{"id":"https://openalex.org/W4361945623","doi":"https://doi.org/10.1158/1078-0432.c.6523464","title":"Data from The Renin\u2013Angiotensin System Mediates EGF Receptor\u2013Vitamin D Receptor Cross-Talk in Colitis-Associated Colon Cancer","display_name":"Data from The Renin\u2013Angiotensin System Mediates EGF Receptor\u2013Vitamin D Receptor Cross-Talk in Colitis-Associated Colon Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361945623","doi":"https://doi.org/10.1158/1078-0432.c.6523464"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6523464","doi":"https://doi.org/10.1158/1078-0432.c.6523464","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6523464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6523464","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074161692","display_name":"Urszula Dougherty","orcid":"https://orcid.org/0009-0003-9321-6862","observed_orcids":["https://orcid.org/0009-0003-9321-6862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Urszula Dougherty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035049656","display_name":"Reba Mustafi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reba Mustafi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103705634","display_name":"Farhana Sadiq","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farhana Sadiq","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002536253","display_name":"Anas Almoghrabi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anas Almoghrabi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019716346","display_name":"Devkumar Mustafi","orcid":"https://orcid.org/0000-0001-7826-4485","observed_orcids":["https://orcid.org/0000-0001-7826-4485"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Devkumar Mustafi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045701517","display_name":"Maggi Kreisheh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maggi Kreisheh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040730866","display_name":"Sumana Sundaramurthy","orcid":"https://orcid.org/0009-0004-7066-5662","observed_orcids":["https://orcid.org/0009-0004-7066-5662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sumana Sundaramurthy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101480293","display_name":"Weicheng Liu","orcid":"https://orcid.org/0000-0003-1664-8728","observed_orcids":["https://orcid.org/0000-0003-1664-8728"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weicheng Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059989236","display_name":"Vani J. A. Konda","orcid":"https://orcid.org/0000-0002-9932-8780","observed_orcids":["https://orcid.org/0000-0002-9932-8780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vani J. Konda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059142660","display_name":"Joel R. Pekow","orcid":"https://orcid.org/0000-0002-4790-8994","observed_orcids":["https://orcid.org/0000-0002-4790-8994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joel Pekow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080181876","display_name":"Sharad Khare","orcid":"https://orcid.org/0000-0001-9169-2396","observed_orcids":["https://orcid.org/0000-0001-9169-2396"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sharad Khare","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044212537","display_name":"John Hart","orcid":"https://orcid.org/0000-0003-3919-8125","observed_orcids":["https://orcid.org/0000-0003-3919-8125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John Hart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035169905","display_name":"Loren J. Joseph","orcid":"https://orcid.org/0000-0002-9503-4689","observed_orcids":["https://orcid.org/0000-0002-9503-4689"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Loren Joseph","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063434268","display_name":"Alice M. Wyrwicz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alice Wyrwicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079213983","display_name":"Gregory S. Karczmar","orcid":"https://orcid.org/0000-0002-2455-5858","observed_orcids":["https://orcid.org/0000-0002-2455-5858"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory S. Karczmar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102009119","display_name":"Yan Chun Li","orcid":"https://orcid.org/0000-0001-9937-7630","observed_orcids":["https://orcid.org/0000-0001-9937-7630"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Chun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005112247","display_name":"Marc Bissonnette","orcid":"https://orcid.org/0000-0001-8420-4294","observed_orcids":["https://orcid.org/0000-0001-8420-4294"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Bissonnette","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.5605000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.5605000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.260699987411499,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0406000018119812,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renin-angiotensin-system","display_name":"renin-angiotensin system","score":0.9869999885559082},{"id":"https://openalex.org/keywords/egf-receptor","display_name":"EGF receptor","score":0.8880000114440918},{"id":"https://openalex.org/keywords/vitamin-d-receptor","display_name":"vitamin D receptor","score":1.0},{"id":"https://openalex.org/keywords/colitis-associated-cancer","display_name":"colitis-associated colorectal cancer","score":0.906000018119812},{"id":"https://openalex.org/keywords/colorectal-carcinogenesis","display_name":"colorectal carcinogenesis","score":0.8529999852180481},{"id":"https://openalex.org/keywords/angiotensin-ii","display_name":"angiotensin