{"id":"https://openalex.org/W4361945217","doi":"https://doi.org/10.1158/1078-0432.c.6523203","title":"Data from The Novel IKK2 Inhibitor LY2409881 Potently Synergizes with Histone Deacetylase Inhibitors in Preclinical Models of Lymphoma through the Downregulation of NF-\u03baB","display_name":"Data from The Novel IKK2 Inhibitor LY2409881 Potently Synergizes with Histone Deacetylase Inhibitors in Preclinical Models of Lymphoma through the Downregulation of NF-\u03baB","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361945217","doi":"https://doi.org/10.1158/1078-0432.c.6523203"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6523203","doi":"https://doi.org/10.1158/1078-0432.c.6523203","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6523203","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6523203","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101491956","display_name":"Changchun Deng","orcid":"https://orcid.org/0000-0001-9372-6086","observed_orcids":["https://orcid.org/0000-0001-9372-6086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changchun Deng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057939557","display_name":"Mark R. Lipstein","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Lipstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Richard Rodriguez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Rodriguez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071807274","display_name":"Xavier O. Jirau Serrano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xavier O. Jirau Serrano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084019868","display_name":"Christine M. Mcintosh","orcid":"https://orcid.org/0000-0003-3401-8914","observed_orcids":["https://orcid.org/0000-0003-3401-8914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine McIntosh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014482412","display_name":"Wei\u2010Yann Tsai","orcid":"https://orcid.org/0000-0002-5832-1400","observed_orcids":["https://orcid.org/0000-0002-5832-1400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wei-Yann Tsai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021806378","display_name":"Andrew S. Wasmuth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew S. Wasmuth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049236815","display_name":"Susan Jaken","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan Jaken","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5002126535","display_name":"Owen A. O\u2019Connor","orcid":"https://orcid.org/0000-0002-5631-0011","observed_orcids":["https://orcid.org/0000-0002-5631-0011"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Owen A. O'Connor","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9229000210762024,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.06790000200271606,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ikappab-kinase-beta","display_name":"I\u03baB kinase \u03b2","score":0.8659999966621399},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8500000238418579},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.9639999866485596},{"id":"https://openalex.org/keywords/romidepsin","display_name":"romidepsin","score":1.0},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6919999718666077},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.9190000295639038},{"id":"https://openalex.org/keywords/t-cell-lymphoma","display_name":"T-cell lymphoma","score":0.9319999814033508},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6029999852180481},{"id":"https://openalex.org/keywords/nf-kappab-p65","display_name":"NF-\u03baB p65","score":0.7979999780654907},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/xenograft-tumor-model","display_name":"xenograft tumor model","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5785784125328064},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5710848569869995},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5430348515510559},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.4847221374511719},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.478074312210083},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4771925210952759},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.4722810685634613},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4700454771518707},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4572853446006775},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.4394090473651886},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.43451637029647827},{"id":"https://openalex.org/C2777257650","wikidata":"https://www.wikidata.org/wiki/Q4833719","display_name":"B-cell lymphoma","level":3,"score":0.43362659215927124},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.42937609553337097},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.41073134541511536},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3787355124950409},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3484976887702942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28161025047302246},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.22660276293754578},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14170098304748535},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.13587686419487},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.07099023461341858},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6523203","doi":"https://doi.org/10.1158/1078-0432.c.6523203","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6523203","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6523203","doi":"https://doi.org/10.1158/1078-0432.c.6523203","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6523203","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2013144228","https://openalex.org/W2170931794","https://openalex.org/W1979269885","https://openalex.org/W2979419101","https://openalex.org/W2080939719","https://openalex.org/W4293770031","https://openalex.org/W4401394659","https://openalex.org/W2119325469","https://openalex.org/W2591284615","https://openalex.org/W2906274516"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"To":[2],"evaluate":[3],"the":[4,137,143,157,189,192,201,210,226,241],"pharmacologic":[5],"activity":[6,42,66,190],"of":[7,11,20,43,57,67,78,91,131,139,147,160,179,184,191,209,214,243],"a":[8,26,153,206,235],"novel":[9,236],"inhibitor":[10,203],"I\u03baB":[12],"kinase":[13],"\u03b2":[14],"(IKK2),":[15],"LY2409881,":[16],"in":[17,30,40,59,64,97,126,152,196,229],"preclinical":[18],"models":[19,130],"B-":[21,244],"and":[22,29,53,85,107,117,120,124,175,237,245],"T-cell":[23,246],"lymphoma,":[24],"as":[25],"single":[27],"agent":[28],"combination":[31,108,230],"with":[32,93,142,231],"histone":[33],"deacetylase":[34],"(HDAC)":[35],"inhibitors.":[36],"Experimental":[37],"Design:":[38],"The":[39,63,76],"vitro":[41],"LY2409881":[44,68,92,112,140,164,187],"was":[45,69,80,99,165],"determined":[46,70,81,100],"using":[47,71,82],"an":[48],"ATP-based":[49],"growth":[50,122],"inhibition":[51,123,183],"assay":[52,56],"flow":[54],"cytometric":[55],"apoptosis":[58,125],"lymphoma":[60,98,127,135,197],"cell":[61,162],"lines.":[62,163],"vivo":[65],"SCID-beige":[72],"xenograft":[73],"mouse":[74],"model.":[75],"mechanism":[77,208],"action":[79],"immunoblotting,":[83],"immuofluorescence,":[84],"electrophoretic":[86],"mobility":[87],"shift":[88],"assay.":[89],"Synergy":[90],"other":[94],"drugs":[95],"active":[96],"by":[101,156,200],"calculating":[102],"relative":[103],"risk":[104],"ratio":[105],"(RRR)":[106],"index":[109],"(CI).":[110],"Results:":[111],"inhibited":[113],"constitutively":[114],"activated":[115],"NF-\u03baB,":[116,148],"caused":[118,181],"concentration-":[119],"time-dependent":[121],"cells.":[128],"In":[129],"diffuse":[132],"large":[133],"B-cell":[134],"(DLBCL),":[136],"cytotoxicity":[138],"correlated":[141],"overall":[144],"activation":[145],"status":[146],"but":[149],"not":[150],"simply":[151],"pattern":[154],"predicted":[155],"cell-of-origin":[158],"classification":[159],"these":[161,215,220],"safe":[166],"to":[167],"mice":[168],"at":[169],"three":[170],"dose":[171],"levels,":[172],"50,":[173],"100,":[174],"200":[176],"mg/kg,":[177],"all":[178],"which":[180],"significant":[182],"tumor":[185],"growth.":[186],"suppressed":[188],"NF-\u03baB":[193,227],"subunit":[194],"p65":[195],"cells":[198],"treated":[199],"HDAC":[202],"romidepsin,":[204],"underlying":[205],"potential":[207],"marked":[211],"synergy":[212],"observed":[213],"two":[216],"drugs.":[217],"Conclusion:":[218],"Collectively,":[219],"data":[221],"strongly":[222],"suggest":[223],"that":[224],"targeting":[225],"pathway":[228],"romidepsin":[232],"could":[233],"represent":[234],"potent":[238],"regimen":[239],"for":[240],"treatment":[242],"lymphoma.":[247],"Clin":[248],"Cancer":[249],"Res;":[250],"21(1);":[251],"134\u201345.":[252],"\u00a92014":[253],"AACR.":[254]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
