{"id":"https://openalex.org/W4361945702","doi":"https://doi.org/10.1158/1078-0432.c.6524264","title":"Data from Not all NOTCH Is Created Equal: The Oncogenic Role of NOTCH2 in Bladder Cancer and Its Implications for Targeted Therapy","display_name":"Data from Not all NOTCH Is Created Equal: The Oncogenic Role of NOTCH2 in Bladder Cancer and Its Implications for Targeted Therapy","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361945702","doi":"https://doi.org/10.1158/1078-0432.c.6524264"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6524264","doi":"https://doi.org/10.1158/1078-0432.c.6524264","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6524264","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6524264","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016698641","display_name":"Tetsutaro Hayashi","orcid":"https://orcid.org/0000-0003-1679-5525","observed_orcids":["https://orcid.org/0000-0003-1679-5525"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tetsutaro Hayashi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080606297","display_name":"Kilian Martin Gust","orcid":"https://orcid.org/0000-0002-5780-2878","observed_orcids":["https://orcid.org/0000-0002-5780-2878"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kilian M. Gust","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055207707","display_name":"Alexander William Wyatt","orcid":"https://orcid.org/0000-0003-2399-0329","observed_orcids":["https://orcid.org/0000-0003-2399-0329"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander W. Wyatt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038259156","display_name":"Akihiro Goriki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akihiro Goriki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078386378","display_name":"Wolfgang J\u00e4ger","orcid":"https://orcid.org/0000-0002-2841-2125","observed_orcids":["https://orcid.org/0000-0002-2841-2125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wolfgang J\u00e4ger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025788173","display_name":"Shannon J. Awrey","orcid":"https://orcid.org/0000-0001-9905-6853","observed_orcids":["https://orcid.org/0000-0001-9905-6853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shannon Awrey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368210","display_name":"Na Li","orcid":"https://orcid.org/0000-0003-3619-7899","observed_orcids":["https://orcid.org/0000-0003-3619-7899"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Na Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051781768","display_name":"Htoo Zarni Oo","orcid":"https://orcid.org/0009-0009-8514-2713","observed_orcids":["https://orcid.org/0009-0009-8514-2713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Htoo Zarni Oo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057264757","display_name":"Manuel Altamirano-Dimas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Altamirano-Dimas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088350338","display_name":"Ralph Buttyan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph Buttyan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034110828","display_name":"Ladan Fazli","orcid":"https://orcid.org/0009-0005-0731-0583","observed_orcids":["https://orcid.org/0009-0005-0731-0583","https://orcid.org/0000-0001-6488-4245"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ladan Fazli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112277964","display_name":"Akio Matsubara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Akio Matsubara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050196540","display_name":"Peter C. Black","orcid":"https://orcid.org/0000-0002-2919-7068","observed_orcids":["https://orcid.org/0000-0002-2919-7068"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter C. Black","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10458","display_name":"Bladder and Urothelial Cancer Treatments","score":0.8812999725341797,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.05869999900460243,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch2","display_name":"Notch2","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bladder-cancer","display_name":"bladder cancer","score":0.9929999709129333},{"id":"https://openalex.org/keywords/oncogenes","display_name":"oncogenes","score":0.7570000290870667},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.8240000009536743},{"id":"https://openalex.org/keywords/copy-number-gain","display_name":"copy number gain","score":0.8410000205039978},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.699999988079071},{"id":"https://openalex.org/keywords/cancer-stemness","display_name":"cancer stemness","score":0.7979999780654907},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.5830000042915344},{"id":"https://openalex.org/keywords/basal-subtype","display_name":"basal subtype","score":0.5830000042915344},{"id":"https://openalex.org/keywords/mesenchymal-subtype","display_name":"mesenchymal subtype","score":0.8650000095367432},{"id":"https://openalex.org/keywords/csl-transcription-factor","display_name":"CSL