{"id":"https://openalex.org/W4361946642","doi":"https://doi.org/10.1158/1078-0432.c.6528416","title":"Data from Phase I Trial of an ICAM-1-Targeted Immunotherapeutic-Coxsackievirus A21 (CVA21) as an Oncolytic Agent Against Non Muscle-Invasive Bladder Cancer","display_name":"Data from Phase I Trial of an ICAM-1-Targeted Immunotherapeutic-Coxsackievirus A21 (CVA21) as an Oncolytic Agent Against Non Muscle-Invasive Bladder Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361946642","doi":"https://doi.org/10.1158/1078-0432.c.6528416"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6528416","doi":"https://doi.org/10.1158/1078-0432.c.6528416","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6528416","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6528416","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003039959","display_name":"Nicola E. Annels","orcid":"https://orcid.org/0000-0002-6795-5616","observed_orcids":["https://orcid.org/0000-0002-6795-5616"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola E. Annels","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037956238","display_name":"David Mansfield","orcid":"https://orcid.org/0000-0003-4165-015X","observed_orcids":["https://orcid.org/0000-0003-4165-015X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Mansfield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045819","display_name":"Mehreen Arif","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehreen Arif","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058602789","display_name":"Carmen Ballesteros\u2010Merino","orcid":"https://orcid.org/0000-0002-5073-7188","observed_orcids":["https://orcid.org/0000-0002-5073-7188"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Ballesteros-Merino","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5073-7188","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042492746","display_name":"Guy R. Simpson","orcid":"https://orcid.org/0000-0003-0447-5436","observed_orcids":["https://orcid.org/0000-0003-0447-5436"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guy R. Simpson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110625030","display_name":"Mick Denyer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mick Denyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111279479","display_name":"S.S. Sandhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sarbjinder S. Sandhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069116024","display_name":"Alan A. Melcher","orcid":"https://orcid.org/0000-0002-2042-3380","observed_orcids":["https://orcid.org/0000-0002-2042-3380"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan A. Melcher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072284989","display_name":"Kevin Joseph Harrington","orcid":"https://orcid.org/0000-0002-6014-348X","observed_orcids":["https://orcid.org/0000-0002-6014-348X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kevin J. Harrington","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Bronwyn Davies","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bronwyn Davies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016932799","display_name":"Gough G. Au","orcid":"https://orcid.org/0000-0001-6923-8875","observed_orcids":["https://orcid.org/0000-0001-6923-8875"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gough Au","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036913386","display_name":"Mark Grose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Grose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014830981","display_name":"Izhar Bagwan","orcid":"https://orcid.org/0000-0003-4016-4766","observed_orcids":["https://orcid.org/0000-0003-4016-4766"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Izhar Bagwan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067266240","display_name":"Bernard A. Fox","orcid":"https://orcid.org/0000-0002-4452-5947","observed_orcids":["https://orcid.org/0000-0002-4452-5947"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernard Fox","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070554485","display_name":"Richard G. Vile","orcid":"https://orcid.org/0000-0003-2192-9372","observed_orcids":["https://orcid.org/0000-0003-2192-9372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Vile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081888569","display_name":"Hugh A. Mostafid","orcid":"https://orcid.org/0000-0002-5095-2929","observed_orcids":["https://orcid.org/0000-0002-5095-2929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hugh Mostafid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113715397","display_name":"Darren R. Shafren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darren Shafren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5023174546","display_name":"Hardev S. Pandha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hardev S. Pandha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.7759000062942505,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.2061000019311905,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coxsackievirus-a21","display_name":"coxsackievirus A21","score":0.9520000219345093},{"id":"https://openalex.org/keywords/oncolytic-virotherapy","display_name":"oncolytic virotherapy","score":0.8970000147819519},{"id":"https://openalex.org/keywords/non-muscle-invasive-bladder-cancer","display_name":"non-muscle-invasive bladder cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/intravesical-therapy","display_name":"intravesical