{"id":"https://openalex.org/W4361946192","doi":"https://doi.org/10.1158/1078-0432.c.6526775","title":"Data from Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082)","display_name":"Data from Phase II Study of Radiotherapy and Temsirolimus versus Radiochemotherapy with Temozolomide in Patients with Newly Diagnosed Glioblastoma without MGMT Promoter Hypermethylation (EORTC 26082)","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361946192","doi":"https://doi.org/10.1158/1078-0432.c.6526775"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6526775","doi":"https://doi.org/10.1158/1078-0432.c.6526775","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526775","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6526775","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080482957","display_name":"Wolfgang Wick","orcid":"https://orcid.org/0000-0002-6171-634X","observed_orcids":["https://orcid.org/0000-0002-6171-634X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang Wick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038129366","display_name":"Thierry Gorlia","orcid":"https://orcid.org/0009-0009-9159-2761","observed_orcids":["https://orcid.org/0009-0009-9159-2761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thierry Gorlia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075134142","display_name":"Pierre Bady","orcid":"https://orcid.org/0000-0003-1398-4689","observed_orcids":["https://orcid.org/0000-0003-1398-4689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Bady","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064778456","display_name":"Michael Platten","orcid":"https://orcid.org/0000-0002-4746-887X","observed_orcids":["https://orcid.org/0000-0002-4746-887X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Platten","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010891460","display_name":"Martin J. van den Bent","orcid":"https://orcid.org/0000-0001-5710-5127","observed_orcids":["https://orcid.org/0000-0001-5710-5127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin J. van den Bent","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056837393","display_name":"MARTIN J.B. TAPHOORN","orcid":"https://orcid.org/0000-0001-9949-4722","observed_orcids":["https://orcid.org/0000-0001-9949-4722"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin J.B. Taphoorn","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020945789","display_name":"Jonathan Steuve","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Steuve","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087336206","display_name":"Alba Ariela Brandes","orcid":"https://orcid.org/0000-0002-2503-9089","observed_orcids":["https://orcid.org/0000-0002-2503-9089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alba A. Brandes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113461557","display_name":"Marie\u2010France Hamou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marie-France Hamou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040945122","display_name":"Antje Wick","orcid":"https://orcid.org/0000-0003-0020-6386","observed_orcids":["https://orcid.org/0000-0003-0020-6386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antje Wick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Markus Kosch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Kosch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017177249","display_name":"Michael Weller","orcid":"https://orcid.org/0000-0002-1748-174X","observed_orcids":["https://orcid.org/0000-0002-1748-174X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Weller","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053052330","display_name":"Roger Stupp","orcid":"https://orcid.org/0000-0002-5483-3118","observed_orcids":["https://orcid.org/0000-0002-5483-3118"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roger Stupp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107954302","display_name":"Patrick Roth","orcid":"https://orcid.org/0000-0003-3897-214X","observed_orcids":["https://orcid.org/0000-0003-3897-214X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patrick Roth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109121280","display_name":"Vassilis Golfinopoulos","orcid":"https://orcid.org/0000-0002-8667-9477","observed_orcids":["https://orcid.org/0000-0002-8667-9477"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vassilis Golfinopoulos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039803490","display_name":"Jean\u2010S\u00e9bastien Frenel","orcid":"https://orcid.org/0000-0002-5273-0561","observed_orcids":["https://orcid.org/0000-0002-5273-0561"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Sebastien Frenel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071553983","display_name":"Mario Campone","orcid":"https://orcid.org/0000-0002-5196-5908","observed_orcids":["https://orcid.org/0000-0002-5196-5908"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Campone","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006893068","display_name":"Damien Ricard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Damien Ricard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053746026","display_name":"Christine Marosi","orcid":"https://orcid.org/0000-0003-0631-672X","observed_orcids":["https://orcid.org/0000-0003-0631-672X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Marosi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101638916","display_name":"S. Vill\u00e0","orcid":"https://orcid.org/0000-0002-9089-4807","observed_orcids":["https://orcid.org/0000-0002-9089-4807","https://orcid.org/0000-0002-8034-2603"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvador Villa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032459039","display_name":"Astrid Weyerbrock","orcid":"https://orcid.org/0000-0001-9060-4462","observed_orcids":["https://orcid.org/0000-0001-9060-4462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Astrid Weyerbrock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109583251","display_name":"Kirsten Hopkins","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kirsten Hopkins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048798659","display_name":"Kriszti\u00e1n Homicsk\u00f3","orcid":"https://orcid.org/0000-0003-0912-6198","observed_orcids":["https://orcid.org/0000-0003-0912-6198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krisztian Homicsko","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022713255","display_name":"Beno\u00eet Lhermitte","orcid":"https://orcid.org/0000-0002-4884-3758","observed_orcids":["https://orcid.org/0000-0002-4884-3758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benoit