{"id":"https://openalex.org/W4361935178","doi":"https://doi.org/10.1158/1078-0432.22471901","title":"Supplementary Figures 1-12 from HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma","display_name":"Supplementary Figures 1-12 from HDAC Inhibition Enhances the In Vivo Efficacy of MEK Inhibitor Therapy in Uveal Melanoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361935178","doi":"https://doi.org/10.1158/1078-0432.22471901"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22471901","doi":"https://doi.org/10.1158/1078-0432.22471901","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22471901","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22471901","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078040855","display_name":"Fernanda Fai\u00e3o\u2010Flores","orcid":"https://orcid.org/0000-0003-3449-9930","observed_orcids":["https://orcid.org/0000-0003-3449-9930"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fernanda Fai\u00e3o-Flores","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013287959","display_name":"Michael F. Emmons","orcid":"https://orcid.org/0000-0002-0008-8335","observed_orcids":["https://orcid.org/0000-0002-0008-8335"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael F. Emmons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070524317","display_name":"Michael A. Durante","orcid":"https://orcid.org/0000-0003-3137-6847","observed_orcids":["https://orcid.org/0000-0003-3137-6847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael A. Durante","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3137-6847","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006968359","display_name":"Fumi Kinose","orcid":"https://orcid.org/0009-0009-8172-8645","observed_orcids":["https://orcid.org/0009-0009-8172-8645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fumi Kinose","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084676486","display_name":"Biswarup Saha","orcid":"https://orcid.org/0000-0003-2797-7308","observed_orcids":["https://orcid.org/0000-0003-2797-7308"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Biswarup Saha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046520540","display_name":"Bin Fang","orcid":"https://orcid.org/0000-0003-1955-6626","observed_orcids":["https://orcid.org/0000-0003-1955-6626"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bin Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002876951","display_name":"John M. Koomen","orcid":"https://orcid.org/0000-0002-3818-1762","observed_orcids":["https://orcid.org/0000-0002-3818-1762"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Koomen","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3818-1762","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028727643","display_name":"Srikumar Chellappan","orcid":"https://orcid.org/0000-0003-1216-2966","observed_orcids":["https://orcid.org/0000-0003-1216-2966"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Srikumar P. Chellappan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-1216-2966","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000915729","display_name":"Silvya Stuchi Maria\u2013Engler","orcid":"https://orcid.org/0000-0003-4771-6041","observed_orcids":["https://orcid.org/0000-0003-4771-6041"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silvya Stuchi Maria-Engler","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012452779","display_name":"Uwe Rix","orcid":"https://orcid.org/0000-0002-8242-2770","observed_orcids":["https://orcid.org/0000-0002-8242-2770"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Uwe Rix","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034992183","display_name":"Jonathan D. Licht","orcid":"https://orcid.org/0000-0002-3942-1369","observed_orcids":["https://orcid.org/0000-0002-3942-1369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan D. Licht","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-3942-1369","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077374286","display_name":"J. William Harbour","orcid":"https://orcid.org/0000-0002-1104-9809","observed_orcids":["https://orcid.org/0000-0002-1104-9809"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. William Harbour","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1104-9809","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059758317","display_name":"Keiran S.M. Smalley","orcid":"https://orcid.org/0000-0003-1089-9307","observed_orcids":["https://orcid.org/0000-0003-1089-9307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keiran S.M. Smalley","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9154999852180481,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.04529999941587448,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.008100000210106373,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":0.9750000238418579},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8659999966621399},{"id":"https://openalex.org/keywords/mek-inhibitors","display_name":"MEK