{"id":"https://openalex.org/W4361940800","doi":"https://doi.org/10.1158/1535-7163.22485687","title":"Supplementary Methods and Figure Legends from Sorafenib, a Multikinase Inhibitor, Enhances the Response of Melanoma to Regional Chemotherapy","display_name":"Supplementary Methods and Figure Legends from Sorafenib, a Multikinase Inhibitor, Enhances the Response of Melanoma to Regional Chemotherapy","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361940800","doi":"https://doi.org/10.1158/1535-7163.22485687"},"language":"en","primary_location":{"id":"doi:10.1158/1535-7163.22485687","doi":"https://doi.org/10.1158/1535-7163.22485687","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22485687","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1535-7163.22485687","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040672041","display_name":"Christina K. Augustine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina K. Augustine","raw_affiliation_strings":["Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058720181","display_name":"Hiroaki Toshimitsu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hiroaki Toshimitsu","raw_affiliation_strings":["Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023554560","display_name":"Sin\u2010Ho Jung","orcid":"https://orcid.org/0000-0002-1473-7236","observed_orcids":["https://orcid.org/0000-0002-1473-7236"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sin-Ho Jung","raw_affiliation_strings":["Biostatistics and Bioinformatics and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics and Bioinformatics and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017076359","display_name":"Patricia A. Zipfel","orcid":"https://orcid.org/0000-0001-7287-803X","observed_orcids":["https://orcid.org/0000-0001-7287-803X"]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia A. Zipfel","raw_affiliation_strings":["Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103484886","display_name":"Jin Sun Yoo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin S. Yoo","raw_affiliation_strings":["Departments of 1 Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102759373","display_name":"Yasunori Yoshimoto","orcid":"https://orcid.org/0000-0001-8413-2147","observed_orcids":["https://orcid.org/0000-0001-8413-2147"]},"institutions":[{"id":"https://openalex.org/I173915773","display_name":"Yamaguchi University","ror":"https://ror.org/03cxys317","country_code":"JP","type":"education","lineage":["https://openalex.org/I173915773"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasunori Yoshimoto","raw_affiliation_strings":["Department of Surgery II, Yamaguchi University School of Medicine, Yamaguchi, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery II, Yamaguchi University School of Medicine, Yamaguchi, Japan","institution_ids":["https://openalex.org/I173915773"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111697259","display_name":"M. Ang\u00e9lica Selim","orcid":"https://orcid.org/0000-0003-4208-7426","observed_orcids":["https://orcid.org/0000-0003-4208-7426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Angelica Selim","raw_affiliation_strings":["Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031675124","display_name":"James L. Burchette","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Burchette","raw_affiliation_strings":["Pathology,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050528758","display_name":"Georgia Marie Beasley","orcid":"https://orcid.org/0000-0001-6387-9030","observed_orcids":["https://orcid.org/0000-0001-6387-9030"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Georgia M. Beasley","raw_affiliation_strings":["Departments of 1 Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508206","display_name":"Nicole S. McMahon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole McMahon","raw_affiliation_strings":["Departments of 1 Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058405024","display_name":"James C. Padussis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Padussis","raw_affiliation_strings":["Departments of 1 Surgery,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of 1 Surgery,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112320058","display_name":"Scott Knowles Pruitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Scott K. Pruitt","raw_affiliation_strings":["Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and","institution_ids":["https://openalex.org/I4210139568"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004785534","display_name":"Francis Ali\u2010Osman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francis Ali-Osman","raw_affiliation_strings":["Surgical Sciences Duke University Medical Center,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Sciences Duke University Medical Center,","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015827608","display_name":"Douglas S. Tyler","orcid":"https://orcid.org/0000-0002-7434-846X","observed_orcids":["https://orcid.org/0000-0002-7434-846X"]},"institutions":[{"id":"https://openalex.org/I4210139568","display_name":"Durham VA Medical Center","ror":"https://ror.org/034adnw64","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210119589","https://openalex.org/I4210139568","https://openalex.org/I4210159720"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas S. Tyler","raw_affiliation_strings":["Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Surgical Service, Durham Veteran's Affairs Medical Center, Durham, North Carolina and","institution_ids":["https://openalex.org/I4210139568"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.5967000126838684,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.3659999966621399,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sorafenib","display_name":"sorafenib","score":1.0},{"id":"https://openalex.org/keywords/multikinase-inhibitor","display_name":"multikinase inhibitor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/regional-chemotherapy","display_name":"regional chemotherapy","score":0.9879999756813049},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.5249999761581421},{"id":"https://openalex.org/keywords/drug-synergy","display_name":"drug synergy","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C2778695046","wikidata":"https://www.wikidata.org/wiki/Q421136","display_name":"Sorafenib","level":3,"score":0.8866719007492065},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6080875396728516},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6066559553146362},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5167362093925476},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4327564537525177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.351461261510849},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33640599250793457},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.24193373322486877},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1535-7163.22485687","doi":"https://doi.org/10.1158/1535-7163.22485687","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22485687","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1535-7163.22485687.v1","doi":"https://doi.org/10.1158/1535-7163.22485687.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22485687.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Methods_and_Figure_Legends_from_Sorafenib_a_Multikinase_Inhibitor_Enhances_the_Response_of_Melanoma_to_Regional_Chemotherapy/22485687/1/files/39937248.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22485687","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Methods_and_Figure_Legends_from_Sorafenib_a_Multikinase_Inhibitor_Enhances_the_Response_of_Melanoma_to_Regional_Chemotherapy/22485687","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1535-7163.22485687","doi":"https://doi.org/10.1158/1535-7163.22485687","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1535-7163.22485687","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8348000049591064,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361940800.pdf","grobid_xml":"https://content.openalex.org/works/W4361940800.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2096392545","https://openalex.org/W4361954516","https://openalex.org/W6958978229","https://openalex.org/W2094960662","https://openalex.org/W7808089","https://openalex.org/W2066635600","https://openalex.org/W2002812414","https://openalex.org/W2140814943","https://openalex.org/W2148171430","https://openalex.org/W4361961206"],"abstract_inverted_index":{"Supplementary":[0],"Methods":[1],"and":[2],"Figure":[3],"Legends":[4],"from":[5],"Sorafenib,":[6],"a":[7],"Multikinase":[8],"Inhibitor,":[9],"Enhances":[10],"the":[11],"Response":[12],"of":[13],"Melanoma":[14],"to":[15],"Regional":[16],"Chemotherapy":[17]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}