{"id":"https://openalex.org/W4361945625","doi":"https://doi.org/10.1158/1078-0432.c.6525090","title":"Data from Head and Neck Squamous Cell Carcinomas Are Characterized by a Stable Immune Signature Within the Primary Tumor Over Time and Space","display_name":"Data from Head and Neck Squamous Cell Carcinomas Are Characterized by a Stable Immune Signature Within the Primary Tumor Over Time and Space","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361945625","doi":"https://doi.org/10.1158/1078-0432.c.6525090"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6525090","doi":"https://doi.org/10.1158/1078-0432.c.6525090","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525090","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6525090","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006061539","display_name":"Oliver Wood","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Oliver Wood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110895829","display_name":"James Stanier Clarke","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Clarke","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102871666","display_name":"Jeongmin Woo","orcid":"https://orcid.org/0009-0001-8139-1298","observed_orcids":["https://orcid.org/0009-0001-8139-1298"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeongmin Woo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037431046","display_name":"Adal Hussain Mirza","orcid":"https://orcid.org/0000-0003-3003-4984","observed_orcids":["https://orcid.org/0000-0003-3003-4984"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adal H. Mirza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035221639","display_name":"Christopher H. Woelk","orcid":"https://orcid.org/0000-0002-1977-0502","observed_orcids":["https://orcid.org/0000-0002-1977-0502"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher H. Woelk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063219325","display_name":"Gareth J. Thomas","orcid":"https://orcid.org/0000-0003-3832-7335","observed_orcids":["https://orcid.org/0000-0003-3832-7335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gareth J. Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038173501","display_name":"Pandurangan Vijayanand","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pandurangan Vijayanand","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Emma King","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emma King","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5072238075","display_name":"Christian H. H. Ottensmeier","orcid":"https://orcid.org/0000-0003-3619-1657","observed_orcids":["https://orcid.org/0000-0003-3619-1657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian H. Ottensmeier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9678000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.02459999918937683,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11306","display_name":"Nonmelanoma Skin Cancer Studies","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-immune-signature","display_name":"tumor immune signature","score":0.8410000205039978},{"id":"https://openalex.org/keywords/intratumor-heterogeneity","display_name":"intratumoral heterogeneity","score":0.8370000123977661},{"id":"https://openalex.org/keywords/tumor-immune-microenvironment","display_name":"tumor immune microenvironment","score":0.5120000243186951},{"id":"https://openalex.org/keywords/cd8a","display_name":"CD8A","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tumor-resection","display_name":"tumor resection","score":0.42500001192092896},{"id":"https://openalex.org/keywords/immunotherapy-response","display_name":"immunotherapy response","score":0.6919999718666077},{"id":"https://openalex.org/keywords/gene-expression-variation","display_name":"gene expression variation","score":0.5019999742507935}],"concepts":[{"id":"https://openalex.org/C2776833033","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck squamous-cell carcinoma","level":4,"score":0.6325002908706665},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4823176860809326},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45190539956092834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43995481729507446},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4339807629585266},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.4339437484741211},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4253998398780823},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.42254653573036194},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40766197443008423},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.40556415915489197},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3853938579559326},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3741770386695862},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.35412895679473877},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.30911311507225037},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2643902897834778},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22481289505958557},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10254523158073425}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6525090","doi":"https://doi.org/10.1158/1078-0432.c.6525090","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525090","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6525090","doi":"https://doi.org/10.1158/1078-0432.c.6525090","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525090","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2757064227","https://openalex.org/W4308375570","https://openalex.org/W3088416571","https://openalex.org/W4413108237","https://openalex.org/W7214550219","https://openalex.org/W3202197007","https://openalex.org/W4317936185","https://openalex.org/W2947349595","https://openalex.org/W2537963082","https://openalex.org/W4411634155"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Genetic":[2],"and":[3,29,51,62,77,102,169,208,221,241],"morphologic":[4],"heterogeneity":[5,21,230],"is":[6,22],"well-documented":[7],"in":[8,26,49,125,203,253],"solid":[9],"cancers.":[10],"Immune":[11],"cells":[12],"are":[13,212],"also":[14,222],"variably":[15],"distributed":[16],"within":[17,57],"the":[18,35,42,46,91,128,132,136,205,218,243],"tumor;":[19],"this":[20],"difficult":[23],"to":[24,89,113,142],"assess":[25],"small":[27],"biopsies,":[28],"may":[30,231],"confound":[31],"our":[32],"understanding":[33],"of":[34,37,45,109,118,159,217,239,245,250],"determinants":[36],"successful":[38],"immunotherapy.":[39],"We":[40],"examined":[41],"transcriptomic":[43,61],"variability":[44],"immunologic":[47,119,229,248],"signature":[48],"head":[50],"neck":[52],"squamous":[53],"cell":[54],"carcinoma":[55],"(HNSCC)":[56],"individual":[58],"tumors":[59],"using":[60,83],"IHC":[63,114,194],"assessments.":[64],"Experimental":[65],"Design:":[66],"Forty-four":[67],"tumor":[68,207,220],"biopsies":[69],"from":[70,127,135],"16":[71],"HNSCC":[72,204,254],"patients,":[73],"taken":[74],"at":[75,79,223],"diagnosis":[76],"later":[78],"resection,":[80],"were":[81,105,139,186],"analyzed":[82],"RNA-sequencing.":[84],"Variance":[85],"filtering":[86],"was":[87,111,122],"used":[88],"identify":[90],"top":[92],"4,000":[93],"most":[94,140],"variable":[95],"genes.":[96],"Principal":[97],"component":[98],"analysis,":[99],"hierarchical":[100,164],"clustering,":[101],"correlation":[103,170],"analysis":[104,171],"performed.":[106],"Gene":[107],"expression":[108,121,162],"CD8A":[110,182],"correlated":[112,188],"analysis.":[115],"Results:":[116],"Analysis":[117],"gene":[120,161,183],"highly":[123,187],"consistent":[124],"replicates":[126],"same":[129,137,219],"cancer.":[130],"Across":[131],"cohort,":[133],"samples":[134],"patient":[138],"similar":[141],"each":[143],"other,":[144],"both":[145],"spatially":[146],"(at":[147],"diagnosis)":[148],"and,":[149],"notably,":[150],"over":[151],"time":[152],"(diagnostic":[153],"biopsy":[154],"compared":[155],"with":[156,189],"resection);":[157],"comparison":[158],"global":[160,206],"by":[163,193],"clustering":[165],"(P":[166],"\u2264":[167],"0.0001)":[168],"[median":[172],"intrapatient":[173],"r":[174,179],"=":[175,180,196],"0.82;":[176],"median":[177],"interpatient":[178],"0.63].":[181],"transcript":[184],"counts":[185,192],"CD8":[190],"T-cell":[191],"(r":[195],"0.82).":[197],"Conclusions:":[198],"Our":[199],"data":[200],"demonstrate":[201],"that":[202,228],"adaptive":[209],"immune":[210],"signatures":[211],"stable":[213],"between":[214],"discrete":[215],"parts":[216],"different":[224],"timepoints.":[225],"This":[226],"suggests":[227],"not":[232],"be":[233],"a":[234],"key":[235],"reason":[236],"for":[237,247],"failure":[238],"immunotherapy":[240],"underpins":[242],"use":[244],"transcriptomics":[246],"evaluation":[249],"novel":[251],"agents":[252],"patients.":[255],"Clin":[256],"Cancer":[257],"Res;":[258],"23(24);":[259],"7641\u20139.":[260],"\u00a92017":[261],"AACR.":[262]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2023-04-05T00:00:00"}