inhibitors","score":0.9660000205039978},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9760000109672546},{"id":"https://openalex.org/keywords/protein-acetylation","display_name":"protein acetylation","score":0.8949999809265137},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.9459999799728394},{"id":"https://openalex.org/keywords/uveal-melanocytes","display_name":"uveal melanocytes","score":0.8050000071525574},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.7739999890327454},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.746999979019165}],"concepts":[{"id":"https://openalex.org/C2781249067","wikidata":"https://www.wikidata.org/wiki/Q17142288","display_name":"MEK inhibitor","level":4,"score":0.7873467206954956},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.7776323556900024},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.586646318435669},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5492923855781555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46460622549057007},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.46011027693748474},{"id":"https://openalex.org/C2776999253","wikidata":"https://www.wikidata.org/wiki/Q1304270","display_name":"Combination therapy","level":2,"score":0.4151473045349121},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.3949263095855713},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.357441782951355},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.22396960854530334},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.22337111830711365},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.21959874033927917},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06773504614830017}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22471901","doi":"https://doi.org/10.1158/1078-0432.22471901","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22471901","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22471901.v1","doi":"https://doi.org/10.1158/1078-0432.22471901.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22471901.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39923384","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22471901","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_1-12_from_HDAC_Inhibition_Enhances_the_i_In_Vivo_i_Efficacy_of_MEK_Inhibitor_Therapy_in_Uveal_Melanoma/22471901","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22471901","doi":"https://doi.org/10.1158/1078-0432.22471901","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22471901","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361935178.pdf","grobid_xml":"https://content.openalex.org/works/W4361935178.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2949451543","https://openalex.org/W4361946687","https://openalex.org/W4243566932","https://openalex.org/W2810967725","https://openalex.org/W4220760971","https://openalex.org/W2989583406","https://openalex.org/W1795044920","https://openalex.org/W4282961418","https://openalex.org/W2927336270","https://openalex.org/W2024640232"],"abstract_inverted_index":{"Supplemental":[0,17,33,48,60,77,95,108,121,137,154,159],"Figure":[1,18,34,49,61,78,96,109,122,138,155,160],"1:":[2],"Gene":[3],"ontology":[4],"network":[5],"analysis":[6],"of":[7,24,57,91,102,113,142,148],"uveal":[8,74,93,105,133],"melanoma":[9,75,106,134],"cells":[10],"following":[11],"MEKi":[12],"treatment":[13,118],"(24h)":[14],"and":[15,30,82],"ABPP.":[16],"2:":[19],"ET-3":[20,103],"increases":[21],"nuclear":[22],"accumulation":[23],"YAP":[25,40],"in":[26,43,69,73,130],"92.1,":[27],"Mel270,":[28],"MP41":[29,149],"OMM1":[31],"cells.":[32,47,76,107],"3:":[35],"ET-1":[36],"does":[37],"not":[38,87],"induce":[39],"reporter":[41],"activity":[42],"92.1":[44,132],"or":[45],"Mel270":[46],"4:":[50],"HDAC":[51],"inhibitors":[52],"increase":[53,68],"the":[54,83,89,131],"cytotoxic":[55],"effects":[56],"MEK":[58,63],"inhibition.":[59],"5:":[62],"inhibition":[64],"leads":[65],"to":[66],"an":[67],"global":[70],"protein":[71],"acetylation":[72],"6:":[79],"MEKi,":[80],"HDACi":[81,98],"MEKi-HDACi":[84],"combination":[85,126],"do":[86],"affect":[88],"survival":[90],"primary":[92],"melanocytes.":[94],"7:":[97],"suppresses":[99],"MEKi-induced":[100],"release":[101],"from":[104],"8:":[110],"Negative":[111],"modulation":[112],"PI3K-AKT":[114],"pathway":[115],"by":[116,150],"combinatory":[117],"with":[119],"MEKi+HDACi.":[120],"9:":[123],"The":[124],"MEK-HDACi":[125],"delivers":[127],"durable":[128],"responses":[129],"xenograft":[135],"model.":[136],"10:":[139],"Macroscopic":[140],"findings":[141],"liver":[143],"tumor":[144],"formation":[145],"after":[146],"inoculation":[147],"tail":[151],"vein":[152],"injection.":[153],"11:":[156],"Uncropped":[157],"blots":[158],"12:":[161],"Flow":[162],"cytometry":[163],"plots":[164]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
