{"id":"https://openalex.org/W4361944889","doi":"https://doi.org/10.1158/1078-0432.c.6521316","title":"Data from Molecular Imaging of Death Receptor 5 Occupancy and Saturation Kinetics In Vivo by Humanized Monoclonal Antibody CS-1008","display_name":"Data from Molecular Imaging of Death Receptor 5 Occupancy and Saturation Kinetics In Vivo by Humanized Monoclonal Antibody CS-1008","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361944889","doi":"https://doi.org/10.1158/1078-0432.c.6521316"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6521316","doi":"https://doi.org/10.1158/1078-0432.c.6521316","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6521316","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6521316","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016189625","display_name":"Ingrid J.G. Burvenich","orcid":"https://orcid.org/0000-0001-8384-2403","observed_orcids":["https://orcid.org/0000-0001-8384-2403"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ingrid J.G. Burvenich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034686081","display_name":"Fook-Thean Lee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fook T. Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060934446","display_name":"Glenn A. Cartwright","orcid":"https://orcid.org/0009-0006-6008-6354","observed_orcids":["https://orcid.org/0009-0006-6008-6354"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Glenn A. Cartwright","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025399748","display_name":"Graeme Joseph O'Keefe","orcid":"https://orcid.org/0000-0002-8538-6170","observed_orcids":["https://orcid.org/0000-0002-8538-6170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graeme J. O'Keefe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025668228","display_name":"Dahna Makris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dahna Makris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080963542","display_name":"Diana Cao","orcid":"https://orcid.org/0000-0002-6083-837X","observed_orcids":["https://orcid.org/0000-0002-6083-837X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Diana Cao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112959976","display_name":"Sylvia Jie Gong","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sylvia Gong","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031778162","display_name":"Anderly C. Ch\u00fceh","orcid":"https://orcid.org/0000-0003-1140-5516","observed_orcids":["https://orcid.org/0000-0003-1140-5516"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anderly C. Chueh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038419173","display_name":"John  Martin Mariadason","orcid":"https://orcid.org/0000-0001-9123-7684","observed_orcids":["https://orcid.org/0000-0001-9123-7684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Mariadason","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002401816","display_name":"Martin W. Brechbiel","orcid":"https://orcid.org/0000-0002-4012-1400","observed_orcids":["https://orcid.org/0000-0002-4012-1400"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin W. Brechbiel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027438799","display_name":"Robert A. Beckman","orcid":"https://orcid.org/0000-0003-0098-9210","observed_orcids":["https://orcid.org/0000-0003-0098-9210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Beckman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Kosaku Fujiwara","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kosaku Fujiwara","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013979917","display_name":"Reinhard von Roemeling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reinhard von Roemeling","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078312966","display_name":"Andrew Mark Scott","orcid":"https://orcid.org/0000-0002-6656-295X","observed_orcids":["https://orcid.org/0000-0002-6656-295X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew M. