{"id":"https://openalex.org/W4361945282","doi":"https://doi.org/10.1158/1078-0432.c.6524201","title":"Data from The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer","display_name":"Data from The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361945282","doi":"https://doi.org/10.1158/1078-0432.c.6524201"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6524201","doi":"https://doi.org/10.1158/1078-0432.c.6524201","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6524201","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6524201","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100569907","display_name":"Shumei Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shumei Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026564012","display_name":"Soichiro Honjo","orcid":"https://orcid.org/0000-0001-9319-1974","observed_orcids":["https://orcid.org/0000-0001-9319-1974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soichiro Honjo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084410596","display_name":"Jiankang Jin","orcid":"https://orcid.org/0000-0001-9864-9817","observed_orcids":["https://orcid.org/0000-0001-9864-9817"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jiankang Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110488","display_name":"Shih-Shin Chang","orcid":"https://orcid.org/0009-0005-1652-9261","observed_orcids":["https://orcid.org/0009-0005-1652-9261"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shih-Shin Chang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033556493","display_name":"Ailing W. Scott","orcid":"https://orcid.org/0009-0005-1473-1116","observed_orcids":["https://orcid.org/0009-0005-1473-1116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ailing W. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043074358","display_name":"Qiongrong Chen","orcid":"https://orcid.org/0000-0002-6613-535X","observed_orcids":["https://orcid.org/0000-0002-6613-535X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiongrong Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103148045","display_name":"Neda Kalhor","orcid":"https://orcid.org/0000-0001-6891-6435","observed_orcids":["https://orcid.org/0000-0001-6891-6435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neda Kalhor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113490107","display_name":"Arlene M. Correa","orcid":"https://orcid.org/0009-0001-8495-6602","observed_orcids":["https://orcid.org/0009-0001-8495-6602"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arlene M. Correa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112255361","display_name":"Wayne Lewis Hofstetter","orcid":"https://orcid.org/0000-0002-4865-2783","observed_orcids":["https://orcid.org/0000-0002-4865-2783"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wayne L. Hofstetter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035866819","display_name":"Constance T. Albarracin","orcid":"https://orcid.org/0000-0002-1236-7315","observed_orcids":["https://orcid.org/0000-0002-1236-7315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Constance T. Albarracin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082265798","display_name":"Tsung\u2010Teh Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tsung-Teh Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069957994","display_name":"Randy L. Johnson","orcid":"https://orcid.org/0000-0003-4549-3593","observed_orcids":["https://orcid.org/0000-0003-4549-3593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Randy L. Johnson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076834432","display_name":"Mien\u2010Chie Hung","orcid":"https://orcid.org/0000-0003-4317-4740","observed_orcids":["https://orcid.org/0000-0003-4317-4740"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mien-Chie Hung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5044064524","display_name":"Jaffer A. Ajani","orcid":"https://orcid.org/0000-0001-9946-0629","observed_orcids":["https://orcid.org/0000-0001-9946-0629"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaffer A. Ajani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":0.996999979019165},{"id":"https://openalex.org/keywords/egfr-overexpression","display_name":"EGFR overexpression","score":0.9269999861717224},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.9850000143051147},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hippo-signaling-pathway","display_name":"Hippo signaling pathway","score":0.8700000047683716},{"id":"https://openalex.org/keywords/5-fluorouracil-resistance","display_name":"5-fluorouracil resistance","score":0.9520000219345093},{"id":"https://openalex.org/keywords/docetaxel-resistance","display_name":"docetaxel resistance","score":0.9959999918937683},{"id":"https://openalex.org/keywords/verteporfin","display_name":"verteporfin","score":0.996999979019165},{"id":"https://openalex.org/keywords/egfr-inhibitors","display_name":"EGFR