{"id":"https://openalex.org/W4361945319","doi":"https://doi.org/10.1158/1078-0432.c.6525020","title":"Data from Inactivation of Receptor Tyrosine Kinases Reverts Aberrant DNA Methylation in Acute Myeloid Leukemia","display_name":"Data from Inactivation of Receptor Tyrosine Kinases Reverts Aberrant DNA Methylation in Acute Myeloid Leukemia","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361945319","doi":"https://doi.org/10.1158/1078-0432.c.6525020"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6525020","doi":"https://doi.org/10.1158/1078-0432.c.6525020","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525020","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6525020","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037219613","display_name":"Na Shen","orcid":"https://orcid.org/0000-0003-4362-9207","observed_orcids":["https://orcid.org/0000-0003-4362-9207"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Na Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Fei Yan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fei Yan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104033675","display_name":"Jiuxia Pang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiuxia Pang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102016730","display_name":"Na Zhao","orcid":"https://orcid.org/0000-0002-7755-3637","observed_orcids":["https://orcid.org/0000-0002-7755-3637"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Na Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002643270","display_name":"Naseema Gangat","orcid":"https://orcid.org/0000-0002-9104-6172","observed_orcids":["https://orcid.org/0000-0002-9104-6172"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naseema Gangat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052947767","display_name":"Lai\u2010Chu Wu","orcid":"https://orcid.org/0000-0002-1348-269X","observed_orcids":["https://orcid.org/0000-0002-1348-269X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laichu Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051769949","display_name":"Ann M. Bode","orcid":"https://orcid.org/0000-0002-7432-082X","observed_orcids":["https://orcid.org/0000-0002-7432-082X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ann M. Bode","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008422091","display_name":"Aref Al\u2010Kali","orcid":"https://orcid.org/0000-0002-0824-3715","observed_orcids":["https://orcid.org/0000-0002-0824-3715"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aref Al-Kali","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085360755","display_name":"Mark Robert Litzow","orcid":"https://orcid.org/0000-0002-9816-6302","observed_orcids":["https://orcid.org/0000-0002-9816-6302"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark R. Litzow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5100726824","display_name":"Shujun Liu","orcid":"https://orcid.org/0009-0001-6754-2440","observed_orcids":["https://orcid.org/0009-0001-6754-2440"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shujun Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9096999764442444,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.08269999921321869,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/receptor-tyrosine-kinases","display_name":"receptor tyrosine kinase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.9279999732971191},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8820000290870667},{"id":"https://openalex.org/keywords/dna-methyltransferases","display_name":"DNA methyltransferases","score":0.9070000052452087},{"id":"https://openalex.org/keywords/nilotinib","display_name":"nilotinib","score":0.9279999732971191},{"id":"https://openalex.org/keywords/receptor-tyrosine-kinase-inhibitors","display_name":"receptor tyrosine kinase inhibitors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/dnmt1","display_name":"DNMT1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/sp1","display_name":"Sp1","score":0.8209999799728394},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.9890000224113464},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.8119999766349792},{"id":"https://openalex.org/keywords/epigenetic-reprogramming","display_name":"epigenetic reprogramming","score":0.7120000123977661},{"id":"https://openalex.org/keywords/pharmacodynamic-markers","display_name":"pharmacodynamic biomarkers","score":0.7369999885559082},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6570000052452087},{"id":"https://openalex.org/keywords/clonogenicity","display_name":"clonogenicity","score":0.7670000195503235}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7340160608291626},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6565163135528564},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.5822011232376099},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.5743435025215149},{"id":"https://openalex.org/C91965660","wikidata":"https://www.wikidata.org/wiki/Q415875","display_name":"Methyltransferase","level":4,"score":0.5738545060157776},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.491356760263443},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.49036502838134766},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.487930029630661},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.48612260818481445},{"id":"https://openalex.org/C175211621","wikidata":"https://www.wikidata.org/wiki/Q14907998","display_name":"DNMT1","level":5,"score":0.4625036418437958},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.4557676911354065},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.43724897503852844},{"id":"https://openalex.org/C2779979206","wikidata":"https://www.wikidata.org/wiki/Q1154602","display_name":"DNA