{"id":"https://openalex.org/W4361930384","doi":"https://doi.org/10.1158/1078-0432.22466999.v1","title":"Figure S7 from Demethylation Therapy as a Targeted Treatment for Human Papillomavirus\u2013Associated Head and Neck Cancer","display_name":"Figure S7 from Demethylation Therapy as a Targeted Treatment for Human Papillomavirus\u2013Associated Head and Neck Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361930384","doi":"https://doi.org/10.1158/1078-0432.22466999.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22466999.v1","doi":"https://doi.org/10.1158/1078-0432.22466999.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22466999.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22466999.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110486859","display_name":"Asel Biktasova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Asel Biktasova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Hajek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Hajek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008376558","display_name":"Andrew Kelvin Sewell","orcid":"https://orcid.org/0000-0003-3194-3135","observed_orcids":["https://orcid.org/0000-0003-3194-3135"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Sewell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904654","display_name":"Cyril S. Gary","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cyril Gary","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074948162","display_name":"Gary Bellinger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gary Bellinger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061066852","display_name":"Hari Anant Deshpande","orcid":"https://orcid.org/0000-0003-0697-9355","observed_orcids":["https://orcid.org/0000-0003-0697-9355"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hari A. Deshpande","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078179040","display_name":"Aarti Khushal Bhatia","orcid":"https://orcid.org/0000-0002-0491-4454","observed_orcids":["https://orcid.org/0000-0002-0491-4454"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aarti Bhatia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023000705","display_name":"Barbara Ann Burtness","orcid":"https://orcid.org/0000-0003-4660-1859","observed_orcids":["https://orcid.org/0000-0003-4660-1859"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Burtness","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091901327","display_name":"Benjamin L. Judson","orcid":"https://orcid.org/0000-0002-0771-4220","observed_orcids":["https://orcid.org/0000-0002-0771-4220"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benjamin Judson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041429894","display_name":"Saral Mehra","orcid":"https://orcid.org/0000-0003-3109-7987","observed_orcids":["https://orcid.org/0000-0003-3109-7987"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saral Mehra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001660012","display_name":"Wendell Gray Yarbrough","orcid":"https://orcid.org/0000-0003-0855-6444","observed_orcids":["https://orcid.org/0000-0003-0855-6444"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wendell G. Yarbrough","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000300151","display_name":"Natalia Issaeva","orcid":"https://orcid.org/0000-0001-5483-6610","observed_orcids":["https://orcid.org/0000-0001-5483-6610"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Issaeva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.5493000149726868,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.3596000075340271,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10146","display_name":"Cervical Cancer and HPV Research","score":0.0471000000834465,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/demethylation-therapy","display_name":"demethylation therapy","score":0.9169999957084656},{"id":"https://openalex.org/keywords/human-papillomavirus","display_name":"human papillomavirus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/hpv-positive-head-and-neck-cancer","display_name":"HPV-associated head and neck cancer","score":0.9089999794960022},{"id":"https://openalex.org/keywords/mmp-1","display_name":"MMP-1","score":0.8009999990463257},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7620000243186951},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.7450000047683716}],"concepts":[{"id":"https://openalex.org/C129527566","wikidata":"https://www.wikidata.org/wiki/Q18029185","display_name":"MMP1","level":4,"score":0.6114775538444519},{"id":"https://openalex.org/C2994532551","wikidata":"https://www.wikidata.org/wiki/Q184627","display_name":"Human papillomavirus","level":2,"score":0.5760769248008728},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.5339941382408142},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4968915283679962},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.4908190667629242},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.47222116589546204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4367353618144989},{"id":"https://openalex.org/C202199734","wikidata":"https://www.wikidata.org/wiki/Q900386","display_name":"Demethylation","level":5,"score":0.41552799940109253},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4028703570365906},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3346385359764099},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3094896376132965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13833796977996826},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.09802737832069397},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.09314680099487305},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09281393885612488},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0872812271118164}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22466999.v1","doi":"https://doi.org/10.1158/1078-0432.22466999.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22466999.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22466999.v1","doi":"https://doi.org/10.1158/1078-0432.22466999.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22466999.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9789000153541565,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361886863","https://openalex.org/W4361886860","https://openalex.org/W4361929474","https://openalex.org/W4361886672","https://openalex.org/W2766141649","https://openalex.org/W4361886541","https://openalex.org/W4361952582","https://openalex.org/W2735027819","https://openalex.org/W4361929654","https://openalex.org/W4361929460"],"abstract_inverted_index":{"Fold":[0],"change":[1],"in":[2,5],"MMP1":[3],"expression":[4],"HPV-":[6],"cell":[7],"lines,":[8],"as":[9],"determined":[10],"by":[11],"qRT-PCR":[12]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-05T00:00:00"}