inhibitors","score":0.8119999766349792}],"concepts":[{"id":"https://openalex.org/C2780219982","wikidata":"https://www.wikidata.org/wiki/Q17544238","display_name":"YAP1","level":4,"score":0.8727849125862122},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7388947010040283},{"id":"https://openalex.org/C2779742542","wikidata":"https://www.wikidata.org/wiki/Q372701","display_name":"Esophageal cancer","level":3,"score":0.6972969770431519},{"id":"https://openalex.org/C172512520","wikidata":"https://www.wikidata.org/wiki/Q5768379","display_name":"Hippo signaling pathway","level":3,"score":0.6344665288925171},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5261164307594299},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.48318997025489807},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3975464105606079},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39567679166793823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3610432744026184},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34241199493408203},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.21366018056869507},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20070266723632812},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.1917724907398224},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.0915437638759613},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.058173924684524536},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6524201","doi":"https://doi.org/10.1158/1078-0432.c.6524201","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6524201","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6524201","doi":"https://doi.org/10.1158/1078-0432.c.6524201","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6524201","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2160004726","https://openalex.org/W2767357157","https://openalex.org/W3210868329","https://openalex.org/W2807924383","https://openalex.org/W4319592465","https://openalex.org/W4385955473","https://openalex.org/W2341829316","https://openalex.org/W4361947003","https://openalex.org/W2904088419","https://openalex.org/W2740779654"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Esophageal":[2],"cancer":[3,139,145,187,228],"is":[4],"an":[5,161,219],"aggressive":[6],"malignancy":[7],"and":[8,63,86,89,102,104,124,132,179,200,203],"often":[9],"resistant":[10,137],"to":[11,49,96,177,189,206],"therapy.":[12],"Overexpression":[13],"of":[14,22,43,61,158,173,183,216],"EGFR":[15,31,44,64,100,122,133,153,167,201,217,239],"has":[16],"been":[17],"associated":[18],"with":[19,24,39,51,107,142],"poor":[20],"prognosis":[21],"patients":[23,38],"esophageal":[25,40,110,138,144,186,227,242],"cancer.":[26,41,111,243],"However,":[27],"clinical":[28],"trials":[29],"using":[30],"inhibitors":[32],"have":[33],"not":[34],"provided":[35],"benefit":[36],"for":[37],"Failure":[42],"inhibition":[45],"may":[46,233],"be":[47,234],"due":[48],"crosstalk":[50],"other":[52],"oncogenic":[53],"pathways.":[54],"Experimental":[55],"Design:":[56],"In":[57],"this":[58],"study,":[59],"expression":[60,101,123,154,202],"YAP1":[62,119,131,151,174,184,194,199,214],"were":[65,94],"examined":[66],"in":[67,87,90,109,126,136,165,222,226,241],"EAC-resistant":[68],"tumor":[69],"tissues":[70,73,140],"versus":[71],"sensitive":[72,143],"by":[74],"IHC.":[75],"Western":[76],"blot":[77],"analysis,":[78,83],"immunofluorescence,":[79],"real-time":[80],"PCR,":[81],"promoter":[82],"site-directed":[84],"mutagenesis,":[85],"vitro":[88],"vivo":[91],"functional":[92],"assays":[93],"performed":[95],"elucidate":[97],"the":[98,105,156,166],"YAP1-mediated":[99],"transcription":[103,125,159],"relationship":[106],"chemoresistance":[108],"Results:":[112],"We":[113],"demonstrate":[114],"that":[115,150,213],"Hippo":[116],"pathway":[117],"coactivator":[118],"can":[120],"induce":[121],"multiple":[127],"cell":[128],"systems.":[129],"Both":[130],"are":[134],"overexpressed":[135],"compared":[141],"tissues.":[146],"Furthermore,":[147],"we":[148],"found":[149],"increases":[152],"at":[155],"level":[157],"requiring":[160],"intact":[162],"TEAD-binding":[163],"site":[164],"promoter.":[168],"Most":[169],"importantly,":[170],"exogenous":[171],"induction":[172],"induces":[175],"resistance":[176,225],"5-fluorouracil":[178],"docetaxcel,":[180],"whereas":[181],"knockdown":[182],"sensitizes":[185,204],"cells":[188,205],"these":[190],"cytotoxics.":[191,207],"Verteporfin,":[192],"a":[193],"inhibitor,":[195],"effectively":[196],"inhibits":[197],"both":[198],"Conclusions:":[208],"Our":[209],"data":[210],"provide":[211],"evidence":[212],"upregulation":[215],"plays":[218],"important":[220],"role":[221],"conferring":[223],"therapy":[224],"cells.":[229],"Targeting":[230],"YAP1-EGFR":[231],"axis":[232],"more":[235],"efficacious":[236],"than":[237],"targeting":[238],"alone":[240],"Clin":[244],"Cancer":[245],"Res;":[246],"21(11);":[247],"2580\u201390.":[248],"\u00a92015":[249],"AACR.":[250]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}