methyltransferase","level":5,"score":0.42295217514038086},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3387371301651001},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.23751258850097656},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.20903745293617249},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.19781723618507385},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16862794756889343},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12628930807113647},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1079966127872467},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6525020","doi":"https://doi.org/10.1158/1078-0432.c.6525020","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525020","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6525020.v1","doi":"https://doi.org/10.1158/1078-0432.c.6525020.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6525020.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6525020","doi":"https://doi.org/10.1158/1078-0432.c.6525020","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6525020","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2739363814","https://openalex.org/W2212324737","https://openalex.org/W1813888483","https://openalex.org/W2980209802","https://openalex.org/W2585524437","https://openalex.org/W4312948438","https://openalex.org/W2984504463","https://openalex.org/W2041690843","https://openalex.org/W1525486670","https://openalex.org/W2352697229"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Receptor":[2],"tyrosine":[3],"kinases":[4],"(RTKs)":[5],"are":[6,29],"frequently":[7],"deregulated":[8],"in":[9,40,87,91,94,107,134,157,180,186,223,243,247],"leukemia,":[10,28],"yet":[11],"the":[12,36,45,129,141,148,151],"biological":[13],"consequences":[14],"of":[15,27,38,48,59,82,84,102,115,137,143,150,168,174,195,214],"this":[16],"deregulation":[17],"remain":[18],"elusive.":[19],"The":[20,77],"mechanisms":[21,81],"underlying":[22],"aberrant":[23],"methylation,":[24,146],"a":[25,135,227],"hallmark":[26],"not":[30],"fully":[31],"understood.":[32],"Here":[33],"we":[34],"investigated":[35],"role":[37],"RTKs":[39,56,103,116,210],"methylation":[41,74,217,221],"abnormalities":[42,246],"and":[43,54,71,80,93,111,124,147,161,172,188,203,218],"characterized":[44],"hypomethylating":[46],"activities":[47,79],"RTK":[49,85,130,241],"inhibitors.":[50],"Experimental":[51],"Design:":[52],"Whether":[53],"how":[55],"regulate":[57],"expression":[58,120,123,194],"DNA":[60,73,125,145,199,216,220],"methyltransferases":[61],"(DNMTs),":[62],"tumor":[63],"suppressor":[64],"genes":[65],"(TSGs)":[66],"as":[67,69,211,226],"well":[68],"global":[70,144],"gene-specific":[72],"were":[75,98],"examined.":[76],"pharmacologic":[78],"actions":[83],"inhibitors":[86,242],"vitro,":[88],"ex":[89],"vivo,":[90],"mice,":[92],"nilotinib-treated":[95],"leukemia":[96,108,204],"patients":[97,190],"determined.":[99],"Results:":[100],"Upregulation":[101],"paralleled":[104],"DNMT":[105,122],"overexpression":[106],"cell":[109,159,170,181],"lines":[110,160],"patient":[112,162],"blasts.":[113,163],"Knockdown":[114],"disrupted,":[117],"whereas":[118],"enforced":[119],"increased":[121],"methylation.":[126],"Treatment":[127],"with":[128,191],"inhibitor,":[131],"nilotinib,":[132],"resulted":[133],"reduction":[136],"Sp1-dependent":[138],"DNMT1":[139],"expression,":[140],"diminution":[142],"upregulation":[149],"p15INK4B":[152],"gene":[153],"through":[154],"promoter":[155],"hypomethylation":[156],"AML":[158,169,192,224],"This":[164],"led":[165],"to":[166,233],"disruption":[167],"clonogenicity":[171],"promotion":[173],"cellular":[175],"apoptosis":[176],"without":[177],"obvious":[178],"changes":[179],"cycle.":[182],"Importantly,":[183],"nilotinib":[184],"administration":[185],"mice":[187],"human":[189],"impaired":[193],"DNMTs":[196],"followed":[197],"by":[198],"hypomethylation,":[200],"TSG":[201],"re-expression,":[202],"regression.":[205],"Conclusions:":[206],"Our":[207],"findings":[208],"demonstrate":[209],"novel":[212],"regulators":[213],"DNMT-dependent":[215],"define":[219],"status":[222],"cells":[225],"pharmacodynamic":[228],"marker":[229],"for":[230,240],"their":[231],"response":[232],"RTK-based":[234],"therapy,":[235],"providing":[236],"new":[237],"therapeutic":[238],"avenues":[239],"overcoming":[244],"epigenetic":[245],"leukemia.":[248],"Clin":[249],"Cancer":[250],"Res;":[251],"23(20);":[252],"6254\u201366.":[253],"\u00a92017":[254],"AACR.":[255]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
