{"id":"https://openalex.org/W4361936360","doi":"https://doi.org/10.1158/1078-0432.22475030","title":"Supplementary data from Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability","display_name":"Supplementary data from Paclitaxel Sensitivity of Ovarian Cancer Can be Enhanced by Knocking Down Pairs of Kinases that Regulate MAP4 Phosphorylation and Microtubule Stability","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361936360","doi":"https://doi.org/10.1158/1078-0432.22475030"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22475030","doi":"https://doi.org/10.1158/1078-0432.22475030","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22475030","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.22475030","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110967194","display_name":"Hailing Yang","orcid":"https://orcid.org/0009-0003-7744-1146","observed_orcids":["https://orcid.org/0009-0003-7744-1146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hailing Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111381332","display_name":"Weiqun Mao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Weiqun Mao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010129570","display_name":"Cristian Rodriguez\u2010Aguayo","orcid":"https://orcid.org/0000-0002-7880-7723","observed_orcids":["https://orcid.org/0000-0002-7880-7723"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cristian Rodriguez-Aguayo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042760638","display_name":"Lingegowda Selanere Mangala","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingegowda S. Mangala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016964651","display_name":"Geoffrey A. Bartholomeusz","orcid":"https://orcid.org/0000-0002-4622-4195","observed_orcids":["https://orcid.org/0000-0002-4622-4195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Geoffrey Bartholomeusz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069099847","display_name":"LaKesla R. Iles","orcid":"https://orcid.org/0000-0001-6992-7910","observed_orcids":["https://orcid.org/0000-0001-6992-7910"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lakesla R. Iles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104069731","display_name":"Nicholas B. Jennings","orcid":"https://orcid.org/0000-0003-0357-2920","observed_orcids":["https://orcid.org/0000-0003-0357-2920"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicholas B. Jennings","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011464110","display_name":"Ahmed A. Ahmed","orcid":"https://orcid.org/0000-0001-6509-2581","observed_orcids":["https://orcid.org/0000-0001-6509-2581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ahmed Ashour Ahmed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100640276","display_name":"Anil K. Sood","orcid":"https://orcid.org/0000-0002-5415-9901","observed_orcids":["https://orcid.org/0000-0002-5415-9901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anil K. Sood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023542865","display_name":"Gabriel Lopez\u2010Berestein","orcid":"https://orcid.org/0000-0002-0366-0720","observed_orcids":["https://orcid.org/0000-0002-0366-0720"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gabriel Lopez-Berestein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088086867","display_name":"Zhen L\u00fc","orcid":"https://orcid.org/0000-0002-9596-0148","observed_orcids":["https://orcid.org/0000-0002-9596-0148"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhen Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067595997","display_name":"Robert C. Bast","orcid":"https://orcid.org/0000-0003-4621-8462","observed_orcids":["https://orcid.org/0000-0003-4621-8462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert C. Bast","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.038100000470876694,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.023099999874830246,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel-sensitivity","display_name":"paclitaxel sensitivity","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/microtubule-stability","display_name":"microtubule stability","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sirna-screening","display_name":"siRNA screening","score":0.6119999885559082},{"id":"https://openalex.org/keywords/ikkbeta","display_name":"IKK\u03b2","score":0.9599999785423279},{"id":"https://openalex.org/keywords/stk39","display_name":"STK39","score":0.9589999914169312},{"id":"https://openalex.org/keywords/tbk1","display_name":"TBK1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p38-mapk-signaling","display_name":"p38 MAPK signaling","score":0.906000018119812},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.4429999887943268}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.8573381900787354},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.5960093140602112},{"id":"https://openalex.org/C20418707","wikidata":"https://www.wikidata.org/wiki/Q189933","display_name":"Microtubule","level":2,"score":0.574709951877594},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.5462498068809509},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.5188739895820618},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.515052318572998},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5049465298652649},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.4586368501186371},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.43974852561950684},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.42594611644744873},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4240097105503082},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37477439641952515},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3581077456474304},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.33254849910736084},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2841874659061432},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2502617835998535},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1875053346157074},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14390239119529724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07600000500679016},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22475030","doi":"https://doi.org/10.1158/1078-0432.22475030","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22475030","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22475030.v1","doi":"https://doi.org/10.1158/1078-0432.22475030.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22475030.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_data_from_Paclitaxel_Sensitivity_of_Ovarian_Cancer_Can_be_Enhanced_by_Knocking_Down_Pairs_of_Kinases_that_Regulate_MAP4_Phosphorylation_and_Microtubule_Stability/22475030/1/files/39926531.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22475030","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_data_from_Paclitaxel_Sensitivity_of_Ovarian_Cancer_Can_be_Enhanced_by_Knocking_Down_Pairs_of_Kinases_that_Regulate_MAP4_Phosphorylation_and_Microtubule_Stability/22475030","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22475030","doi":"https://doi.org/10.1158/1078-0432.22475030","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22475030","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361936360.pdf","grobid_xml":"https://content.openalex.org/works/W4361936360.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361953141","https://openalex.org/W2810769393","https://openalex.org/W2480844546","https://openalex.org/W2325565814","https://openalex.org/W4361241364","https://openalex.org/W2079268495","https://openalex.org/W2091739733","https://openalex.org/W1825010762","https://openalex.org/W4251566988","https://openalex.org/W2137130657"],"abstract_inverted_index":{"Table":[0,7,13,16,24,32,42,56],"S1.":[1,62],"Cell":[2],"lines":[3],"and":[4,30,114,139,143,155],"culture":[5],"media":[6],"S2.":[8,72],"GE":[9],"Dharmacon":[10],"siRNA":[11,18,48,67,154],"catalogues":[12],"S3.":[14,81],"Primers":[15],"S4.":[17,98],"transfection":[19],"conditions":[20],"for":[21,27],"custom":[22],"screens":[23],"S5.":[25,131],"Antibodies":[26],"Western":[28],"blot":[29],"immunohistochemistry":[31],"S6.":[33,150],"Paclitaxel":[34,44],"sensitivity":[35,45,134],"in":[36,50,77],"12":[37],"ovarian":[38,52],"cancer":[39,53],"cell":[40,54],"lines.":[41,55],"S7.":[43],"of":[46,64,84,101,120,137],"two":[47],"combination":[49],"six":[51],"S8.":[57],"TMA":[58],"patient":[59],"information":[60],"Figure":[61,71,80,97,130,149],"Effects":[63],"single":[65],"kinase":[66],"on":[68],"microtubule":[69,95,112,116],"stability.":[70,96],"Knockdown":[73],"efficiency":[74],"was":[75],"examined":[76],"SKOv3ip":[78],"cells.":[79],"Sequential":[82,99],"treatment":[83,100],"siIKBKB":[85,102],"followed":[86,91,103,108],"by":[87,92,104,109,118,135],"siSTK39":[88,105],"or":[89,106,122,141],"siEDN2":[90,107],"siTBK1":[93,110],"increases":[94,111],"stability":[113,117],"increasing":[115],"depletion":[119,136],"IKBKB/STK39":[121],"EDN2/TBK1":[123],"is":[124,145],"dependent":[125,146],"upon":[126,147],"p38-mdiated":[127],"phosphorylation":[128],"MAP4.":[129,148],"Increasing":[132],"paclitaxel":[133,156],"IKBKB":[138],"TK39":[140],"EDN2":[142],"TBK1":[144],"Mice":[151],"tolerate":[152],"the":[153],"treatment.":[157]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}