transcription factor","score":0.40400001406669617}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6353554725646973},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.6069451570510864},{"id":"https://openalex.org/C2780352672","wikidata":"https://www.wikidata.org/wiki/Q504775","display_name":"Bladder cancer","level":3,"score":0.5832478404045105},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.5492010116577148},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5340486764907837},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4809826612472534},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.45227178931236267},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.4466615915298462},{"id":"https://openalex.org/C2778287671","wikidata":"https://www.wikidata.org/wiki/Q7852676","display_name":"Tumor initiation","level":4,"score":0.4248560965061188},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.42293447256088257},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4219011664390564},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3247494399547577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31301623582839966},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31191176176071167},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.10620686411857605},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6524264","doi":"https://doi.org/10.1158/1078-0432.c.6524264","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6524264","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6524264","doi":"https://doi.org/10.1158/1078-0432.c.6524264","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6524264","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2233600556","https://openalex.org/W2589532182","https://openalex.org/W2797719163","https://openalex.org/W3022842351","https://openalex.org/W2262180324","https://openalex.org/W3012557471","https://openalex.org/W2940016210","https://openalex.org/W2332584425","https://openalex.org/W2135732675","https://openalex.org/W2005925039"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Recent":[2],"molecular":[3],"analyses":[4],"of":[5,56,82,118,122,134,146,167,181,237,240],"bladder":[6,26,48,88,226,250],"cancer":[7,227],"open":[8],"the":[9,97,119,150,155,176,186,210],"door":[10],"to":[11,64],"significant":[12],"advances":[13],"in":[14,25,47,72,87,96,101,206,209],"targeted":[15],"therapies.":[16],"NOTCH":[17,157],"has":[18],"been":[19],"identified":[20,94],"as":[21,221],"a":[22,79,194,243],"tumor":[23,61],"suppressor":[24],"cancer,":[27],"but":[28],"prior":[29],"reports":[30],"have":[31,216],"focused":[32],"on":[33],"NOTCH1.":[34],"Here":[35],"we":[36,183],"hypothesized":[37],"that":[38,149,218,224],"NOTCH2":[39,65,70,83,91,104,123,219,241],"is":[40,242],"an":[41,161,222],"oncogene":[42,223],"suitable":[43],"for":[44,178,248],"therapeutic":[45,179],"targeting":[46,180],"cancer.":[49,89,251],"Experimental":[50],"design:":[51],"We":[52,77,215],"studied":[53,69],"genomic":[54],"aberrations":[55],"NOTCH,":[57],"compared":[58],"survival":[59],"and":[60,68,74,100,111,128,136,172,190,204,208,229,235],"progression":[62],"according":[63],"expression":[66,92],"levels,":[67],"function":[71],"vitro":[73,207],"vivo.":[75],"Results:":[76],"report":[78],"high":[80],"rate":[81],"copy":[84],"number":[85],"gain":[86],"High":[90],"was":[93],"especially":[95],"basal":[98],"subtype":[99],"mesenchymal":[102],"tumors.":[103],"activation":[105],"correlated":[106],"with":[107,188,193],"adverse":[108],"disease":[109],"parameters":[110],"worse":[112],"prognosis":[113],"by":[114,130,144],"immunohistochemistry.":[115],"Forced":[116],"overexpression":[117,166],"intracellular":[120],"domain":[121],"(N2ICD)":[124],"induced":[125],"cell":[126,201],"growth":[127,228],"invasion":[129],"cell-cycle":[131,233],"progression,":[132,234],"maintenance":[133,236],"stemness":[135],"epithelial-to-mesenchymal":[137],"transition":[138],"(EMT).":[139],"These":[140],"effects":[141,151],"were":[142,152],"abrogated":[143],"silencing":[145],"CSL,":[147],"indicating":[148],"mediated":[153],"through":[154,231],"canonical":[156],"signaling":[158],"pathway.":[159],"In":[160],"orthotopic":[162,211],"xenograft":[163,212],"model,":[164],"forced":[165],"N2ICD":[168],"increased":[169],"growth,":[170,202],"invasion,":[171,203],"metastasis.":[173],"To":[174],"explore":[175],"potential":[177],"NOTCH2,":[182],"first":[184],"silenced":[185],"receptor":[187],"shRNA":[189],"subsequently":[191],"treated":[192],"specific":[195],"inhibitory":[196],"antibody.":[197],"Both":[198],"interventions":[199],"decreased":[200],"metastasis":[205,230],"model.":[213],"Conclusions:":[214],"demonstrated":[217],"acts":[220],"promotes":[225],"EMT,":[232],"stemness.":[238],"Inhibition":[239],"rational":[244],"novel":[245],"treatment":[246],"strategy":[247],"invasive":[249],"Clin":[252],"Cancer":[253],"Res;":[254],"22(12);":[255],"2981\u201392.":[256],"\u00a92016":[257],"AACR.":[258]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-04-05T00:00:00"}
