{"id":"https://openalex.org/W4361946367","doi":"https://doi.org/10.1158/1078-0432.c.6526211","title":"Data from BATON-CRC: A Phase II Randomized Trial Comparing Tivozanib Plus mFOLFOX6 with Bevacizumab Plus mFOLFOX6 in Stage IV Metastatic Colorectal Cancer","display_name":"Data from BATON-CRC: A Phase II Randomized Trial Comparing Tivozanib Plus mFOLFOX6 with Bevacizumab Plus mFOLFOX6 in Stage IV Metastatic Colorectal Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361946367","doi":"https://doi.org/10.1158/1078-0432.c.6526211"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6526211","doi":"https://doi.org/10.1158/1078-0432.c.6526211","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526211","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6526211","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5029706633","display_name":"Al B. Benson","orcid":"https://orcid.org/0000-0001-5485-7227","observed_orcids":["https://orcid.org/0000-0001-5485-7227"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Al B. Benson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039214402","display_name":"Igor Ki\u0161\u0161","orcid":"https://orcid.org/0000-0001-7693-0659","observed_orcids":["https://orcid.org/0000-0001-7693-0659"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Igor Kiss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083898918","display_name":"John A. Bridgewater","orcid":"https://orcid.org/0000-0001-9186-1604","observed_orcids":["https://orcid.org/0000-0001-9186-1604"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Bridgewater","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112538610","display_name":"Ferry A.L.M. Eskens","orcid":"https://orcid.org/0009-0000-3870-5100","observed_orcids":["https://orcid.org/0009-0000-3870-5100"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ferry A.L.M. Eskens","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084875671","display_name":"Carolyn Sasse","orcid":"https://orcid.org/0000-0001-5883-7477","observed_orcids":["https://orcid.org/0000-0001-5883-7477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn Sasse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056863172","display_name":"Sandra Vossen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra Vossen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100639654","display_name":"Jihong Chen","orcid":"https://orcid.org/0000-0002-1676-5732","observed_orcids":["https://orcid.org/0000-0002-1676-5732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jihong Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833408","display_name":"Chip Van Sant","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chip Van Sant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Howard A. Ball","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard A. Ball","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006540113","display_name":"Anne Therese Keating","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne Keating","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5076368703","display_name":"Andrew Krivoshik","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Krivoshik","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tivozanib","display_name":"tivozanib","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9440000057220459},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/mfolfox6","display_name":"mFOLFOX6","score":0.9470000267028809},{"id":"https://openalex.org/keywords/vegfr-tyrosine-kinase-inhibitors","display_name":"VEGFR inhibitors","score":0.8460000157356262},{"id":"https://openalex.org/keywords/neuropilin-1","display_name":"neuropilin-1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9490000009536743},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.531000018119812},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.5759999752044678},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.33000001311302185},{"id":"https://openalex.org/keywords/trial-discontinuation","display_name":"trial discontinuation","score":0.597000002861023},{"id":"https://openalex.org/keywords/overall-response-rate","display_name":"overall response rate","score":0.6069999933242798},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6779999732971191},{"id":"https://openalex.org/keywords/time-to-treatment-failure","display_name":"time to treatment failure","score":0.8320000171661377},{"id":"https://openalex.org/keywords/duration-of-response","display_name":"duration of response","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.8421304225921631},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6793513298034668},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5568013191223145},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5447301864624023},{"id":"https://openalex.org/C61943457","wikidata":"https://www.wikidata.org/wiki/Q6046661","display_name":"Interim