{"id":"https://openalex.org/W4361942999","doi":"https://doi.org/10.1158/1078-0432.c.6517674","title":"Data from Effect of Granulocyte/Macrophage Colony-Stimulating Factor on Vaccination with an Allogeneic Whole-Cell Melanoma Vaccine","display_name":"Data from Effect of Granulocyte/Macrophage Colony-Stimulating Factor on Vaccination with an Allogeneic Whole-Cell Melanoma Vaccine","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361942999","doi":"https://doi.org/10.1158/1078-0432.c.6517674"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.c.6517674","doi":"https://doi.org/10.1158/1078-0432.c.6517674","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6517674","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.c.6517674","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080404941","display_name":"Mark B. Faries","orcid":"https://orcid.org/0000-0003-1752-7282","observed_orcids":["https://orcid.org/0000-0003-1752-7282"]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mark B. Faries","raw_affiliation_strings":["John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","institution_ids":[]},{"raw_affiliation_string":"Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025558951","display_name":"Eddy C. Hsueh","orcid":"https://orcid.org/0000-0002-0327-2605","observed_orcids":["https://orcid.org/0000-0002-0327-2605"]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eddy C. Hsueh","raw_affiliation_strings":["John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","institution_ids":[]},{"raw_affiliation_string":"Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102026223","display_name":"Xing Ye","orcid":"https://orcid.org/0000-0003-1769-6035","observed_orcids":["https://orcid.org/0000-0003-1769-6035"]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Ye","raw_affiliation_strings":["John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","institution_ids":[]},{"raw_affiliation_string":"Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Mary Hoban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary Hoban","raw_affiliation_strings":["John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","institution_ids":[]},{"raw_affiliation_string":"Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California","institution_ids":["https://openalex.org/I4210104056"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108822398","display_name":"Donald L. Morton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104056","display_name":"Saint John's Health Center","ror":"https://ror.org/01gcc9p15","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210104056","https://openalex.org/I94396219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald L. Morton","raw_affiliation_strings":["John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"John Wayne Cancer Institute, 2200 Santa Monica Boulevard, Santa Monica, CA 90404","institution_ids":[]},{"raw_affiliation_string":"Vaccine Laboratory of the Roy E. Coats Research Laboratories of the John Wayne Cancer Institute at Saint John's Health Center, Santa Monica, California","institution_ids":["https://openalex.org/I4210104056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5080404941"],"corresponding_institution_ids":["https://openalex.org/I4210104056"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9731000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.023800000548362732,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9869999885559082},{"id":"https://openalex.org/keywords/melanoma-vaccine","display_name":"melanoma vaccine","score":0.746999979019165},{"id":"https://openalex.org/keywords/immunoadjuvant","display_name":"immunoadjuvant","score":0.7509999871253967},{"id":"https://openalex.org/keywords/delayed-type-hypersensitivity","display_name":"delayed-type hypersensitivity","score":0.871999979019165},{"id":"https://openalex.org/keywords/antibody-response","display_name":"antibody response","score":0.8600000143051147},{"id":"https://openalex.org/keywords/eosinophils","display_name":"eosinophils","score":0.781000018119812},{"id":"https://openalex.org/keywords/basophils","display_name":"basophils","score":0.9570000171661377},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.7839999794960022},{"id":"https://openalex.org/keywords/melanoma-survival","display_name":"melanoma survival","score":0.6800000071525574},{"id":"https://openalex.org/keywords/resected-melanoma","display_name":"resected melanoma","score":0.7680000066757202},{"id":"https://openalex.org/keywords/surrogate-endpoints","display_name":"surrogate endpoints","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7080852389335632},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.689077615737915},{"id":"https://openalex.org/C2777478134","wikidata":"https://www.wikidata.org/wiki/Q423660","display_name":"Granulocyte macrophage colony-stimulating