{"id":"https://openalex.org/W4361945589","doi":"https://doi.org/10.1158/1078-0432.c.6525201","title":"Data from The Genomic Landscape of Male Breast Cancers","display_name":"Data from The Genomic Landscape of Male Breast Cancers","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361945589","doi":"https://doi.org/10.1158/1078-0432.c.6525201"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6525201","doi":"https://doi.org/10.1158/1078-0432.c.6525201","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525201","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6525201","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051087530","display_name":"Salvatore Piscuoglio","orcid":"https://orcid.org/0000-0003-2686-2939","observed_orcids":["https://orcid.org/0000-0003-2686-2939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Salvatore Piscuoglio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057848295","display_name":"Charlotte K.Y. Ng","orcid":"https://orcid.org/0000-0002-6100-0026","observed_orcids":["https://orcid.org/0000-0002-6100-0026"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlotte K.Y. Ng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031683228","display_name":"Melissa P. Murray","orcid":"https://orcid.org/0000-0002-2935-6014","observed_orcids":["https://orcid.org/0000-0002-2935-6014"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melissa P. Murray","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017749409","display_name":"Elena Guerini\u2010Rocco","orcid":"https://orcid.org/0000-0003-2001-7582","observed_orcids":["https://orcid.org/0000-0003-2001-7582"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elena Guerini-Rocco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023182871","display_name":"Luciano Gast\u00f3n Martelotto","orcid":"https://orcid.org/0000-0002-9625-1183","observed_orcids":["https://orcid.org/0000-0002-9625-1183"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luciano G. Martelotto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103035323","display_name":"Felipe Correa Geyer","orcid":"https://orcid.org/0000-0002-9978-6650","observed_orcids":["https://orcid.org/0000-0002-9978-6650","https://orcid.org/0000-0002-9625-2346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Felipe C. Geyer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005286764","display_name":"Fran\u00e7ois\u2010Cl\u00e9ment Bidard","orcid":"https://orcid.org/0000-0001-5932-8949","observed_orcids":["https://orcid.org/0000-0001-5932-8949"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francois-Clement Bidard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016638133","display_name":"Samuel Berman","orcid":"https://orcid.org/0000-0002-4321-387X","observed_orcids":["https://orcid.org/0000-0002-4321-387X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samuel Berman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029040081","display_name":"Nicola Fusco","orcid":"https://orcid.org/0000-0002-9101-9131","observed_orcids":["https://orcid.org/0000-0002-9101-9131"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicola Fusco","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103221229","display_name":"Rita A. Sakr","orcid":"https://orcid.org/0009-0001-9846-7228","observed_orcids":["https://orcid.org/0009-0001-9846-7228"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rita A. Sakr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007310378","display_name":"Carey A. Eberle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carey A. Eberle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086060519","display_name":"Leticia De Mattos\u2010Arruda","orcid":"https://orcid.org/0000-0002-4992-3645","observed_orcids":["https://orcid.org/0000-0002-4992-3645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leticia De Mattos-Arruda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089906802","display_name":"Gabriel S. Macedo","orcid":"https://orcid.org/0000-0002-8963-9577","observed_orcids":["https://orcid.org/0000-0002-8963-9577"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel S. Macedo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113495422","display_name":"Muzaffar M. Akram","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Muzaffar Akram","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001561973","display_name":"Timour Baslan","orcid":"https://orcid.org/0009-0008-2632-0586","observed_orcids":["https://orcid.org/0009-0008-2632-0586","https://orcid.org/0000-0001-5674-6432"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timour Baslan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025053302","display_name":"James B Hicks","orcid":"https://orcid.org/0000-0001-5353-4338","observed_orcids":["https://orcid.org/0000-0001-5353-4338"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James B. Hicks","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076310424","display_name":"Tari A. King","orcid":"https://orcid.org/0000-0003-3602-2351","observed_orcids":["https://orcid.org/0000-0003-3602-2351"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tari A. King","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080183722","display_name":"Edi Brogi","orcid":"https://orcid.org/0000-0003-4737-8468","observed_orcids":["https://orcid.org/0000-0003-4737-8468"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Edi Brogi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039225060","display_name":"Larry Norton","orcid":"https://orcid.org/0000-0003-3701-9250","observed_orcids":["https://orcid.org/0000-0003-3701-9250"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larry Norton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040506127","display_name":"Britta Weigelt","orcid":"https://orcid.org/0000-0001-9927-1270","observed_orcids":["https://orcid.org/0000-0001-9927-1270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Britta Weigelt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047713528","display_name":"Clifford A. Hudis","orcid":"https://orcid.org/0000-0001-7144-8791","observed_orcids":["https://orcid.org/0000-0001-7144-8791"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clifford A. Hudis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5077235697","display_name":"Jorge Sergio Reis-Filho","orcid":"https://orcid.org/0000-0003-2969-3173","observed_orcids":["https://orcid.org/0000-0003-2969-3173"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jorge S. Reis-Filho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13097","display_name":"Male Breast Health Studies","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13097","display_name":"Male