II","score":0.8389999866485596},{"id":"https://openalex.org/keywords/renin","display_name":"renin","score":0.8299999833106995},{"id":"https://openalex.org/keywords/snail1","display_name":"SNAI1","score":0.7020000219345093},{"id":"https://openalex.org/keywords/beta-catenin-signaling","display_name":"\u03b2-catenin signaling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.6150000095367432},{"id":"https://openalex.org/keywords/colonic-fibroblasts","display_name":"colonic fibroblasts","score":0.9079999923706055},{"id":"https://openalex.org/keywords/vitamin-d3","display_name":"vitamin D3","score":0.7440000176429749},{"id":"https://openalex.org/keywords/aom-dss-model","display_name":"AOM/DSS model","score":0.7689999938011169}],"concepts":[{"id":"https://openalex.org/C179639408","wikidata":"https://www.wikidata.org/wiki/Q417057","display_name":"Calcitriol receptor","level":3,"score":0.898558497428894},{"id":"https://openalex.org/C2778452354","wikidata":"https://www.wikidata.org/wiki/Q794084","display_name":"Azoxymethane","level":4,"score":0.7554899454116821},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6559296250343323},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6130304336547852},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5596141815185547},{"id":"https://openalex.org/C2908929049","wikidata":"https://www.wikidata.org/wiki/Q65963433","display_name":"Angiotensin II","level":3,"score":0.4757090210914612},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.4501769244670868},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.39177948236465454},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.37981027364730835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25819170475006104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18408715724945068},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.12455877661705017}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6523464","doi":"https://doi.org/10.1158/1078-0432.c.6523464","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6523464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6523464.v1","doi":"https://doi.org/10.1158/1078-0432.c.6523464.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6523464.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6523464","doi":"https://doi.org/10.1158/1078-0432.c.6523464","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6523464","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2159398047","https://openalex.org/W4362480632","https://openalex.org/W2055454357","https://openalex.org/W2946204885","https://openalex.org/W29991619","https://openalex.org/W2332346100","https://openalex.org/W2731782453","https://openalex.org/W2576870127","https://openalex.org/W2127800995","https://openalex.org/W4220701478"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"We":[2,44,83],"previously":[3],"showed":[4,190],"that":[5],"EGF":[6],"receptor":[7,25],"(EGFR)":[8],"promotes":[9],"tumorigenesis":[10],"in":[11,50,94,103,118,150,156,221,237],"the":[12,35,86,203],"azoxymethane/dextran":[13],"sulfate":[14],"sodium":[15],"(AOM/DSS)":[16],"model,":[17],"whereas":[18,39,214],"vitamin":[19,89],"D":[20,24,33],"suppresses":[21,202],"tumorigenesis.":[22],"EGFR\u2013vitamin":[23],"(VDR)":[26],"interactions,":[27,58],"however,":[28],"are":[29],"incompletely":[30],"understood.":[31],"Vitamin":[32],"inhibits":[34,211],"renin\u2013angiotensin":[36],"system":[37],"(RAS),":[38],"RAS":[40,71,93,134,205],"can":[41],"activate":[42],"EGFR.":[43],"aimed":[45],"to":[46],"elucidate":[47],"EGFR\u2013VDR":[48],"cross-talk":[49,236],"colorectal":[51],"carcinogenesis.":[52],"Experimental":[53],"Design:":[54],"To":[55],"examine":[56],"VDR\u2013RAS":[57],"we":[59],"treated":[60],"Vdr+/+":[61,95],"and":[62,72,80,107,128,131,138,162,177,197,210,218,234],"Vdr\u2212/\u2212":[63],"mice":[64,189],"with":[65,181],"AOM/DSS.":[66],"Effects":[67],"of":[68,88,99,195],"VDR":[69,100,201,220,235],"on":[70,91],"EGFR":[73,97,114,127,161,208,215,233],"were":[74],"examined":[75,85,102],"by":[76,168],"Western":[77],"blotting,":[78],"immunostaining,":[79],"real-time":[81],"PCR.":[82],"also":[84,174],"effect":[87],"D3":[90],"colonic":[92,133,145,178,204,222],"mice.":[96,109],"regulation":[98],"was":[101,116,148],"hypomorphic":[104],"EgfrWaved2":[105,184],"(Wa2)":[106],"Egfrwild-type":[108,188],"Angiotensin":[110],"II":[111,159,173],"(Ang":[112],"II)\u2013induced":[113],"activation":[115],"studied":[117],"cell":[119,166],"culture.":[120],"Results:Vdr":[121],"deletion":[122],"significantly":[123],"increased":[124,132,149],"tumorigenesis,":[125,213],"activated":[126,160,175],"\u03b2-catenin":[129],"signaling,":[130],"components,":[135],"including":[136],"renin":[137],"angiotensin":[139],"II.":[140],"Dietary":[141],"VD3":[142],"supplementation":[143],"suppressed":[144],"renin.":[146],"Renin":[147],"human":[151],"colon":[152,164,238],"cancers.":[153],"In":[154],"studies":[155],"vitro,":[157],"Ang":[158,172],"stimulated":[163],"cancer":[165],"proliferation":[167],"an":[169],"EGFR-mediated":[170],"mechanism.":[171],"macrophages":[176],"fibroblasts.":[179],"Compared":[180],"tumors":[182,186],"from":[183,187],"mice,":[185],"upregulated":[191],"Snail1,":[192],"a":[193,229],"suppressor":[194],"VDR,":[196],"downregulated":[198],"VDR.":[199],"Conclusions:":[200],"cascade,":[206],"limits":[207],"signals,":[209],"colitis-associated":[212],"increases":[216],"Snail1":[217],"downregulates":[219],"tumors.":[223],"Taken":[224],"together,":[225],"these":[226],"results":[227],"uncover":[228],"RAS-dependent":[230],"mechanism":[231],"mediating":[232],"cancer.":[239],"Clin":[240],"Cancer":[241],"Res;":[242],"20(22);":[243],"5848\u201359.":[244],"\u00a92014":[245],"AACR.":[246]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
