{"id":"https://openalex.org/W4361944901","doi":"https://doi.org/10.1158/1078-0432.c.6521792","title":"Data from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas","display_name":"Data from DNA Demethylating Agents Synergize with Oncolytic HSV1 against Malignant Gliomas","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361944901","doi":"https://doi.org/10.1158/1078-0432.c.6521792"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6521792","doi":"https://doi.org/10.1158/1078-0432.c.6521792","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6521792","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.c.6521792","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080146212","display_name":"Kazuo Okemoto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazuo Okemoto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075658818","display_name":"Kazue Kasai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kazue Kasai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087679522","display_name":"Benjamin Wagner","orcid":"https://orcid.org/0000-0003-2835-986X","observed_orcids":["https://orcid.org/0000-0003-2835-986X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Wagner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065457823","display_name":"Amy Haseley","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Haseley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024102436","display_name":"Hans Meisen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hans Meisen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035017270","display_name":"Chelsea M. Bolyard","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chelsea Bolyard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015153331","display_name":"Xiaokui Molly Mo","orcid":"https://orcid.org/0000-0002-9797-2687","observed_orcids":["https://orcid.org/0000-0002-9797-2687"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaokui Mo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085195592","display_name":"Allison M. Wehr","orcid":"https://orcid.org/0009-0006-4589-1099","observed_orcids":["https://orcid.org/0009-0006-4589-1099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Allison Wehr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109936147","display_name":"Amy Lehman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy Lehman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114126225","display_name":"Soledad Fern\u00e1ndez","orcid":"https://orcid.org/0009-0007-7848-9781","observed_orcids":["https://orcid.org/0009-0007-7848-9781"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soledad Fernandez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041131555","display_name":"Balveen Kaur","orcid":"https://orcid.org/0000-0001-7738-0804","observed_orcids":["https://orcid.org/0000-0001-7738-0804"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Balveen Kaur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5033917464","display_name":"Ennio Antonio Chiocca","orcid":"https://orcid.org/0000-0001-5183-1670","observed_orcids":["https://orcid.org/0000-0001-5183-1670"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E. Antonio Chiocca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.8827999830245972,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.07419999688863754,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oncolytic-herpes-simplex-virus-type-1","display_name":"oncolytic herpes simplex virus type 1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/high-grade-glioma","display_name":"high-grade glioma","score":0.8949999809265137},{"id":"https://openalex.org/keywords/hypomethylating-agents","display_name":"hypomethylating agents","score":0.9610000252723694},{"id":"https://openalex.org/keywords/azacitidine","display_name":"azacitidine","score":0.9800000190734863},{"id":"https://openalex.org/keywords/decitabine","display_name":"decitabine","score":1.0},{"id":"https://openalex.org/keywords/valproic-acid","display_name":"valproic acid","score":1.0},{"id":"https://openalex.org/keywords/nestin-promoter","display_name":"nestin promoter","score":0.8019999861717224},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.6190000176429749},{"id":"https://openalex.org/keywords/glioma-xenografts","display_name":"glioma xenografts","score":0.8640000224113464},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.3659999966621399}],"concepts":[{"id":"https://openalex.org/C2779277951","wikidata":"https://www.wikidata.org/wiki/Q5255196","display_name":"Demethylating agent","level":5,"score":0.943529486656189},{"id":"https://openalex.org/C2780235182","wikidata":"https://www.wikidata.org/wiki/Q1181878","display_name":"Decitabine","level":5,"score":0.7876982688903809},{"id":"https://openalex.org/C82210918","wikidata":"https://www.wikidata.org/wiki/Q1560099","display_name":"Oncolytic virus","level":3,"score":0.6753891706466675},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6163681745529175},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6090519428253174},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5879241228103638},{"id":"https://openalex.org/C2776239401","wikidata":"https://www.wikidata.org/wiki/Q416451","display_name":"Azacitidine","level":5,"score":0.4733438789844513},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.41653797030448914},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.38517093658447266},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.35231757164001465},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2926347851753235},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.23898959159851074},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.06949016451835632},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06808838248252869},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06734231114387512},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6521792","doi":"https://doi.org/10.1158/1078-0432.c.6521792","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6521792","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6521792","doi":"https://doi.org/10.1158/1078-0432.c.6521792","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.c.6521792","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2104348730","https://openalex.org/W2324511114","https://openalex.org/W2159723167","https://openalex.org/W7126358953","https://openalex.org/W3191034723","https://openalex.org/W3128982080","https://openalex.org/W2313189849","https://openalex.org/W2414509287","https://openalex.org/W3099618098","https://openalex.org/W2609292283"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Oncolytic":[2],"viruses":[3],"(OV)":[4],"based":[5],"on":[6,113],"herpes":[7],"simplex":[8],"virus":[9],"type":[10],"1":[11],"(HSV1)":[12],"are":[13],"being":[14],"used":[15,60],"in":[16,37,50,70,72,75,106,109,164],"clinical":[17,169],"trials":[18,170],"for":[19,152,171],"a":[20,28],"variety":[21],"of":[22,87,93,120,133,155],"cancers.":[23],"The":[24,91],"OV,":[25,162],"rQNestin34.5,":[26,163],"uses":[27],"nestin":[29],"promoter/enhancer":[30],"to":[31,80],"selectively":[32],"drive":[33],"robust":[34],"viral":[35],"replication":[36,101],"malignant":[38,77,172],"glioma":[39,52,78,139],"cells.":[40],"We":[41,59],"have":[42],"discovered":[43],"that":[44],"this":[45],"promoter":[46],"becomes":[47],"extensively":[48],"methylated":[49],"infected":[51],"cells,":[53],"reducing":[54],"OV":[55,100],"efficacy.":[56],"Experimental":[57],"Design:":[58],"demethylating":[61,94,122,156],"drugs":[62],"[5-azacytidine":[63],"(5-Aza)],":[64],"decitabine,":[65,126],"or":[66,125],"valproic":[67],"acid":[68],"(VPA)":[69],"both":[71],"vitro":[73,107],"and":[74,102],"vivo":[76],"models":[79],"determine":[81],"if":[82],"they":[83],"improved":[84,99],"the":[85,118,121,131,153,161],"efficacy":[86],"rQNestin34.5":[88,128],"therapy.":[89],"Results:":[90],"use":[92],"agents,":[95,123],"such":[96],"as":[97],"5-Aza,":[98],"tumor":[103],"cell":[104],"lysis":[105],"and,":[108,167],"fact,":[110],"synergized":[111],"pharmacologically":[112],"Chou\u2013Talalay":[114],"analysis.":[115],"In":[116],"vivo,":[117],"combination":[119],"5-Aza":[124],"with":[127,160],"significantly":[129],"prolonged":[130],"survivorship":[132],"athymic":[134],"mice":[135],"harboring":[136],"intracranial":[137],"human":[138],"xenografts":[140],"over":[141],"single":[142],"agent":[143],"alone.":[144],"Conclusion:":[145],"These":[146],"results,":[147],"thus,":[148],"provide":[149],"further":[150],"justification":[151],"exploration":[154],"agents":[157],"when":[158],"combined":[159],"preclinical":[165],"therapeutics":[166],"possibly,":[168],"glioma.":[173],"Clin":[174],"Cancer":[175],"Res;":[176],"19(21);":[177],"5952\u20139.":[178],"\u00a92013":[179],"AACR.":[180]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