factor","level":3,"score":0.6604254245758057},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6428234577178955},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6307982206344604},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.5931538939476013},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.5066683888435364},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4659724235534668},{"id":"https://openalex.org/C2777983669","wikidata":"https://www.wikidata.org/wiki/Q223143","display_name":"Granulocyte","level":2,"score":0.464058518409729},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.21991103887557983},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.21264418959617615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.c.6517674","doi":"https://doi.org/10.1158/1078-0432.c.6517674","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6517674","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.c.6517674","doi":"https://doi.org/10.1158/1078-0432.c.6517674","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.c.6517674","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7235054391","display_name":"POLYVALENT VACCINE--PHASE III TRIAL IN STAGE IV MELANOMA","funder_award_id":"R01CA076489","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W180822945","https://openalex.org/W1493941926","https://openalex.org/W1906398111","https://openalex.org/W1938118789","https://openalex.org/W1965643834","https://openalex.org/W1980532772","https://openalex.org/W1982951034","https://openalex.org/W1991148746","https://openalex.org/W2009402217","https://openalex.org/W2030599507","https://openalex.org/W2032753327","https://openalex.org/W2036961863","https://openalex.org/W2038918212","https://openalex.org/W2041768004","https://openalex.org/W2053800140","https://openalex.org/W2067971586","https://openalex.org/W2081774451","https://openalex.org/W2085641163","https://openalex.org/W2093770967","https://openalex.org/W2099735866","https://openalex.org/W2124262559","https://openalex.org/W2134055893","https://openalex.org/W2146934263","https://openalex.org/W2148669766","https://openalex.org/W2150847030","https://openalex.org/W2151666328","https://openalex.org/W2158131681","https://openalex.org/W2160436685","https://openalex.org/W2164584613","https://openalex.org/W2335498812","https://openalex.org/W2418303347"],"related_works":["https://openalex.org/W2165502771","https://openalex.org/W2244266968","https://openalex.org/W2325971167","https://openalex.org/W4361949207","https://openalex.org/W2145513156","https://openalex.org/W2067930723","https://openalex.org/W2097000480","https://openalex.org/W2596519715","https://openalex.org/W2011653164","https://openalex.org/W2032347306"],"abstract_inverted_index":{"Abstract":[0],"Purpose:":[1],"The":[2,82,104],"availability":[3],"of":[4,7,17,42,45,204,213,230],"a":[5,53,74,166,227],"variety":[6],"immune":[8,124,154,184,206],"response":[9,89],"modifiers":[10],"creates":[11],"an":[12,112,159,183,205],"opportunity":[13],"for":[14,220],"improved":[15],"efficacy":[16],"immunotherapy,":[18],"but":[19],"it":[20,195],"also":[21,101,128],"leads":[22],"to":[23,27,32,38,50,72,90],"uncertainty":[24],"in":[25,114,142,149,161,186,217],"how":[26,31],"combine":[28],"agents":[29],"and":[30,70,98,121,144,165,189,191,208],"assess":[33,39],"those":[34],"combinations.":[35],"We":[36],"sought":[37],"the":[40,43,118,150,201,211],"effect":[41],"addition":[44],"granulocyte/macrophage":[46],"colony-stimulating":[47],"factor":[48],"(GM-CSF)":[49],"vaccination":[51],"with":[52,60,78,111,146,171,226],"melanoma":[54,62,76,91,163],"vaccine.":[55],"Experimental":[56],"Design:":[57],"Ninety-seven":[58],"patients":[59],"resected":[61],"(stage":[63],"II-IV)":[64],"were":[65,100,156],"enrolled,":[66],"stratified":[67],"by":[68,158],"stage,":[69],"randomized":[71],"receive":[73],"cellular":[75],"vaccine":[77],"or":[79],"without":[80],"GM-CSF.":[81,172],"primary":[83],"endpoint":[84,207],"was":[85],"delayed-type":[86,133],"hypersensitivity":[87,134],"(DTH)":[88],"cells.":[92],"Antibody":[93],"responses,":[94],"peripheral":[95],"leukocyte":[96,138],"counts,":[97],"survival":[99,170],"examined.":[102],"Results:":[103],"GM-CSF":[105,151,178],"arm":[106,127],"showed":[107,140],"enhanced":[108],"antibody":[109],"responses":[110],"increase":[113,160],"IgM":[115],"titer":[116],"against":[117],"TA90":[119,123],"antigen":[120],"increased":[122],"complexes.":[125],"This":[126],"had":[129],"diminished":[130],"antimelanoma":[131],"cell":[132],"response.":[135],"Peripheral":[136],"blood":[137],"profiles":[139],"increases":[141],"eosinophils":[143],"basophils":[145],"decreased":[147],"monocytes":[148],"arm.":[152],"These":[153,174],"changes":[155],"accompanied":[157],"early":[162],"deaths":[164],"trend":[167],"toward":[168],"worse":[169],"Conclusion:":[173],"data":[175],"suggest":[176],"that":[177,194],"is":[179],"not":[180],"helpful":[181],"as":[182],"adjuvant":[185],"this":[187],"dose":[188],"schedule":[190],"raise":[192],"concern":[193],"may":[196],"be":[197,224],"harmful.":[198],"Based":[199],"on":[200],"discordant":[202],"findings":[203],"clinical":[209],"outcome,":[210],"use":[212],"such":[214],"surrogate":[215],"endpoints":[216],"selecting":[218],"treatments":[219],"further":[221],"evaluation":[222],"must":[223],"done":[225],"great":[228],"deal":[229],"caution.":[231],"(Clin":[232],"Cancer":[233],"Res":[234],"2009;15(22):702935)":[235]},"counts_by_year":[],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2023-04-05T00:00:00"}
