{"id":"https://openalex.org/W4361942587","doi":"https://doi.org/10.1158/1055-9965.c.6516324","title":"Data from Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications","display_name":"Data from Benzene Uptake in Hookah Smokers and Non-smokers Attending Hookah Social Events: Regulatory Implications","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361942587","doi":"https://doi.org/10.1158/1055-9965.c.6516324"},"language":"en","primary_location":{"id":"doi:10.1158/1055-9965.c.6516324","doi":"https://doi.org/10.1158/1055-9965.c.6516324","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6516324","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1055-9965.c.6516324","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072817783","display_name":"Nada O. F. Kassem","orcid":"https://orcid.org/0000-0002-5403-7234","observed_orcids":["https://orcid.org/0000-0002-5403-7234"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nada O.F. Kassem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110967086","display_name":"Noura O. Kassem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Noura O. Kassem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027995728","display_name":"Sheila R. Jackson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sheila R. Jackson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023631147","display_name":"Sandy Liles","orcid":"https://orcid.org/0000-0003-3240-7799","observed_orcids":["https://orcid.org/0000-0003-3240-7799","https://orcid.org/0009-0000-5702-7624"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandy Liles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004489409","display_name":"Reem M. Daffa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Reem M. Daffa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048872194","display_name":"Adam T. Zarth","orcid":"https://orcid.org/0000-0001-8149-9517","observed_orcids":["https://orcid.org/0000-0001-8149-9517"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam T. Zarth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010658718","display_name":"Maram A. Younis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maram A. Younis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059851724","display_name":"Steven G. Carmella","orcid":"https://orcid.org/0000-0001-7383-5824","observed_orcids":["https://orcid.org/0000-0001-7383-5824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Steven G. Carmella","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086518872","display_name":"C. Richard Hofstetter","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. Richard Hofstetter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022956267","display_name":"Dale A. Chatfield","orcid":"https://orcid.org/0000-0002-0382-6073","observed_orcids":["https://orcid.org/0000-0002-0382-6073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dale A. Chatfield","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055765349","display_name":"Georg E. Matt","orcid":"https://orcid.org/0000-0001-5604-4609","observed_orcids":["https://orcid.org/0000-0001-5604-4609"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georg E. Matt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033402104","display_name":"Stephen S. Hecht","orcid":"https://orcid.org/0000-0001-7228-1356","observed_orcids":["https://orcid.org/0000-0001-7228-1356"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen S. Hecht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042461346","display_name":"Melbourne Frank Hovell","orcid":"https://orcid.org/0000-0001-7239-1627","observed_orcids":["https://orcid.org/0000-0001-7239-1627"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Melbourne F. Hovell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10060","display_name":"Smoking Behavior and Cessation","score":0.9175000190734863,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.05380000174045563,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/waterpipe-tobacco-smoking","display_name":"waterpipe smoking","score":0.890999972820282},{"id":"https://openalex.org/keywords/benzene-exposure","display_name":"benzene exposure","score":0.871999979019165},{"id":"https://openalex.org/keywords/s-phenylmercapturic-acid","display_name":"S-phenylmercapturic acid","score":0.9670000076293945},{"id":"https://openalex.org/keywords/urinary-biomarkers","display_name":"urinary biomarkers","score":0.6970000267028809},{"id":"https://openalex.org/keywords/passive-smoking","display_name":"passive smoking","score":0.871999979019165},{"id":"https://openalex.org/keywords/nonsmokers","display_name":"non-smokers","score":0.703000009059906},{"id":"https://openalex.org/keywords/indoor-air-quality-regulation","display_name":"indoor