analysis","level":3,"score":0.5402010083198547},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5362728238105774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5158742666244507},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5073689818382263},{"id":"https://openalex.org/C31760486","wikidata":"https://www.wikidata.org/wiki/Q7180990","display_name":"Phases of clinical research","level":3,"score":0.4415787160396576},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42429274320602417},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.26226556301116943},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.22092148661613464},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.19746246933937073},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6526211","doi":"https://doi.org/10.1158/1078-0432.c.6526211","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526211","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6526211.v1","doi":"https://doi.org/10.1158/1078-0432.c.6526211.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526211.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6526211","doi":"https://doi.org/10.1158/1078-0432.c.6526211","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526211","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2468227431","https://openalex.org/W2343129507","https://openalex.org/W2303847621","https://openalex.org/W2467590014","https://openalex.org/W4361927513","https://openalex.org/W2597492983","https://openalex.org/W2170957850","https://openalex.org/W2389239223","https://openalex.org/W1504745397","https://openalex.org/W2528632433"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Tivozanib,":[2],"a":[3,26,181,267],"selective":[4],"inhibitor":[5],"of":[6,36,63,106,129,218,249,257],"VEGFR-1,":[7],"-2,":[8],"and":[9,25,112,162,203,211,254],"-3,":[10],"plus":[11,67],"mFOLFOX6":[12,59],"in":[13,40,135,160,184,187,195,228,247],"an":[14],"advanced":[15],"gastrointestinal":[16],"cancer":[17,47],"phase":[18,33],"Ib":[19],"study":[20],"had":[21],"encouraging":[22],"antineoplastic":[23],"activity":[24,51],"tolerable":[27,202],"safety":[28,253],"profile.":[29],"This":[30],"randomized,":[31],"open-label,":[32],"II":[34],"trial":[35],"tivozanib/mFOLFOX6":[37,130,219,258],"versus":[38,52,145],"bevacizumab/mFOLFOX6":[39,132,210,227],"patients":[41,57,188,196,229],"with":[42,165,189,197,208,222,230,261],"previously":[43,231],"untreated":[44,232],"metastatic":[45],"colorectal":[46],"(mCRC)":[48],"evaluated":[49],"tivozanib":[50,69,213,263,272],"bevacizumab.":[53],"Experimental":[54],"Design:":[55],"Treatment-na\u00efve":[56],"received":[58],"every":[60,83],"2":[61,84],"weeks":[62],"each":[64],"28-day":[65],"cycle":[66],"either":[68],"orally":[70],"1.5":[71],"mg":[72],"once":[73],"daily":[74],"for":[75,127,133,271],"21":[76],"days":[77],"or":[78],"bevacizumab":[79],"intravenously":[80],"5":[81],"mg/kg":[82],"weeks.":[85],"Investigator-assessed":[86],"progression-free":[87],"survival":[88],"(PFS)":[89],"was":[90,139,143,201,220,259],"the":[91,124,136,237,250],"primary":[92],"endpoint;":[93],"some":[94],"secondary":[95],"endpoints":[96],"included":[97],"safety,":[98],"overall":[99,101],"survival,":[100],"response":[102],"rate":[103],"(ORR),":[104],"duration":[105],"response,":[107],"time":[108],"to":[109,226],"treatment":[110],"failure,":[111],"biomarker":[113,169,270],"subgroup":[114],"analyses.":[115],"Results:":[116],"A":[117],"prespecified":[118,238],"interim":[119,167,239],"futility":[120,125],"analysis":[121,240],"demonstrated":[122,180],"that":[123],"boundary":[126],"superiority":[128],"over":[131],"PFS":[134,142,161,174,186],"intent-to-treat":[137],"population":[138],"crossed;":[140],"median":[141],"9.4":[144],"10.7":[146],"months":[147],"[HR":[148],"=":[149,156],"1.091;":[150],"confidence":[151],"interval":[152],"(CI),":[153],"0.693\u20131.718;":[154],"P":[155],"0.706].":[157],"Tivozanib/mFOLFOX6":[158,200],"resulted":[159,246],"ORR":[163],"comparable":[164,207,221],"bevacizumab/mFOLFOX6;":[166],"analyses":[168,179],"results":[170,276],"revealed":[171],"no":[172],"significant":[173],"association.":[175],"Post":[176],"hoc":[177],"final":[178],"potential":[182,268],"difference":[183],"tivozanib-specific":[185],"low":[190],"neuropilin-1":[191],"(NRP-1),":[192],"but":[193,223,274],"not":[194,224,242],"high":[198],"NRP-1.":[199],"adverse":[204],"events":[205],"were":[206],"both":[209],"previous":[212],"studies.":[214],"Conclusions:":[215],"The":[216,252],"efficacy":[217],"superior":[225],"mCRC.":[233],"Since":[234],"data":[235],"from":[236],"did":[241],"demonstrate":[243],"superiority,":[244],"this":[245],"discontinuation":[248],"study.":[251],"tolerability":[255],"profile":[256],"consistent":[260],"other":[262],"trials.":[264],"NRP-1":[265],"is":[266],"predictive":[269],"activity,":[273],"these":[275],"require":[277],"further":[278],"validation.":[279],"Clin":[280],"Cancer":[281],"Res;":[282],"22(20);":[283],"5058\u201367.":[284],"\u00a92016":[285],"AACR.":[286]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
