{"id":"https://openalex.org/W4361938176","doi":"https://doi.org/10.1158/1078-0432.22478319.v1","title":"Table S4 from Phase I Study of the Efficacy and Safety of Ramucirumab in Combination with Osimertinib in Advanced T790M-positive EGFR-mutant Non\u2013small Cell Lung Cancer","display_name":"Table S4 from Phase I Study of the Efficacy and Safety of Ramucirumab in Combination with Osimertinib in Advanced T790M-positive EGFR-mutant Non\u2013small Cell Lung Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361938176","doi":"https://doi.org/10.1158/1078-0432.22478319.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22478319.v1","doi":"https://doi.org/10.1158/1078-0432.22478319.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22478319.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22478319.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014837967","display_name":"Helena Alexandra Yu","orcid":"https://orcid.org/0000-0002-0377-9510","observed_orcids":["https://orcid.org/0000-0002-0377-9510"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Helena A. Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052765751","display_name":"Luis G Paz-Ares","orcid":"https://orcid.org/0000-0002-1947-3364","observed_orcids":["https://orcid.org/0000-0002-1947-3364"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luis G. Paz-Ares","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055074037","display_name":"James Chih\u2010Hsin Yang","orcid":"https://orcid.org/0000-0002-5586-5138","observed_orcids":["https://orcid.org/0000-0002-5586-5138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Chih-Hsin Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005962138","display_name":"Ki Hyeong Lee","orcid":"https://orcid.org/0000-0002-7830-5950","observed_orcids":["https://orcid.org/0000-0002-7830-5950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ki Hyeong Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7830-5950","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050766137","display_name":"Pilar Garrido","orcid":"https://orcid.org/0000-0002-5899-6125","observed_orcids":["https://orcid.org/0000-0002-5899-6125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pilar Garrido","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5899-6125","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030107272","display_name":"Keunchil Park","orcid":"https://orcid.org/0000-0002-4846-7449","observed_orcids":["https://orcid.org/0000-0002-4846-7449"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keunchil Park","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-4846-7449","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005188570","display_name":"Joo-Hang Kim","orcid":"https://orcid.org/0000-0003-0408-8997","observed_orcids":["https://orcid.org/0000-0003-0408-8997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joo-Hang Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005962138","display_name":"Ki Hyeong Lee","orcid":"https://orcid.org/0000-0002-7830-5950","observed_orcids":["https://orcid.org/0000-0002-7830-5950"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dae Ho Lee","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-7830-5950","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112368424","display_name":"Huzhang Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huzhang Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021147423","display_name":"Sameera R. Wijayawardana","orcid":"https://orcid.org/0000-0002-5187-167X","observed_orcids":["https://orcid.org/0000-0002-5187-167X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sameera R. Wijayawardana","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100663333","display_name":"Ling Gao","orcid":"https://orcid.org/0000-0002-1704-6545","observed_orcids":["https://orcid.org/0000-0002-1704-6545"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ling Gao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038009127","display_name":"Rebecca R. Hozak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rebecca R. Hozak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028800670","display_name":"Bo H. Chao","orcid":"https://orcid.org/0000-0003-2335-5579","observed_orcids":["https://orcid.org/0000-0003-2335-5579"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bo H. Chao","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-2335-5579","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028596081","display_name":"David Planchard","orcid":"https://orcid.org/0000-0002-1565-8310","observed_orcids":["https://orcid.org/0000-0002-1565-8310"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Planchard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ramucirumab","display_name":"ramucirumab","score":1.0},{"id":"https://openalex.org/keywords/osimertinib","display_name":"osimertinib","score":1.0},{"id":"https://openalex.org/keywords/egfr-t790m-mutation","display_name":"T790M mutation","score":0.8009999990463257},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.9509999752044678},{"id":"https://openalex.org/keywords/advanced-non-small-cell-lung-cancer","display_name":"advanced non-small cell lung cancer","score":0.8220000267028809},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6159999966621399},{"id":"https://openalex.org/keywords/death","display_name":"death","score":0.4729999899864197},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6209999918937683}],"concepts":[{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.9620957970619202},{"id":"https://openalex.org/C2777930144","wikidata":"https://www.wikidata.org/wiki/Q25100112","display_name":"T790M","level":5,"score":0.8799762725830078},{"id":"https://openalex.org/C2779551604","wikidata":"https://www.wikidata.org/wiki/Q7290345","display_name":"Ramucirumab","level":3,"score":0.48808562755584717},{"id":"https://openalex.org/C3018359032","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Safety profile","level":3,"score":0.479879766702652},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.46836650371551514},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.46759694814682007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4568941593170166},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.4473683536052704},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40591710805892944},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3755631148815155},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3412104845046997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2566511034965515},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.17179930210113525},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16465270519256592},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1622885763645172},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.09910804033279419},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0987081527709961},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.09748682379722595},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C2780580887","wikidata":"https://www.wikidata.org/wiki/Q417824","display_name":"Gefitinib","level":4,"score":0.0},{"id":"https://openalex.org/C2778087573","wikidata":"https://www.wikidata.org/wiki/Q418369","display_name":"Erlotinib","level":4,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22478319.v1","doi":"https://doi.org/10.1158/1078-0432.22478319.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22478319.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22478319","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Table_S4_from_Phase_I_Study_of_the_Efficacy_and_Safety_of_Ramucirumab_in_Combination_with_Osimertinib_in_Advanced_T790M-positive_i_EGFR_i_-mutant_Non_small_Cell_Lung_Cancer/22478319","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22478319.v1","doi":"https://doi.org/10.1158/1078-0432.22478319.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22478319.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7200000286102295}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361889170","https://openalex.org/W4361889246","https://openalex.org/W4361938163","https://openalex.org/W4361889153","https://openalex.org/W4361938219","https://openalex.org/W4361889128","https://openalex.org/W4361938187","https://openalex.org/W3091987693","https://openalex.org/W2890244190","https://openalex.org/W4361946733"],"abstract_inverted_index":{"Summary":[0],"of":[1,6],"Death":[2],"and":[3],"Adverse":[4],"Events":[5],"Special":[7],"Interest":[8]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}