{"id":"https://openalex.org/W4361936156","doi":"https://doi.org/10.1158/1078-0432.22473645.v1","title":"Figure S1 from Functional Properties of KIT Mutations Are Associated with Differential Clinical Outcomes and Response to Targeted Therapeutics in CBF Acute Myeloid Leukemia","display_name":"Figure S1 from Functional Properties of KIT Mutations Are Associated with Differential Clinical Outcomes and Response to Targeted Therapeutics in CBF Acute Myeloid Leukemia","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361936156","doi":"https://doi.org/10.1158/1078-0432.22473645.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22473645.v1","doi":"https://doi.org/10.1158/1078-0432.22473645.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22473645.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22473645.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5081153366","display_name":"Katherine Tarlock","orcid":"https://orcid.org/0000-0001-9717-2973","observed_orcids":["https://orcid.org/0000-0001-9717-2973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine Tarlock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066861312","display_name":"Todd A. Alonzo","orcid":"https://orcid.org/0000-0002-6772-6581","observed_orcids":["https://orcid.org/0000-0002-6772-6581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Todd A. Alonzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411056","display_name":"Yi\u2010Cheng Wang","orcid":"https://orcid.org/0000-0003-2432-5128","observed_orcids":["https://orcid.org/0000-0003-2432-5128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yi-Cheng Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021003209","display_name":"Robert B. Gerbing","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert B. Gerbing","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017522276","display_name":"Rhonda E. Ries","orcid":"https://orcid.org/0000-0002-3702-7923","observed_orcids":["https://orcid.org/0000-0002-3702-7923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rhonda Ries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063746286","display_name":"Michael R. Loken","orcid":"https://orcid.org/0000-0002-0335-9065","observed_orcids":["https://orcid.org/0000-0002-0335-9065"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael R. Loken","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101776814","display_name":"Laura M. Pardo","orcid":"https://orcid.org/0000-0001-7031-9795","observed_orcids":["https://orcid.org/0000-0001-7031-9795"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura Pardo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109739554","display_name":"Tiffany Hylkema","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tiffany Hylkema","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061108762","display_name":"Jason Joaquin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jason Joaquin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069897683","display_name":"Leela Sarukkai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leela Sarukkai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012776569","display_name":"Susana Catalina Raimondi","orcid":"https://orcid.org/0000-0001-8155-3018","observed_orcids":["https://orcid.org/0000-0001-8155-3018"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susana C. Raimondi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035790918","display_name":"Betsy A Hirsch","orcid":"https://orcid.org/0000-0003-0162-6905","observed_orcids":["https://orcid.org/0000-0003-0162-6905"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Betsy Hirsch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086900250","display_name":"Lillian Sung","orcid":"https://orcid.org/0000-0003-0951-3091","observed_orcids":["https://orcid.org/0000-0003-0951-3091"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lillian Sung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037359116","display_name":"Richard Aplenc","orcid":"https://orcid.org/0000-0001-7482-5644","observed_orcids":["https://orcid.org/0000-0001-7482-5644"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard Aplenc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050992845","display_name":"Irwin D. Bernstein","orcid":"https://orcid.org/0000-0003-0795-3392","observed_orcids":["https://orcid.org/0000-0003-0795-3392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irwin Bernstein","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073322914","display_name":"Alan S. Gamis","orcid":"https://orcid.org/0000-0003-1513-2893","observed_orcids":["https://orcid.org/0000-0003-1513-2893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan S. Gamis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049490094","display_name":"Soheil Meshinchi","orcid":"https://orcid.org/0000-0002-6276-4423","observed_orcids":["https://orcid.org/0000-0002-6276-4423"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soheil Meshinchi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5069036596","display_name":"Jessica Anne Pollard","orcid":"https://orcid.org/0000-0001-7307-9010","observed_orcids":["https://orcid.org/0000-0001-7307-9010"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jessica A. Pollard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11215","display_name":"Chronic Myeloid Leukemia Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kit-mutations","display_name":"KIT mutations","score":0.9549999833106995},{"id":"https://openalex.org/keywords/inv-16","display_name":"inv(16)","score":0.9359999895095825},{"id":"https://openalex.org/keywords/clinical-outcomes","display_name":"clinical outcomes","score":0.8410000205039978},{"id":"https://openalex.org/keywords/targeted-therapy-response","display_name":"targeted therapy response","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.5828024744987488},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.5094967484474182},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5043307542800903},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5016834735870361},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.48487481474876404},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40378129482269287},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37970852851867676},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.352492094039917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.34228700399398804},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.29949742555618286},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19404053688049316}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22473645.v1","doi":"https://doi.org/10.1158/1078-0432.22473645.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22473645.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22473645.v1","doi":"https://doi.org/10.1158/1078-0432.22473645.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22473645.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2035482751","https://openalex.org/W2375707865","https://openalex.org/W2990397977","https://openalex.org/W4236316986","https://openalex.org/W1570595782","https://openalex.org/W2774908952","https://openalex.org/W2363321557","https://openalex.org/W4238180331","https://openalex.org/W2117487081","https://openalex.org/W2012639655"],"abstract_inverted_index":{"Supplemental":[0],"Figure":[1],"1.":[2],"(A)":[3],"KIT":[4],"mutational":[5],"status":[6],"of":[7,12,26,39],"the":[8,16],"cohort;":[9],"(B)":[10,21],"Prevalence":[11],"CBF":[13],"subtype":[14],"among":[15],"E8":[17,23],"and":[18,30,43],"E17":[19,36],"mutations.":[20],"Among":[22,35],"mutations,":[24,37],"54%":[25],"patients":[27,40],"were":[28,32,41,45],"inv(16)":[29,42],"46%":[31],"t(8;21).":[33,46],"(C)":[34],"37%":[38],"63%":[44]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}