{"id":"https://openalex.org/W4361945375","doi":"https://doi.org/10.1158/1078-0432.c.6525212","title":"Data from Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations","display_name":"Data from Clinical Features and Outcomes of Patients with Colorectal Cancers Harboring NRAS Mutations","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361945375","doi":"https://doi.org/10.1158/1078-0432.c.6525212"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6525212","doi":"https://doi.org/10.1158/1078-0432.c.6525212","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6525212","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6525212","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031539570","display_name":"Andrea Cercek","orcid":"https://orcid.org/0000-0002-5054-8192","observed_orcids":["https://orcid.org/0000-0002-5054-8192"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrea Cercek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075080955","display_name":"Maria Ignez Braghiroli","orcid":"https://orcid.org/0000-0001-6366-8786","observed_orcids":["https://orcid.org/0000-0001-6366-8786"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Ignez Braghiroli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038396374","display_name":"Joanne F. Chou","orcid":"https://orcid.org/0000-0002-6866-2022","observed_orcids":["https://orcid.org/0000-0002-6866-2022"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanne F. Chou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031045426","display_name":"Jaclyn Frances Hechtman","orcid":"https://orcid.org/0000-0003-2645-0985","observed_orcids":["https://orcid.org/0000-0003-2645-0985"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaclyn F. Hechtman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069644669","display_name":"Nancy E. Kemeny","orcid":"https://orcid.org/0000-0002-0929-9542","observed_orcids":["https://orcid.org/0000-0002-0929-9542"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nancy Kemeny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037120205","display_name":"Leonard B. Saltz","orcid":"https://orcid.org/0000-0001-8353-4670","observed_orcids":["https://orcid.org/0000-0001-8353-4670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leonard Saltz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045756365","display_name":"Marinela Capanu","orcid":"https://orcid.org/0000-0003-4953-3193","observed_orcids":["https://orcid.org/0000-0003-4953-3193"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marinela Capanu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5038339239","display_name":"Rona D. Yaeger","orcid":"https://orcid.org/0000-0002-7233-5454","observed_orcids":["https://orcid.org/0000-0002-7233-5454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rona Yaeger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10335","display_name":"Colorectal Cancer Surgical Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nras-mutation","display_name":"NRAS mutation","score":0.9020000100135803},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/ras-mutations","display_name":"RAS mutations","score":0.671999990940094},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6700000166893005},{"id":"https://openalex.org/keywords/african-american-patients","display_name":"African American patients","score":0.9419999718666077},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.4129999876022339},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6370000243186951},{"id":"https://openalex.org/keywords/resection-rate","display_name":"resection rate","score":0.6430000066757202}],"concepts":[{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.9168068766593933},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8679955005645752},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6106249094009399},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5668663382530212},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39643871784210205},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3254305422306061},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.32085394859313965}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6525212","doi":"https://doi.org/10.1158/1078-0432.c.6525212","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6525212","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6525212.v1","doi":"https://doi.org/10.1158/1078-0432.c.6525212.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6525212.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6525212","doi":"https://doi.org/10.1158/1078-0432.c.6525212","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6525212","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2609352512","https://openalex.org/W2587975283","https://openalex.org/W2890483384","https://openalex.org/W2597380560","https://openalex.org/W1538989751","https://openalex.org/W3012554172","https://openalex.org/W2471864605","https://openalex.org/W4415378964","https://openalex.org/W2308033649","https://openalex.org/W2164523473"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"NRAS":[2,25,70,120,135,195,206,220,234],"mutations":[3,71,221],"are":[4,35,222,235],"now":[5],"routinely":[6],"included":[7],"in":[8,224,233],"RAS":[9,86,152,178],"testing":[10],"prior":[11],"to":[12,31,42,80,96],"EGFR":[13],"inhibitor":[14],"therapy":[15],"for":[16,65,147,151,168,172,177,189,194,199],"metastatic":[17],"colorectal":[18],"cancer":[19],"(mCRC).":[20],"The":[21],"clinical":[22,45,59,213],"implications":[23],"of":[24,29,50,85,102,161,192],"mutation":[26,136,196,201],"beyond":[27],"lack":[28],"response":[30],"anti-EGFR":[32],"therapy,":[33],"however,":[34],"not":[36],"known.":[37],"We":[38,57],"undertook":[39],"this":[40],"study":[41],"determine":[43],"the":[44],"features":[46],"and":[47,63,88,111,121,127,174,197,217,228,240],"treatment":[48],"outcomes":[49,64,242],"patients":[51,104],"with":[52,69,118,134,211,237],"NRAS-mutant":[53,106,148],"mCRC.":[54,156,219,248],"Experimental":[55],"Design:":[56],"reviewed":[58],"characteristics,":[60],"concurrent":[61,119],"mutations,":[62],"all":[66],"mCRC":[67,90,103,149],"cases":[68,92,117,180],"undergoing":[72],"standard":[73],"genotyping":[74],"at":[75,142],"our":[76],"institution":[77],"from":[78,94,159,215],"2008":[79,95],"2015.":[81],"Comparison":[82],"groups":[83],"consisted":[84],"wild-type":[87,153,179,218,247],"KRAS-mutant":[89,155,216,245],"consecutive":[91],"genotyped":[93],"2012.":[97],"Results:":[98],"Three":[99],"percent":[100],"(87/2764)":[101],"had":[105],"tumors":[107,227],"(45%":[108],"exon":[109,113],"2":[110],"55%":[112],"3),":[114],"including":[115],"three":[116],"KRAS":[122,200],"mutations.":[123],"Left-sided":[124],"primary":[125,226],"site":[126],"African":[128,230],"American":[129],"self-reported":[130],"race":[131],"were":[132],"associated":[133,236],"(P":[137,181,202],"<":[138,182,203],"0.01).":[139,204],"Resection":[140],"rate":[141],"12":[143],"months":[144,167,171,176],"was":[145,165],"lower":[146],"than":[150,243],"or":[154,246],"Median":[157],"survival":[158,191,239],"time":[160],"first":[162],"known":[163],"metastasis":[164],"33":[166],"NRAS-mutant,":[169],"47":[170],"KRAS-mutant,":[173],"78":[175],"0.001).":[183],"Multivariate":[184],"analysis":[185],"assigned":[186],"an":[187],"HR":[188],"overall":[190],"2.0":[193],"1.5":[198],"Conclusions:":[205],"defines":[207],"a":[208],"molecular":[209],"subset":[210],"distinct":[212],"characteristics":[214],"enriched":[223],"left-sided":[225],"among":[229],"Americans.":[231],"Mutations":[232],"poor":[238],"worse":[241],"either":[244],"Clin":[249],"Cancer":[250],"Res;":[251],"23(16);":[252],"4753\u201360.":[253],"\u00a92017":[254],"AACR.":[255]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
