{"id":"https://openalex.org/W4361932948","doi":"https://doi.org/10.1158/1078-0432.22469646","title":"S2 from Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model","display_name":"S2 from Enhanced Intratumoral Delivery of SN38 as a Tocopherol Oxyacetate Prodrug Using Nanoparticles in a Neuroblastoma Xenograft Model","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361932948","doi":"https://doi.org/10.1158/1078-0432.22469646"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22469646","doi":"https://doi.org/10.1158/1078-0432.22469646","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22469646","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22469646","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052318072","display_name":"Ferro Nguyen","orcid":"https://orcid.org/0000-0001-6640-8445","observed_orcids":["https://orcid.org/0000-0001-6640-8445"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ferro Nguyen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009569107","display_name":"Ivan S. Alferiev","orcid":"https://orcid.org/0000-0002-7849-750X","observed_orcids":["https://orcid.org/0000-0002-7849-750X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Alferiev","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102441904","display_name":"Peng Guan","orcid":"https://orcid.org/0009-0009-8655-3346","observed_orcids":["https://orcid.org/0009-0009-8655-3346"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peng Guan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050305140","display_name":"David T. Guerrero","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David T. Guerrero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002567610","display_name":"Venkatadri Kolla","orcid":"https://orcid.org/0000-0002-2385-3407","observed_orcids":["https://orcid.org/0000-0002-2385-3407"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Venkatadri Kolla","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067159899","display_name":"Ganesh S. Moorthy","orcid":"https://orcid.org/0000-0002-8779-6034","observed_orcids":["https://orcid.org/0000-0002-8779-6034"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ganesh S. Moorthy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055602430","display_name":"Michael Chorny","orcid":"https://orcid.org/0000-0002-8243-9089","observed_orcids":["https://orcid.org/0000-0002-8243-9089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Chorny","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5004950779","display_name":"Garrett M. Brodeur","orcid":"https://orcid.org/0000-0002-6721-122X","observed_orcids":["https://orcid.org/0000-0002-6721-122X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Garrett M. Brodeur","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.9340999722480774,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.023900000378489494,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sn-38","display_name":"SN-38","score":0.9580000042915344},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.6269999742507935},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9399999976158142},{"id":"https://openalex.org/keywords/intratumoral-delivery","display_name":"intratumoral drug delivery","score":0.9399999976158142},{"id":"https://openalex.org/keywords/ki-67","display_name":"Ki-67","score":0.8429999947547913},{"id":"https://openalex.org/keywords/tumor-cell-proliferation","display_name":"tumor cell proliferation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/xenograft-models","display_name":"xenograft models","score":0.6240000128746033},{"id":"https://openalex.org/keywords/cell-differentiation","display_name":"cell differentiation","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.7054761648178101},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.6925175189971924},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.490190327167511},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.4806841313838959},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3937655985355377},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3560647964477539},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31304311752319336},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28970223665237427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28148776292800903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16245576739311218},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.08008316159248352},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22469646","doi":"https://doi.org/10.1158/1078-0432.22469646","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22469646","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22469646.v1","doi":"https://doi.org/10.1158/1078-0432.22469646.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22469646.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22469646","doi":"https://doi.org/10.1158/1078-0432.22469646","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22469646","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361933187","https://openalex.org/W2792870535","https://openalex.org/W4361953699","https://openalex.org/W2050620942","https://openalex.org/W2338559033","https://openalex.org/W2522533631","https://openalex.org/W4210351961","https://openalex.org/W2053622985","https://openalex.org/W2137425495","https://openalex.org/W4286267992"],"abstract_inverted_index":{"Supp":[0],"Figure":[1,3],"S2":[2],"S2.":[4],"Ki-67":[5,11,27,30,47],"indices":[6],"of":[7,13,32],"tumor":[8,17,37],"samples.":[9],"A,":[10],"staining":[12,31],"a":[14,24,33,43],"CPT-11":[15],"retreated":[16,36],"showing":[18,38],"abundant":[19],"undifferentiated":[20],"NB":[21,40],"cells":[22,41],"and":[23,42],"high":[25],"(>30%)":[26],"index.":[28,48],"B,":[29],"SN38-TOA":[34],"NP":[35],"ganglion-like":[39],"very":[44],"low":[45],"(<1%)":[46]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
