{"id":"https://openalex.org/W4361944993","doi":"https://doi.org/10.1158/1078-0432.c.6521748","title":"Data from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem\u2013like Cells in S/G2/M Phases","display_name":"Data from A Genetically Engineered Oncolytic Adenovirus Decoys and Lethally Traps Quiescent Cancer Stem\u2013like Cells in S/G2/M Phases","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361944993","doi":"https://doi.org/10.1158/1078-0432.c.6521748"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6521748","doi":"https://doi.org/10.1158/1078-0432.c.6521748","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6521748","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6521748","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062335013","display_name":"Shuya Yano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shuya Yano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015421086","display_name":"Hiroshi Tazawa","orcid":"https://orcid.org/0000-0003-4658-1050","observed_orcids":["https://orcid.org/0000-0003-4658-1050"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroshi Tazawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101481270","display_name":"Yuuri Hashimoto","orcid":"https://orcid.org/0000-0002-5934-6060","observed_orcids":["https://orcid.org/0000-0002-5934-6060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuuri Hashimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055129091","display_name":"Yasuhiro Shirakawa","orcid":"https://orcid.org/0000-0003-4698-5119","observed_orcids":["https://orcid.org/0000-0003-4698-5119"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuhiro Shirakawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020188029","display_name":"Shinji Kuroda","orcid":"https://orcid.org/0000-0002-4484-1253","observed_orcids":["https://orcid.org/0000-0002-4484-1253"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shinji Kuroda","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111619755","display_name":"Masahiko Nishizaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masahiko Nishizaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035456514","display_name":"Hiroyuki Kishimoto","orcid":"https://orcid.org/0000-0001-8174-3508","observed_orcids":["https://orcid.org/0000-0001-8174-3508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hiroyuki Kishimoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014758676","display_name":"Futoshi Uno","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Futoshi Uno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055180271","display_name":"Takeshi Nagasaka","orcid":"https://orcid.org/0000-0002-4236-350X","observed_orcids":["https://orcid.org/0000-0002-4236-350X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Takeshi Nagasaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045812","display_name":"Yasuo Urata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yasuo Urata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049100460","display_name":"Shunsuke Kagawa","orcid":"https://orcid.org/0000-0002-3610-8211","observed_orcids":["https://orcid.org/0000-0002-3610-8211"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shunsuke Kagawa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040819666","display_name":"Robert M. Hoffman","orcid":"https://orcid.org/0000-0002-0049-0041","observed_orcids":["https://orcid.org/0000-0002-0049-0041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert M. Hoffman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5068717107","display_name":"Toshiyoshi Fujiwara","orcid":"https://orcid.org/0000-0002-5377-6051","observed_orcids":["https://orcid.org/0000-0002-5377-6051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Toshiyoshi Fujiwara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.9785000085830688,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-adenovirus","display_name":"oncolytic adenovirus","score":0.9940000176429749},{"id":"https://openalex.org/keywords/obp-301","display_name":"OBP-301","score":0.9800000190734863},{"id":"https://openalex.org/keywords/telomerase","display_name":"telomerase","score":0.8050000071525574},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.921999990940094},{"id":"https://openalex.org/keywords/quiescent-tumor-cells","display_name":"quiescent cancer cells","score":0.859000027179718},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cd133","display_name":"CD133","score":0.9229999780654907},{"id":"https://openalex.org/keywords/s-and-g2-m-phases","display_name":"S/G2/M phase","score":0.7870000004768372},{"id":"https://openalex.org/keywords/fucci","display_name":"FUCCI","score":0.7310000061988831},{"id":"https://openalex.org/keywords/tumor-spheres","display_name":"tumor