Lhermitte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004254984","display_name":"Gianfranco Angelo Pesce","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianfranco Pesce","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5048627921","display_name":"Monika E. Hegi","orcid":"https://orcid.org/0000-0003-0855-6495","observed_orcids":["https://orcid.org/0000-0003-0855-6495"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monika E. Hegi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9800000190734863},{"id":"https://openalex.org/keywords/temsirolimus","display_name":"temsirolimus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.7509999871253967},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.640999972820282},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.8759999871253967},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6980000138282776},{"id":"https://openalex.org/keywords/mtor-phosphorylation","display_name":"mTOR phosphorylation","score":0.7360000014305115},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.75},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.5820000171661377},{"id":"https://openalex.org/keywords/newly-diagnosed-glioblastoma","display_name":"newly diagnosed glioblastoma","score":0.6940000057220459},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.48899999260902405},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.35899999737739563}],"concepts":[{"id":"https://openalex.org/C2777389519","wikidata":"https://www.wikidata.org/wiki/Q425088","display_name":"Temozolomide","level":3,"score":0.7476895451545715},{"id":"https://openalex.org/C2776820818","wikidata":"https://www.wikidata.org/wiki/Q7699074","display_name":"Temsirolimus","level":5,"score":0.739840030670166},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6712761521339417},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5448765754699707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5437433123588562},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.4385470747947693},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.41206592321395874},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3892388343811035},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34743332862854004},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2651296854019165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1656123399734497},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.10127818584442139},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6526775","doi":"https://doi.org/10.1158/1078-0432.c.6526775","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526775","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6526775.v1","doi":"https://doi.org/10.1158/1078-0432.c.6526775.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6526775.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6526775","doi":"https://doi.org/10.1158/1078-0432.c.6526775","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526775","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2346904924","https://openalex.org/W2400978889","https://openalex.org/W6986654802","https://openalex.org/W2076491810","https://openalex.org/W4286294603","https://openalex.org/W4242815556","https://openalex.org/W4361931258","https://openalex.org/W4225008551","https://openalex.org/W2020129281","https://openalex.org/W2029308958"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"EORTC":[2],"26082":[3],"assessed":[4],"the":[5,79,91,136,141,153,178,187,250],"activity":[6],"of":[7,87,99,105,122,125,158,204,210,247],"temsirolimus":[8,55,137,163,188],"in":[9,78,95,135,177,186,212,224,239,249],"patients":[10,73,89,150,160,240],"with":[11,36,49,119,162,228,241],"newly":[12],"diagnosed":[13],"glioblastoma":[14,39],"harboring":[15],"an":[16,242],"unmethylated":[17,38,243],"O6":[18],"methylguanine-DNA-methyltransferase":[19],"(MGMT)":[20],"promoter.":[21,245],"Experimental":[22],"Design:":[23],"Patients":[24,35],"(n":[25,40],"=":[26,41,198,221],"257)":[27],"fulfilling":[28],"eligibility":[29],"criteria":[30],"underwent":[31],"central":[32],"MGMT":[33,37,244],"testing.":[34],"111)":[42],"were":[43,110,115],"randomized":[44],"1:1":[45],"between":[46],"standard":[47,139],"chemo-radiotherapy":[48],"temozolomide":[50,179,238],"or":[51,146],"radiotherapy":[52],"plus":[53],"weekly":[54],"(25":[56],"mg).":[57],"Primary":[58],"endpoint":[59],"was":[60,70,130,170,226,234],"overall":[61],"survival":[62,169],"at":[63,75],"12":[64,76],"months":[65,77],"(OS12).":[66],"A":[67,83],"positive":[68],"signal":[69],"considered":[71],">38":[72],"alive":[74],"per":[80,117,154],"protocol":[81,118,155],"population.":[82],"noncomparative":[84],"reference":[85],"arm":[86,180,189],"54":[88,159],"evaluated":[90],"assumptions":[92],"on":[93],"OS12":[94],"a":[96,120,256],"standard-treated":[97],"cohort":[98],"patients.":[100],"Prespecified":[101],"post":[102],"hoc":[103],"analyses":[104,203],"markers":[106],"reflecting":[107],"target":[108],"activation":[109],"performed.":[111],"Results:":[112],"Both":[113],"therapies":[114],"administered":[116],"median":[121],"13":[123],"cycles":[124],"maintenance":[126],"temsirolimus.":[127,231],"Median":[128],"age":[129],"55":[131],"and":[132,138,181,206],"58":[133],"years":[134],"arms,":[140],"WHO":[142],"performance":[143],"status":[144],"0":[145],"1":[147],"for":[148],"most":[149],"(95.5%).":[151],"In":[152,200],"population,":[156],"38":[157],"treated":[161],"reached":[164],"OS12.":[165],"The":[166],"actuarial":[167],"1-year":[168],"72.2%":[171],"[95%":[172],"confidence":[173],"interval":[174],"(CI),":[175],"58.2\u201382.2]":[176],"69.6%":[182],"(95%":[183],"CI,":[184,195,218],"55.8\u201379.9)":[185],"[hazard":[190],"ratio":[191],"(HR)":[192],"1.16;":[193],"95%":[194,217],"0.77\u20131.76;":[196],"P":[197,220],"0.47].":[199],"multivariable":[201],"prognostic":[202],"clinical":[205],"molecular":[207],"factors,":[208],"phosphorylation":[209],"mTORSer2448":[211,248],"tumor":[213,252],"tissue":[214,253],"(HR":[215],"0.13;":[216],"0.04\u20130.47;":[219],"0.002),":[222],"detected":[223],"37.6%,":[225],"associated":[227],"benefit":[229],"from":[230,259],"Conclusions:":[232],"Temsirolimus":[233],"not":[235],"superior":[236],"to":[237],"Phosphorylation":[246],"pretreatment":[251],"may":[254],"define":[255],"subgroup":[257],"benefitting":[258],"mTOR":[260],"inhibition.":[261],"Clin":[262],"Cancer":[263],"Res;":[264],"22(19);":[265],"4797\u2013806.":[266],"\u00a92016":[267],"AACR.":[268]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}