{"id":"https://openalex.org/W4361944206","doi":"https://doi.org/10.1158/1078-0432.c.6520011","title":"Data from Increase in Cholesterol Predicts Survival Advantage in Renal Cell Carcinoma Patients Treated with Temsirolimus","display_name":"Data from Increase in Cholesterol Predicts Survival Advantage in Renal Cell Carcinoma Patients Treated with Temsirolimus","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361944206","doi":"https://doi.org/10.1158/1078-0432.c.6520011"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6520011","doi":"https://doi.org/10.1158/1078-0432.c.6520011","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6520011","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6520011","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071066396","display_name":"Chee Khoon Lee","orcid":"https://orcid.org/0000-0003-2955-9820","observed_orcids":["https://orcid.org/0000-0003-2955-9820"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chee Khoon Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003569285","display_name":"Ian C. Marschner","orcid":"https://orcid.org/0000-0002-6225-1572","observed_orcids":["https://orcid.org/0000-0002-6225-1572"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian C. Marschner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057755054","display_name":"R. John Simes","orcid":"https://orcid.org/0000-0002-3740-7563","observed_orcids":["https://orcid.org/0000-0002-3740-7563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R. John Simes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082847955","display_name":"Merryn Voysey","orcid":"https://orcid.org/0000-0001-6324-6559","observed_orcids":["https://orcid.org/0000-0001-6324-6559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Merryn Voysey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010363332","display_name":"Brian Lee Egleston","orcid":"https://orcid.org/0000-0002-1633-799X","observed_orcids":["https://orcid.org/0000-0002-1633-799X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Brian Egleston","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109218670","display_name":"Gary R. Hudes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Hudes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008701409","display_name":"Paul DE SOUZA","orcid":"https://orcid.org/0000-0002-7380-1170","observed_orcids":["https://orcid.org/0000-0002-7380-1170"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul de Souza","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/temsirolimus","display_name":"temsirolimus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/renal-cell-carcinoma","display_name":"renal cell carcinoma","score":0.9769999980926514},{"id":"https://openalex.org/keywords/serum-cholesterol","display_name":"serum cholesterol","score":0.828000009059906},{"id":"https://openalex.org/keywords/triglycerides","display_name":"triglycerides","score":0.9900000095367432},{"id":"https://openalex.org/keywords/blood-glucose","display_name":"blood glucose","score":0.7950000166893005},{"id":"https://openalex.org/keywords/treatment-response-biomarkers","display_name":"treatment response biomarkers","score":0.6769999861717224},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7639999985694885},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":1.0},{"id":"https://openalex.org/keywords/mtor-inhibitors","display_name":"mTOR inhibitors","score":0.8709999918937683},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.7990000247955322},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7590000033378601},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.5870000123977661},{"id":"https://openalex.org/keywords/hyperglycemia","display_name":"hyperglycemia","score":0.9409999847412109},{"id":"https://openalex.org/keywords/hypertriglyceridemia","display_name":"hypertriglyceridemia","score":0.7540000081062317}],"concepts":[{"id":"https://openalex.org/C2776820818","wikidata":"https://www.wikidata.org/wiki/Q7699074","display_name":"Temsirolimus","level":5,"score":0.9296947121620178},{"id":"https://openalex.org/C2777472916","wikidata":"https://www.wikidata.org/wiki/Q1164529","display_name":"Renal cell