{"id":"https://openalex.org/W4361933150","doi":"https://doi.org/10.1158/1078-0432.22469823","title":"Supplemental Tables and Figures from Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma","display_name":"Supplemental Tables and Figures from Comparison of Biomarker Assays for EGFR: Implications for Precision Medicine in Patients with Glioblastoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361933150","doi":"https://doi.org/10.1158/1078-0432.22469823"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22469823","doi":"https://doi.org/10.1158/1078-0432.22469823","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22469823","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22469823","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057541817","display_name":"Andrew B. Lassman","orcid":"https://orcid.org/0000-0001-7386-9928","observed_orcids":["https://orcid.org/0000-0001-7386-9928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew B. Lassman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046267092","display_name":"Lisa A. Roberts-Rapp","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Roberts-Rapp","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111358282","display_name":"\u0418\u0440\u0438\u043d\u0430 \u0421\u043e\u043a\u043e\u043b\u043e\u0432\u0430","orcid":"https://orcid.org/0000-0002-3659-7086","observed_orcids":["https://orcid.org/0000-0002-3659-7086"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Irina Sokolova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101198559","display_name":"Minghao Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Minghao Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031259595","display_name":"Ekaterina V. Pestova","orcid":"https://orcid.org/0000-0001-8200-2621","observed_orcids":["https://orcid.org/0000-0001-8200-2621"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ekaterina Pestova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108691500","display_name":"Rupinder K. Kular","orcid":"https://orcid.org/0009-0000-9840-6508","observed_orcids":["https://orcid.org/0009-0000-9840-6508"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rupinder Kular","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019051973","display_name":"Carolyn Mullen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carolyn Mullen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100569813","display_name":"Zheng Zha","orcid":"https://orcid.org/0009-0000-8489-7457","observed_orcids":["https://orcid.org/0009-0000-8489-7457"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zheng Zha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Xin Lu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Lu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079146812","display_name":"Erica J. Gomez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erica Gomez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036645151","display_name":"Anahita Bhathena","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anahita Bhathena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059093147","display_name":"David Maag","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Maag","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091750059","display_name":"Priya Kumthekar","orcid":"https://orcid.org/0000-0001-5923-0677","observed_orcids":["https://orcid.org/0000-0001-5923-0677"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Priya Kumthekar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010378038","display_name":"Hui Kong Gan","orcid":"https://orcid.org/0000-0001-7319-8546","observed_orcids":["https://orcid.org/0000-0001-7319-8546"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui K. Gan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7319-8546","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078312966","display_name":"Andrew Mark Scott","orcid":"https://orcid.org/0000-0002-6656-295X","observed_orcids":["https://orcid.org/0000-0002-6656-295X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew M. Scott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Guseva","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Guseva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015092618","display_name":"Kyle D. Holen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kyle D. Holen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033578335","display_name":"Peter J. Ansell","orcid":"https://orcid.org/0000-0002-4088-2840","observed_orcids":["https://orcid.org/0000-0002-4088-2840"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter J. Ansell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010891460","display_name":"Martin J. van den Bent","orcid":"https://orcid.org/0000-0001-5710-5127","observed_orcids":["https://orcid.org/0000-0001-5710-5127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martin J. van den Bent","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-5710-5127","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.961899995803833,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.01889999955892563,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.008299999870359898,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/egfr","display_name":"EGFR","score":0.9779999852180481},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/egfr-amplification","display_name":"EGFR amplification","score":0.859000027179718},{"id":"https://openalex.org/keywords/egfr-mrna-expression","display_name":"EGFR mRNA expression","score":0.921999990940094},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.8059999942779541},{"id":"https://openalex.org/keywords/whole-exome-sequencing","display_name":"exome sequencing","score":0.8420000076293945},{"id":"https://openalex.org/keywords/rt-pcr","display_name":"RT-PCR","score":0.7940000295639038},{"id":"https://openalex.org/keywords/rna-sequencing","display_name":"RNA sequencing","score":0.7950000166893005},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.9860000014305115},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"precision medicine","score":0.9399999976158142}],"concepts":[{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.8821173906326294},{"id":"https://openalex.org/C2781303241","wikidata":"https://www.wikidata.org/wiki/Q17165041","display_name":"Polysomy","level":5,"score":0.7086614966392517},{"id":"https://openalex.org/C2909208804","wikidata":"https://www.wikidata.org/wiki/Q127282","display_name":"Fish <Actinopterygii>","level":2,"score":0.6404184699058533},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44241324067115784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3628265857696533},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35727930068969727},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3526586592197418},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3372958302497864},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2536894381046295},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2489699423313141},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21737739443778992},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.0},{"id":"https://openalex.org/C505870484","wikidata":"https://www.wikidata.org/wiki/Q180538","display_name":"Fishery","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22469823","doi":"https://doi.org/10.1158/1078-0432.22469823","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22469823","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22469823.v1","doi":"https://doi.org/10.1158/1078-0432.22469823.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22469823.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22469823","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplemental_Tables_and_Figures_from_Comparison_of_Biomarker_Assays_for_i_EGFR_i_Implications_for_Precision_Medicine_in_Patients_with_Glioblastoma/22469823","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22469823","doi":"https://doi.org/10.1158/1078-0432.22469823","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22469823","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8560000061988831}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2916215499","https://openalex.org/W4361953085","https://openalex.org/W4409782437","https://openalex.org/W2324431858","https://openalex.org/W2608516045","https://openalex.org/W2767639811","https://openalex.org/W1976678052","https://openalex.org/W2767539952","https://openalex.org/W2767423922","https://openalex.org/W6920581853"],"abstract_inverted_index":{"Supplementary":[0,9,17,26,35,44,57,66,78,91],"Table":[1,10,18,27,36],"S2.":[2,59],"Concordance":[3,20,29,38],"of":[4,21,30,39],"FISH":[5,22,31,40,60],"and":[6,23,32,41,96],"WES":[7],"results.":[8,25,34,43],"S3.":[11,68],"Point":[12,81],"mutations":[13,82],"identified":[14,83],"in":[15,54,64,84,88],"EGFR.":[16],"S4.":[19,80],"RT-PCR":[24],"S5.":[28,93],"RNAseq":[33],"S6.":[37],"IHC":[42],"Figure":[45,58,67,79,92],"S1.":[46],"Venn":[47],"diagram":[48],"showing":[49],"overlap":[50],"among":[51],"EGFR":[52,62,69,76,86,94],"assays":[53],"206":[55],"GBMs.":[56],"for":[61],"amplification":[63,95],"GBM.":[65],"polysomy":[70],"is":[71],"not":[72],"associated":[73],"with":[74],"increased":[75],"expression.":[77],"the":[85],"gene":[87],"patient":[89],"samples.":[90],"mRNA":[97],"expression":[98],"are":[99],"strongly":[100],"associated.":[101]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}