therapy","score":0.796999990940094},{"id":"https://openalex.org/keywords/tumor-inflammation","display_name":"tumor inflammation","score":0.5799999833106995},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7129999995231628},{"id":"https://openalex.org/keywords/pd-l1","display_name":"PD-L1","score":0.8690000176429749},{"id":"https://openalex.org/keywords/lag-3","display_name":"LAG-3","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rig-i","display_name":"RIG-I","score":0.9340000152587891},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8339999914169312},{"id":"https://openalex.org/keywords/antitumor-immunity","display_name":"antitumor immunity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.5789999961853027},{"id":"https://openalex.org/keywords/maximum-tolerated-dose","display_name":"maximum tolerated dose","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.7951593399047852},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.7870105504989624},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7452415823936462},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5099080801010132},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5023889541625977},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.4989159107208252},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4100683629512787},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38495439291000366},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3712279200553894},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32848864793777466},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32360029220581055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6528416","doi":"https://doi.org/10.1158/1078-0432.c.6528416","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6528416","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6528416","doi":"https://doi.org/10.1158/1078-0432.c.6528416","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6528416","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2954843732","https://openalex.org/W2588772539","https://openalex.org/W2789761490","https://openalex.org/W4383302346","https://openalex.org/W2176592687","https://openalex.org/W7162565033","https://openalex.org/W2971798409","https://openalex.org/W2935706507","https://openalex.org/W2563010432","https://openalex.org/W2048095498"],"abstract_inverted_index":{"AbstractPurpose:":[0],"The":[1,47,82,215],"CANON":[2],"[CAVATAK":[3],"in":[4,30,57,111,136,145,152,205,235],"NON\u2013muscle-invasive":[5],"bladder":[6,22,40,79,194],"cancer":[7,80,195],"(NMIBC)]":[8],"study":[9],"evaluated":[10],"a":[11,17,66,140,251],"novel":[12,18,252],"ICAM-1\u2013targeted":[13],"immunotherapeutic-coxsackievirus":[14],"A21":[15],"as":[16,182,184,250],"oncolytic":[19],"agent":[20],"against":[21],"cancer.":[23],"Patients":[24],"and":[25,90,108,126,139,177,179,226],"Methods:":[26],"Fifteen":[27],"patients":[28,50,62],"enrolled":[29],"this":[31],"\u201cwindow":[32],"of":[33,54,69,76,99,103,117,123,134,143,187,219,222],"opportunity\u201d":[34],"phase":[35],"I":[36],"study,":[37],"exposing":[38],"primary":[39,83],"cancers":[41],"to":[42,45,73,86],"CAVATAK":[43,64,118,135,157,245],"prior":[44],"surgery.":[46],"first":[48],"9":[49],"received":[51,63],"intravesical":[52],"administration":[53],"monotherapy":[55],"CAVATAK;":[56],"the":[58,185,188,232,239],"second":[59],"stage,":[60],"6":[61],"with":[65,154,193,231],"subtherapeutic":[67],"dose":[68,93],"mitomycin":[70,155],"C,":[71,156],"known":[72],"enhance":[74],"expression":[75],"ICAM-1":[77],"on":[78],"cells.":[81],"endpoint":[84],"was":[85,119],"determine":[87],"patient":[88],"safety":[89,217],"maximum":[91],"tolerated":[92],"(MTD).":[94],"Secondary":[95],"endpoints":[96],"were":[97,203],"evidence":[98],"viral":[100,223],"replication,":[101,225],"induction":[102,122,186],"inflammatory":[104,160],"cytokines,":[105],"antitumor":[106],"activity,":[107],"viral-induced":[109],"changes":[110,161],"resected":[112],"tissue.":[113],"Results:":[114],"Clinical":[115],"activity":[116],"demonstrated":[120],"by":[121,166],"tumor":[124,144,227,240],"inflammation":[125],"hemorrhage":[127],"following":[128],"either":[129,209],"single":[130],"or":[131,151,211],"multiple":[132,137],"administrations":[133],"patients,":[138],"complete":[141],"resolution":[142],"1":[146],"patient.":[147],"Whether":[148],"used":[149],"alone":[150],"combination":[153,212],"caused":[158],"marked":[159],"within":[162,238],"NMIBC":[163],"tissue":[164,196],"biopsies":[165],"upregulating":[167],"IFN-inducible":[168],"genes,":[169],"including":[170],"both":[171],"immune":[172],"checkpoint":[173],"inhibitory":[174],"genes":[175],"(PD-L1":[176],"LAG3)":[178],"Th1-associated":[180],"chemokines,":[181],"well":[183],"innate":[189],"activator":[190],"RIG-I,":[191],"compared":[192],"from":[197,208],"untreated":[198],"patients.":[199],"No":[200],"significant":[201],"toxicities":[202],"reported":[204],"any":[206],"patient,":[207],"virus":[210],"therapy.":[213],"Conclusions:":[214],"acceptable":[216],"profile":[218],"CAVATAK,":[220],"proof":[221],"targeting,":[224],"cell":[228],"death":[229],"together":[230],"virus-mediated":[233],"increases":[234],"\u201cimmunological":[236],"heat\u201d":[237],"microenvironment":[241],"all":[242],"indicate":[243],"that":[244],"may":[246],"be":[247],"potentially":[248],"considered":[249],"therapeutic":[253],"for":[254],"NMIBC.":[255]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}