spheres","score":0.7089999914169312},{"id":"https://openalex.org/keywords/chemoradiotherapy-resistance","display_name":"chemoradiotherapy resistance","score":0.7910000085830688},{"id":"https://openalex.org/keywords/chemosensitization","display_name":"chemosensitization","score":0.5830000042915344},{"id":"https://openalex.org/keywords/xenografts","display_name":"xenografts","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6063762307167053},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5947576761245728},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.5938206911087036},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.522413969039917},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5202673673629761},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5016653537750244},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.4485361874103546},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42627984285354614},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3872019052505493},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34829914569854736},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.16390913724899292},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09788012504577637}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.c.6521748","doi":"https://doi.org/10.1158/1078-0432.c.6521748","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6521748","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.c.6521748.v1","doi":"https://doi.org/10.1158/1078-0432.c.6521748.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6521748.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6521748","doi":"https://doi.org/10.1158/1078-0432.c.6521748","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6521748","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2100808704","https://openalex.org/W2246117389","https://openalex.org/W2027776792","https://openalex.org/W2755433594","https://openalex.org/W7095436271","https://openalex.org/W2590176894","https://openalex.org/W2101347907","https://openalex.org/W1593629705","https://openalex.org/W2170072668","https://openalex.org/W2886197593"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Because":[2],"chemoradiotherapy":[3],"selectively":[4],"targets":[5],"proliferating":[6,177],"cancer":[7,10,44,70,78,84,97,110,129,138,160,173,194,210,226,242,247,258],"cells,":[8],"quiescent":[9,21,43,69,96,109,158,171,209,257],"stem\u2013like":[11,45,71,79,98,111,139,161,174,180,195,211,227,259],"cells":[12,24,46,80,112,130,140,162,175,196,212],"are":[13],"resistant.":[14],"Mobilization":[15],"of":[16,37,55,93,105,108,170,184,241],"the":[17,38,53,64,91,102,185],"cell":[18,28,39,65,155,228,243],"cycle":[19,40,66],"in":[20,47,113,157,188,201,213,245],"leukemia":[22],"stem":[23],"sensitizes":[25],"them":[26],"to":[27,62,142,150,255],"death":[29,156],"signals.":[30],"However,":[31],"it":[32],"is":[33,237],"unclear":[34],"that":[35,192,206],"mobilization":[36,147],"can":[41,249],"eliminate":[42,256],"solid":[48,246],"cancers.":[49],"Thus,":[50],"we":[51],"explored":[52],"use":[54],"a":[56,120,251],"genetically-engineered":[57],"telomerase-specific":[58],"oncolytic":[59],"adenovirus,":[60],"OBP-301,":[61],"mobilize":[63],"and":[67,86,117,153,176,216,225,230,248],"kill":[68],"cells.":[72,88,99,181,260],"Experimental":[73],"Design:":[74],"We":[75,89,100,204],"established":[76],"CD133+":[77,127,137,159,172,193],"from":[81,148],"human":[82],"gastric":[83,128],"MKN45":[85],"MKN7":[87],"investigated":[90],"efficacy":[92],"OBP-301":[94,106,134,144,207],"against":[95],"visualized":[101],"treatment":[103],"dynamics":[104],"killing":[107,244],"dormant":[114],"tumor":[115,189,214],"spheres":[116,190,215],"xenografts":[118,217],"using":[119],"fluorescent":[121],"ubiquitination":[122],"cell-cycle":[123,146,186],"indicator":[124],"(FUCCI).":[125],"Results:":[126],"had":[131],"stemness":[132,198],"properties.":[133],"efficiently":[135],"killed":[136],"resistant":[141],"chemoradiotherapy.":[143],"induced":[145],"G0\u2013G1":[149,202],"S/G2/M":[151,219],"phases":[152,220],"subsequent":[154],"by":[163,199],"mobilizing":[164],"cell-cycle\u2013related":[165],"proteins.":[166],"FUCCI":[167],"enabled":[168],"visualization":[169,183],"CD133\u2212":[178],"non\u2013cancer":[179],"Three-dimensional":[182],"behavior":[187],"showed":[191,205],"maintained":[197],"remaining":[200],"phase.":[203],"mobilized":[208],"into":[218],"where":[221],"they":[222],"lost":[223],"viability":[224],"properties":[229],"became":[231],"chemosensitive.":[232],"Conclusion:":[233],"Oncolytic":[234],"adenoviral":[235],"infection":[236],"an":[238],"effective":[239],"mechanism":[240],"be":[250],"new":[252],"therapeutic":[253],"paradigm":[254],"Clin":[261],"Cancer":[262],"Res;":[263],"19(23);":[264],"6495\u2013505.":[265],"\u00a92013":[266],"AACR.":[267]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
