{"id":"https://openalex.org/W4361946153","doi":"https://doi.org/10.1158/1078-0432.c.6526403","title":"Data from Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes","display_name":"Data from Molecular Differences between Screen-Detected and Interval Breast Cancers Are Largely Explained by PAM50 Subtypes","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361946153","doi":"https://doi.org/10.1158/1078-0432.c.6526403"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6526403","doi":"https://doi.org/10.1158/1078-0432.c.6526403","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526403","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6526403","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018786162","display_name":"Jingmei Li","orcid":"https://orcid.org/0000-0001-8587-7511","observed_orcids":["https://orcid.org/0000-0001-8587-7511"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingmei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028678617","display_name":"Emma L. Ivansson","orcid":"https://orcid.org/0000-0002-4630-1576","observed_orcids":["https://orcid.org/0000-0002-4630-1576"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma Ivansson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080562087","display_name":"Daniel Klevebring","orcid":"https://orcid.org/0000-0002-9810-3838","observed_orcids":["https://orcid.org/0000-0002-9810-3838"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Klevebring","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012121976","display_name":"Nicholas P. Tobin","orcid":"https://orcid.org/0000-0003-2343-9772","observed_orcids":["https://orcid.org/0000-0003-2343-9772"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas P. Tobin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004617633","display_name":"Linda Sofie Lindstr\u00f6m","orcid":"https://orcid.org/0000-0002-7722-7532","observed_orcids":["https://orcid.org/0000-0002-7722-7532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Linda Sofie Lindstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Johanna Holm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna Holm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089447800","display_name":"Gabriela Prochazka","orcid":"https://orcid.org/0009-0009-4534-1101","observed_orcids":["https://orcid.org/0009-0009-4534-1101"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriela Prochazka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009406341","display_name":"Camilla Cristando","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Camilla Cristando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028045092","display_name":"Juni Palmgren","orcid":"https://orcid.org/0000-0002-9031-8615","observed_orcids":["https://orcid.org/0000-0002-9031-8615"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juni Palmgren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111948452","display_name":"Sven T\u00f6rnberg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sven T\u00f6rnberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018316113","display_name":"Keith Humphreys","orcid":"https://orcid.org/0000-0002-7458-8252","observed_orcids":["https://orcid.org/0000-0002-7458-8252"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith Humphreys","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008654654","display_name":"Johan Hartman","orcid":"https://orcid.org/0000-0002-6500-8527","observed_orcids":["https://orcid.org/0000-0002-6500-8527"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johan Hartman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045953017","display_name":"Jan Frisell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jan Frisell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046937219","display_name":"Mattias Rantalainen","orcid":"https://orcid.org/0000-0002-7740-2986","observed_orcids":["https://orcid.org/0000-0002-7740-2986"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mattias Rantalainen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031466516","display_name":"Johan Lindberg","orcid":"https://orcid.org/0000-0003-3610-6774","observed_orcids":["https://orcid.org/0000-0003-3610-6774"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johan Lindberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053177403","display_name":"Per N Hall","orcid":"https://orcid.org/0000-0002-5640-9126","observed_orcids":["https://orcid.org/0000-0002-5640-9126"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Per Hall","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071571360","display_name":"Jonas C. S. Bergh","orcid":"https://orcid.org/0000-0001-5526-1847","observed_orcids":["https://orcid.org/0000-0001-5526-1847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonas Bergh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021982213","display_name":"Henrik Gr\u00f6nberg","orcid":"https://orcid.org/0000-0002-1073-2753","observed_orcids":["https://orcid.org/0000-0002-1073-2753"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henrik Gr\u00f6nberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5040540995","display_name":"Kamila Czene","orcid":"https://orcid.org/0000-0002-3233-5695","observed_orcids":["https://orcid.org/0000-0002-3233-5695"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kamila Czene","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.44600000977516174,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.44600000977516174,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.4115999937057495,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interval-breast-cancer","display_name":"interval breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/screen-detected-breast-cancer","display_name":"screen-detected breast cancer","score":0.9950000047683716},{"id":"https://openalex.org/keywords/pam50-subtypes","display_name":"PAM50 molecular subtypes","score":0.9459999799728394},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9419999718666077},{"id":"https://openalex.org/keywords/tp53","display_name":"TP53","score":0.8109999895095825},{"id":"https://openalex.org/keywords/kmt2b","display_name":"KMT2B","score":0.9990000128746033},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.8799999952316284},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8610000014305115},{"id":"https://openalex.org/keywords/breast-density","display_name":"breast density","score":0.8090000152587891},{"id":"https://openalex.org/keywords/breast-cancer-subtyping","display_name":"breast cancer subtyping","score":0.42500001192092896}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7745463848114014},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5347705483436584},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5036241412162781},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5003070831298828},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.441667377948761},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43826085329055786},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.38099485635757446},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37655261158943176},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.324715793132782},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.23558980226516724},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19596388936042786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6526403","doi":"https://doi.org/10.1158/1078-0432.c.6526403","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526403","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6526403","doi":"https://doi.org/10.1158/1078-0432.c.6526403","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6526403","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2518034712","https://openalex.org/W2592329789","https://openalex.org/W2394653779","https://openalex.org/W4392721881","https://openalex.org/W2891052925","https://openalex.org/W3030853384","https://openalex.org/W3001432734","https://openalex.org/W4319160107","https://openalex.org/W2091813190","https://openalex.org/W4247364833"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Interval":[2],"breast":[3,73,82,96],"cancer":[4,74,83,138,228],"is":[5,60],"of":[6,24,40,55,70,78,94,101,116,178,203],"clinical":[7,64],"interest,":[8],"as":[9],"it":[10],"exhibits":[11],"an":[12,209],"aggressive":[13,45],"phenotype":[14],"and":[15,63,86,106,122,133,142,155,190],"evades":[16],"detection":[17],"by":[18,136,226,237],"screening":[19,35],"mammography.":[20],"A":[21,92],"comprehensive":[22],"picture":[23],"somatic":[25,128,170],"changes":[26],"that":[27],"drive":[28],"tumors":[29,97],"to":[30,126],"become":[31],"symptomatic":[32],"in":[33,50,57,88,130,162,166,188,192,208],"the":[34,41,67,89,131,150,183,246,250],"interval":[36,109,137,163,227],"can":[37],"improve":[38],"understanding":[39],"biology":[42],"underlying":[43],"these":[44],"tumors.":[46],"Experimental":[47],"Design:":[48],"Initiated":[49],"April":[51],"2013,":[52],"Clinical":[53],"Sequencing":[54],"Cancer":[56,255],"Sweden":[58],"(Clinseq)":[59],"a":[61,175],"scientific":[62],"platform":[65],"for":[66,215],"genomic":[68,132],"profiling":[69],"cancer.":[71],"The":[72],"pilot":[75],"study":[76],"consisted":[77],"women":[79],"diagnosed":[80],"with":[81,174],"between":[84,182,249],"2001":[85],"2012":[87],"Stockholm/Gotland":[90],"regions.":[91],"subset":[93],"307":[95],"was":[98],"successfully":[99],"sequenced,":[100],"which":[102,204],"113":[103],"were":[104,108,146,157,206,219,230,234],"screen-detected":[105,167],"60":[107],"cancers.":[110,168],"We":[111],"applied":[112],"targeted":[113],"deep":[114],"sequencing":[115,124],"cancer-related":[117],"genes;":[118],"low-pass,":[119],"whole-genome":[120],"sequencing;":[121],"RNA":[123],"technology":[125],"characterize":[127],"differences":[129,218,225,248],"transcriptomic":[134],"architecture":[135],"status.":[139],"Mammographic":[140],"density":[141],"PAM50":[143,238],"molecular":[144],"subtypes":[145],"considered.":[147],"Results:":[148],"In":[149],"univariate":[151],"analyses,":[152],"TP53,":[153],"PPP1R3A,":[154],"KMT2B":[156],"significantly":[158,199],"more":[159],"frequently":[160],"mutated":[161],"cancers":[164],"than":[165],"Acquired":[169],"copy":[171],"number":[172],"aberrations":[173],"frequency":[176],"difference":[177],"at":[179],"least":[180],"15%":[181],"two":[184,251],"groups":[185],"included":[186],"gains":[187],"17q23-q25.3":[189],"losses":[191],"16q24.2.":[193],"Gene":[194],"expression":[195],"analysis":[196],"identified":[197],"447":[198],"differentially":[200],"expressed":[201],"genes,":[202],"120":[205],"replicated":[207],"independent":[210],"microarray":[211],"dataset.":[212],"After":[213],"adjusting":[214],"PAM50,":[216],"most":[217],"no":[220],"longer":[221],"significant.":[222],"Conclusions:":[223],"Molecular":[224],"status":[229],"observed,":[231],"but":[232],"they":[233],"largely":[235],"explained":[236],"subtypes.":[239],"This":[240],"work":[241],"offers":[242],"new":[243],"insights":[244],"into":[245],"biological":[247],"tumor":[252],"groups.":[253],"Clin":[254],"Res;":[256],"23(10);":[257],"2584\u201392.":[258],"\u00a92016":[259],"AACR.":[260]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-04-05T00:00:00"}