air quality regulation","score":0.656000018119812},{"id":"https://openalex.org/keywords/leukemia-risk","display_name":"leukemia risk","score":0.6959999799728394},{"id":"https://openalex.org/keywords/long-term-exposure","display_name":"long-term exposure","score":0.45500001311302185}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6012080907821655},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5140393972396851},{"id":"https://openalex.org/C19720800","wikidata":"https://www.wikidata.org/wiki/Q7722","display_name":"Morning","level":2,"score":0.5129156112670898},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.43179967999458313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.368982195854187}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1055-9965.c.6516324","doi":"https://doi.org/10.1158/1055-9965.c.6516324","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6516324","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1055-9965.c.6516324.v1","doi":"https://doi.org/10.1158/1055-9965.c.6516324.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1055-9965.c.6516324.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1055-9965.c.6516324","doi":"https://doi.org/10.1158/1055-9965.c.6516324","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1055-9965.c.6516324","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2018348138","https://openalex.org/W2794169897","https://openalex.org/W2622268844","https://openalex.org/W2897750542","https://openalex.org/W1965174529","https://openalex.org/W2182523929","https://openalex.org/W2734496845","https://openalex.org/W7099337833","https://openalex.org/W2880912508","https://openalex.org/W6906827091"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Benzene":[2],"is":[3,203,217],"a":[4,8,47,81,86,99,204,209],"human":[5],"hematotoxicant":[6],"and":[7,26,58,69,119,152,179,252],"leukemogen":[9],"that":[10],"causes":[11],"lymphohematopoietic":[12],"cancers,":[13],"especially":[14],"acute":[15],"myelogenous":[16],"leukemia.":[17,213],"We":[18,42],"investigated":[19],"uptake":[20,173],"of":[21,49,54,68,174,206,221,249],"benzene":[22,161,175,207],"in":[23,32,51,85,93,176,190,197,256],"hookah":[24,29,36,56,82,94,100,113,138,177,183,198,234,254],"smokers":[25,57,95,178],"non-smokers":[27,180],"attending":[28,73],"social":[30,78,101,188],"events":[31,115,125,140,189],"naturalistic":[33],"settings":[34],"where":[35],"tobacco":[37,184,201,235],"was":[38,108],"smoked":[39],"exclusively.":[40],"Methods:":[41],"quantified":[43],"S-phenylmercapturic":[44],"acid":[45],"(SPMA),":[46],"metabolite":[48],"benzene,":[50,224,246],"the":[52,66,70,169],"urine":[53,64],"105":[55],"103":[59],"non-smokers.":[60],"Participants":[61],"provided":[62],"spot":[63],"samples":[65],"morning":[67,71],"after":[72,112,123,137,153],"an":[74],"indoor":[75,258],"hookah-only":[76],"smoking":[77,255],"event":[79,102],"at":[80,187],"lounge":[83,114,139],"or":[84,232],"private":[87,191],"home.":[88],"Results:":[89],"Urinary":[90],"SPMA":[91,132,147],"levels":[92,133,148],"increased":[96,134],"significantly":[97],"following":[98],"(P":[103,116,126,141,162],"<":[104,117],"0.001).":[105],"This":[106],"increase":[107],"4.2":[109],"times":[110,121,136],"higher":[111,122],"0.001)":[118],"1.9":[120],"home":[124,154],"=":[127,142,163],"0.003).":[128],"In":[129],"non-smokers,":[130],"urinary":[131,146],"2.6":[135],"0.055);":[143],"however,":[144],"similar":[145],"were":[149],"detected":[150],"before":[151],"events,":[155],"possibly":[156],"indicating":[157],"chronic":[158],"exposure":[159,222,242],"to":[160,182,223,230,239,243],"0.933).":[164],"Conclusions:":[165],"Our":[166],"data":[167],"provide":[168],"first":[170],"evidence":[171],"for":[172,212,228],"exposed":[181],"secondhand":[185],"smoke":[186,202],"homes":[192],"compared":[193],"with":[194],"their":[195],"counterparts":[196],"lounges.":[199],"Hookah":[200],"source":[205],"exposure,":[208],"risk":[210],"factor":[211],"Impact:":[214],"Because":[215],"there":[216],"no":[218],"safe":[219],"level":[220],"our":[225],"results":[226],"call":[227],"interventions":[229],"reduce":[231],"prevent":[233],"use,":[236],"regulatory":[237],"actions":[238],"limit":[240],"hookah-related":[241,250],"toxicants":[244],"including":[245],"initiate":[247],"labeling":[248],"products,":[251],"include":[253],"clean":[257],"air":[259],"legislation.":[260],"Cancer":[261],"Epidemiol":[262],"Biomarkers":[263],"Prev;":[264],"23(12);":[265],"2793\u2013809.":[266],"\u00a92014":[267],"AACR.":[268]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}