org/W4408900002"],"abstract_inverted_index":{"AbstractPurpose:":[0],"With":[1],"the":[2,158,258],"rising":[3],"incidence":[4],"of":[5,37,63,72,82,91,121,140,160,170,228,236,244,253,269],"early-onset":[6,14],"pancreatic":[7,15],"cancer":[8],"(EOPC),":[9],"molecular":[10,267],"characteristics":[11,268],"that":[12],"distinguish":[13],"ductal":[16],"adenocarcinoma":[17],"(PDAC)":[18],"tumors":[19,116,166,187],"from":[20,43,232],"those":[21],"arising":[22],"at":[23],"a":[24,154,233,241],"later":[25,168],"age":[26],"are":[27],"not":[28],"well":[29,101],"understood.":[30],"Experimental":[31],"Design:":[32],"We":[33],"performed":[34],"bioinformatic":[35],"analysis":[36,227],"genomic":[38],"and":[39,50,79,110,132,209,219,262],"transcriptomic":[40],"data":[41,230],"generated":[42,231],"269":[44],"advanced":[45],"(metastatic":[46],"or":[47],"locally":[48],"advanced)":[49],"277":[51],"resectable":[52],"PDAC":[53,197,237],"tumor":[54],"samples.":[55],"Patient":[56],"samples":[57,198,239],"were":[58,106,133,199],"stratified":[59],"into":[60],"EOPC":[61,109,115,186,249],"(age":[62,71,81],"onset":[64,73,83,171],"\u226455":[65],"years;":[66,75,85],"n":[67,76,86],"=":[68,77,87,130,173,189,213,217,222],"117),":[69],"intermediate":[70],"55\u201370":[74],"264),":[78],"average":[80],"\u226570":[84],"165)":[88],"groups.":[89,113],"Frequency":[90],"somatic":[92,122],"mutations":[93],"affecting":[94],"genes":[95],"commonly":[96],"implicated":[97],"in":[98,127,185,196,248,255],"PDAC,":[99],"as":[100,102,146],"gene":[103,202],"expression":[104,252],"patterns,":[105],"compared":[107],"between":[108,260],"all":[111],"other":[112],"Results:":[114],"showed":[117],"significantly":[118,183,192],"lower":[119],"frequency":[120],"single-nucleotide":[123],"variant":[124],"(SNV)/insertions/deletions":[125],"(indel)":[126],"CDKN2A":[128,141,246],"(P":[129,172,188,212,216,221],"0.0017),":[131],"more":[134,163],"likely":[135],"to":[136,148,205],"achieve":[137],"biallelic":[138,245],"mutation":[139,247],"through":[142],"homozygous":[143],"copy":[144,150],"loss":[145,151],"opposed":[147],"heterozygous":[149],"coupled":[152],"with":[153,167,194,257],"loss-of-function":[155],"SNV/indel":[156],"mutation,":[157],"latter":[159],"which":[161],"was":[162,182],"common":[164],"for":[165,201],"ages":[169],"1.5e-4).":[174],"Transcription":[175],"factor":[176],"forkhead":[177],"box":[178],"protein":[179],"C2":[180],"(FOXC2)":[181],"upregulated":[184],"0.032).":[190],"Genes":[191],"correlated":[193],"FOXC2":[195,254,261],"enriched":[200],"sets":[203],"related":[204,272],"epithelial-to-mesenchymal":[206],"transition":[207],"(EMT)":[208],"included":[210],"VIM":[211],"1.8e-8),":[214],"CDH11":[215],"6.5e-5),":[218],"CDH2":[220],"2.4e-2).":[223],"Conclusions:":[224],"Our":[225],"comprehensive":[226],"sequencing":[229],"large":[234],"cohort":[235],"patient":[238],"highlights":[240],"distinctive":[242],"pattern":[243],"tumors.":[250],"Increased":[251],"EOPC,":[256],"correlation":[259],"EMT":[263],"pathways,":[264],"represents":[265],"novel":[266],"EOPC.":[270],"See":[271],"commentary":[273],"by":[274],"Lou,":[275],"p.":[276],"8":[277]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2023-04-05T00:00:00"}