carcinoma","level":2,"score":0.733368992805481},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.6238688826560974},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6129182577133179},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.5211943984031677},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4769805371761322},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.363187313079834},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.23737943172454834},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.10402017831802368},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.10226455330848694},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07357227802276611},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.07080677151679993}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6520011","doi":"https://doi.org/10.1158/1078-0432.c.6520011","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6520011","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6520011","doi":"https://doi.org/10.1158/1078-0432.c.6520011","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6520011","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2135637416","https://openalex.org/W4361880807","https://openalex.org/W2528378766","https://openalex.org/W2258391373","https://openalex.org/W2921975085","https://openalex.org/W2077413140","https://openalex.org/W4411068347","https://openalex.org/W2121042421","https://openalex.org/W2121291141","https://openalex.org/W1827792674"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"Temsirolimus":[2,102,177,213],"is":[3,12,250],"an":[4],"effective":[5],"treatment":[6],"for":[7,194,237,254],"renal":[8],"cell":[9],"carcinoma.":[10],"It":[11],"associated":[13,104,155],"with":[14,75,105,130,156,186,226,262,268],"increases":[15,108,270],"in":[16,51,70,109,229,259,266,271],"serum":[17],"cholesterol,":[18,40],"triglyceride,":[19],"and":[20,42,79,122,132,243],"glucose.":[21],"We":[22,35,83],"investigated":[23],"whether":[24],"changes":[25,69,90],"of":[26,39,91,97,231,277],"these":[27,71,92,238],"biomarkers":[28,72,93],"could":[29],"predict":[30,94,221],"its":[31,182,222],"efficacy.":[32,256],"Experimental":[33],"Design:":[34],"examined":[36],"serial":[37],"measurements":[38],"triglycerides,":[41],"glucose":[43,123,218],"from":[44,73],"patients":[45,260],"randomized":[46],"to":[47,88],"IFN":[48,131],"or":[49,217,279],"temsirolimus":[50,98,232,255,263,278],"the":[52,66,86,95],"Global":[53],"Advanced":[54],"Renal":[55],"Cell":[56],"Carcinoma":[57],"Trial.":[58],"Using":[59],"time-dependent":[60],"proportional":[61],"hazards":[62],"models,":[63],"we":[64],"quantified":[65],"association":[67],"between":[68],"baseline":[74],"overall":[76],"survival":[77,81,134,158,185,189,227,258],"(OS)":[78],"progression-free":[80],"(PFS).":[82],"also":[84],"assess":[85],"extent":[87],"which":[89],"effects":[96],"on":[99,179,184,215,224],"survival.":[100],"Results:":[101],"was":[103,154,264],"larger":[106,269],"mean":[107],"cholesterol":[110,180,195],"(1.02":[111],"mmol/L;":[112,118,125,173],"P":[113,119,126,140,147,165,174,203,210,244],"<":[114,127,166,175],"0.0001),":[115],"triglycerides":[116,216],"(0.32":[117],"=":[120,138,141,145,148,161,170,201,204,208,211,241,245],"0.0008),":[121],"(1.28":[124],"0.0001)":[128],"compared":[129],"improved":[133],"rate":[135],"(OS:":[136,159,199],"HR":[137,144,160,169,200,207],"0.76,":[139],"0.02;":[142],"PFS:":[143,168,206],"0.70,":[146],"0.001).":[149],"Cholesterol":[150,248],"increase":[151,249],"during":[152,197],"study":[153,198],"longer":[157],"0.77":[162],"per":[163,172],"mmol/L,":[164],"0.0001;":[167],"0.81":[171],"0.0001).":[176],"effect":[178,183,214,223],"predicted":[181],"no":[187],"additional":[188],"advantage":[190,228],"observed":[191,234,265],"after":[192,235],"adjusting":[193,236],"change":[196],"1.14,":[202],"0.37;":[205],"0.88,":[209],"0.35).":[212],"did":[219],"not":[220],"survival,":[225],"favor":[230],"still":[233],"factors":[239],"(P":[240],"0.003":[242],"0.002).":[246],"Conclusion:":[247],"a":[251],"potential":[252],"predictor":[253],"Longer":[257],"treated":[261],"those":[267],"cholesterol.":[272],"Prospectively":[273],"designed":[274],"biomarker":[275],"studies":[276],"other":[280],"mTOR":[281],"inhibitors":[282],"are":[283],"recommended.":[284],"Clin":[285],"Cancer":[286],"Res;":[287],"18(11);":[288],"3188\u201396.":[289],"\u00a92012":[290],"AACR.":[291]},"counts_by_year":[],"updated_date":"2026-09-27T08:07:27.782135","created_date":"2023-04-05T00:00:00"}