Breast Health Studies","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.010700000450015068,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/male-breast-cancer","display_name":"male breast cancer","score":1.0},{"id":"https://openalex.org/keywords/genomic-landscape","display_name":"genomic landscape","score":0.6919999718666077},{"id":"https://openalex.org/keywords/somatic-mutations","display_name":"somatic mutations","score":0.9829999804496765},{"id":"https://openalex.org/keywords/copy-number-alterations","display_name":"copy number alterations","score":0.9810000061988831},{"id":"https://openalex.org/keywords/estrogen-receptor-positive-breast-cancer","display_name":"estrogen receptor-positive breast cancer","score":0.7739999890327454},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.9739999771118164},{"id":"https://openalex.org/keywords/pik3ca-mutation","display_name":"PIK3CA mutation","score":0.8109999895095825},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/16q-loss","display_name":"16q loss","score":0.9520000219345093},{"id":"https://openalex.org/keywords/gata3","display_name":"GATA3","score":0.8429999947547913},{"id":"https://openalex.org/keywords/dna-repair-genes","display_name":"DNA repair genes","score":0.9129999876022339},{"id":"https://openalex.org/keywords/cancer-subtyping","display_name":"cancer subtyping","score":0.5609999895095825}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7387040257453918},{"id":"https://openalex.org/C102037460","wikidata":"https://www.wikidata.org/wiki/Q18025464","display_name":"GATA3","level":4,"score":0.7228624224662781},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.5644940137863159},{"id":"https://openalex.org/C2777396416","wikidata":"https://www.wikidata.org/wiki/Q6742919","display_name":"Male breast cancer","level":4,"score":0.5296226143836975},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4709143340587616},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44639524817466736},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.44031038880348206},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4393611252307892},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.42961984872817993},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41718152165412903},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.41288843750953674},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3743063509464264},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2770739793777466},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1243806779384613},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.12249940633773804}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6525201","doi":"https://doi.org/10.1158/1078-0432.c.6525201","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525201","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6525201.v1","doi":"https://doi.org/10.1158/1078-0432.c.6525201.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6525201.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6525201","doi":"https://doi.org/10.1158/1078-0432.c.6525201","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525201","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2421692008","https://openalex.org/W3005649145","https://openalex.org/W1572676399","https://openalex.org/W2963966788","https://openalex.org/W3169778338","https://openalex.org/W4400955848","https://openalex.org/W2005787512","https://openalex.org/W2526743348","https://openalex.org/W2059079705","https://openalex.org/W3010523936"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Male":[2,146,217],"breast":[3,25,34,42,54,60,73,100,116,125,134,147,168,181,197,202,218,230,250,281,285],"cancer":[4,26],"is":[5,27],"rare,":[6],"and":[7,65,79,84,110,130,176,189,191,235,238,274],"its":[8],"genomic":[9,263],"landscape":[10],"has":[11],"yet":[12],"to":[13,38,86,158,206,283],"be":[14,207,267],"fully":[15],"characterized.":[16],"Lacking":[17],"studies":[18,278],"in":[19,31,48,52,98,269],"men,":[20],"treatment":[21],"of":[22,93,107,114,122,132,153,163,227,240,248,258,272,279],"males":[23],"with":[24,33,120],"extrapolated":[28],"from":[29,277],"results":[30],"females":[32],"cancer.":[35],"We":[36],"sought":[37],"define":[39],"whether":[40],"male":[41,59,72,115,133,180,201,249,284],"cancers":[43,61,74,101,117,135,148,203,219,251,282],"harbor":[44,222],"somatic":[45,108,154,223,259],"genetic":[46,155,224],"alterations":[47,113,156,225],"genes":[49,95],"frequently":[50,96,185,221],"altered":[51],"female":[53,99,124,167,196,229,280],"cancers.":[55,126,198,286],"Experimental":[56],"Design:":[57],"All":[58],"were":[62,69,75,82,118,136,204],"estrogen":[63,164],"receptor\u2013positive,":[64],"all":[66,91],"but":[67],"two":[68],"HER2-negative.":[70],"Fifty-nine":[71],"subtyped":[76],"by":[77,254],"immunohistochemistry,":[78],"tumor\u2013normal":[80],"pairs":[81],"microdissected":[83],"subjected":[85],"massively":[87],"parallel":[88],"sequencing":[89],"targeting":[90],"exons":[92],"241":[94],"mutated":[97],"or":[102,142],"DNA-repair":[103],"related.":[104],"The":[105],"repertoires":[106],"mutations":[109,172,193,211,237],"copy":[111],"number":[112],"compared":[119],"that":[121,157,162,243],"subtype-matched":[123],"Results:":[127],"Twenty-nine":[128],"percent":[129],"71%":[131],"immunohistochemically":[137],"classified":[138],"as":[139,233],"luminal":[140,143],"A\u2013like":[141],"B\u2013like,":[144],"respectively.":[145],"displayed":[149],"a":[150,246,255],"heterogeneous":[151],"repertoire":[152,257],"some":[159],"extent":[160],"recapitulated":[161],"receptor":[165],"(ER)-positive/HER2-negative":[166],"cancers,":[169,182,231],"including":[170],"recurrent":[171],"affecting":[173,212],"PIK3CA":[174,190,234],"(20%)":[175],"GATA3":[177],"(15%).":[178],"ER-positive/HER2-negative":[179,195,228],"however,":[183],"less":[184,220],"harbored":[186],"16q":[187],"losses,":[188],"TP53":[192,236],"than":[194],"In":[199],"addition,":[200],"found":[205],"significantly":[208],"enriched":[209],"for":[210],"DNA":[213],"repair\u2013related":[214],"genes.":[215],"Conclusions:":[216],"typical":[226],"such":[232],"losses":[239],"16q,":[241],"suggesting":[242],"at":[244],"least":[245],"subset":[247],"are":[252],"driven":[253],"distinct":[256],"changes.":[260],"Given":[261],"the":[262,270],"differences,":[264],"caution":[265],"may":[266],"needed":[268],"application":[271],"biologic":[273],"therapeutic":[275],"findings":[276],"Clin":[287],"Cancer":[288],"Res;":[289],"22(16);":[290],"4045\u201356.":[291],"\u00a92016":[292],"AACR.":[293]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}