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.9549999833106995},{"id":"https://openalex.org/keywords/111in-labeled-antibody","display_name":"111In-labeled antibody","score":0.8759999871253967},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.8109999895095825},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-biodistribution","display_name":"tumor biodistribution","score":0.5080000162124634},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8299999833106995},{"id":"https://openalex.org/keywords/radiolabeled-antibodies","display_name":"radiolabeled antibodies","score":0.4909999966621399},{"id":"https://openalex.org/keywords/molecular-imaging","display_name":"molecular imaging","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6344703435897827},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6010524034500122},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4920651316642761},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4690530598163605},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46243274211883545},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16381192207336426},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1456334888935089},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6521316","doi":"https://doi.org/10.1158/1078-0432.c.6521316","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6521316","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6521316","doi":"https://doi.org/10.1158/1078-0432.c.6521316","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6521316","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2149846334","https://openalex.org/W2116541902","https://openalex.org/W3011245603","https://openalex.org/W2008430091","https://openalex.org/W7134240069","https://openalex.org/W2248073252","https://openalex.org/W2107610558","https://openalex.org/W1993799683","https://openalex.org/W2148098988","https://openalex.org/W2063217671"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"CS-1008":[2,36,62,137],"(tigatuzumab;":[3],"phase":[4],"I/II),":[5],"an":[6],"antihuman":[7],"death":[8],"receptor":[9,55,115,216,241],"5":[10],"(DR5)":[11],"agonist,":[12],"induces":[13],"apoptosis":[14],"and":[15,50,65,70,81,84,106,124,147,170,180,193,224,228,243],"has":[16],"cytotoxic":[17],"activity":[18],"against":[19],"human":[20],"cancer":[21,49,77],"cell":[22],"lines.":[23],"This":[24],"study":[25,42,114],"reports":[26],"on":[27,73,177],"the":[28,43,252],"preclinical":[29],"validation":[30],"of":[31,133,199,203,214,247],"111In-labeled":[32,134,136,200],"anti-DR5":[33],"humanized":[34],"antibody":[35],"as":[37],"a":[38,230],"diagnostic":[39],"tool":[40],"to":[41,113,206,239],"DR5":[44,68,175,183,204,215,248],"occupancy":[45,116,217,242],"in":[46,58,89,117,142,187,208,218,225,251],"patients":[47],"with":[48,150,174,221],"establish":[51],"dose":[52,245],"ranges":[53],"for":[54,67],"saturation":[56,184],"kinetics":[57],"vivo.":[59,118],"Experimental":[60],"Design:":[61],"was":[63,138,185],"radiolabeled":[64],"characterized":[66],"binding":[69,126],"labeling":[71],"efficiency":[72],"TRAIL-sensitive":[74],"DR5\u2013positive":[75],"colorectal":[76],"cells":[78,179],"(COLO":[79],"205":[80,146],"WiDr).":[82],"Pharmacokinetic":[83],"biodistribution":[85,191],"studies":[86,192],"were":[87,111],"conducted":[88],"BALB/c":[90],"nu/nu":[91],"mice":[92,143],"bearing":[93,144],"COLO":[94,145],"205,":[95],"WiDr,":[96],"or":[97],"DR5-negative":[98],"CT26":[99],"colon":[100],"tumors.":[101],"Planar":[102],"gamma":[103,195],"camera":[104,196],"imaging":[105,198,233],"computerized":[107],"tomography":[108],"(CT)":[109],"images":[110],"obtained":[112],"Results:":[119],"Scatchard":[120],"analysis":[121],"showed":[122],"high":[123],"specific":[125],"affinity":[127],"(Kd,":[128],"1.05":[129],"\u00b1":[130,155,159],"0.12":[131],"nmol/L)":[132],"CS-1008.":[135,201],"specifically":[139],"taken":[140],"up":[141],"WiDr":[148],"tumors":[149],"prolonged":[151],"tumor":[152,178,222],"retention":[153],"(26.25":[154],"2.85%ID/g":[156],"vs.":[157],"12.20":[158],"2.24":[160],"at":[161],"168":[162],"hours":[163],"post":[164],"injection;":[165],"n":[166],"=":[167],"5,":[168],"SD),":[169],"uptake":[171],"correlated":[172],"both":[173,190],"expression":[176],"antitumor":[181,210],"activity.":[182],"shown":[186],"vivo":[188,209,219,226],"via":[189],"planar":[194],"imaging/CT":[197],"Saturation":[202],"corresponded":[205],"maximal":[207],"efficacy.":[211],"Conclusions:":[212],"Imaging":[213],"correlates":[220],"concentration":[223],"efficacy,":[227],"is":[229],"novel":[231],"molecular":[232],"technique":[234],"that":[235],"can":[236],"be":[237],"used":[238],"determine":[240],"effective":[244],"levels":[246],"agonist":[249],"antibodies":[250],"clinic.":[253],"Clin":[254],"Cancer":[255],"Res;":[256],"19(21);":[257],"5984\u201393.":[258],"\u00a92013":[259],"AACR.":[260]},"counts_by_year":[],"updated_date":"2026-10-13T10:08:12.033832","created_date":"2023-04-05T00:00:00"}
