{"id":"https://openalex.org/W4361930331","doi":"https://doi.org/10.1158/1078-0432.22467551.v1","title":"Figure S1. Pathway-guided vaccine response predictions. from PI3K/Akt/mTOR Signaling and Plasma Membrane Proteins Are Implicated in Responsiveness to Adjuvant Dendritic Cell Vaccination for Metastatic Colorectal Cancer","display_name":"Figure S1. Pathway-guided vaccine response predictions. from PI3K/Akt/mTOR Signaling and Plasma Membrane Proteins Are Implicated in Responsiveness to Adjuvant Dendritic Cell Vaccination for Metastatic Colorectal Cancer","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361930331","doi":"https://doi.org/10.1158/1078-0432.22467551.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22467551.v1","doi":"https://doi.org/10.1158/1078-0432.22467551.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22467551.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22467551.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080344879","display_name":"David C. Qian","orcid":"https://orcid.org/0000-0002-8459-009X","observed_orcids":["https://orcid.org/0000-0002-8459-009X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David C. Qian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048114477","display_name":"Xiangjun Xiao","orcid":"https://orcid.org/0009-0006-5827-7661","observed_orcids":["https://orcid.org/0009-0006-5827-7661"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiangjun Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007160329","display_name":"Jinyoung Byun","orcid":"https://orcid.org/0000-0001-8579-1435","observed_orcids":["https://orcid.org/0000-0001-8579-1435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jinyoung Byun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001118529","display_name":"Arief Antonius Suriawinata","orcid":"https://orcid.org/0009-0007-1595-4332","observed_orcids":["https://orcid.org/0009-0007-1595-4332"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Arief A. Suriawinata","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064750288","display_name":"Stephanie C. Her","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephanie C. Her","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028989565","display_name":"Christopher Ian Amos","orcid":"https://orcid.org/0000-0002-8540-7023","observed_orcids":["https://orcid.org/0000-0002-8540-7023","https://orcid.org/0000-0002-9006-7203"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher I. Amos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5081988343","display_name":"Richard J. Barth","orcid":"https://orcid.org/0000-0002-5516-207X","observed_orcids":["https://orcid.org/0000-0002-5516-207X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard J. Barth","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.007899999618530273,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.8410000205039978},{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.8190000057220459},{"id":"https://openalex.org/keywords/adjuvant-immunotherapy","display_name":"adjuvant immunotherapy","score":0.9279999732971191},{"id":"https://openalex.org/keywords/vaccine-response-prediction","display_name":"vaccine response prediction","score":0.7409999966621399},{"id":"https://openalex.org/keywords/pi3k-akt-mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.9539999961853027},{"id":"https://openalex.org/keywords/plasma-membrane-proteins","display_name":"plasma membrane proteins","score":0.9769999980926514},{"id":"https://openalex.org/keywords/leave-one-out-cross-validation","display_name":"leave-one-out cross-validation","score":0.9200000166893005},{"id":"https://openalex.org/keywords/nk-cell-cytotoxicity","display_name":"NK cell cytotoxicity","score":0.7409999966621399},{"id":"https://openalex.org/keywords/caspase-pathway","display_name":"caspase pathway","score":0.7139999866485596},{"id":"https://openalex.org/keywords/pparalpha","display_name":"PPAR\u03b1","score":0.6990000009536743},{"id":"https://openalex.org/keywords/amino-acid-metabolism","display_name":"amino acid metabolism","score":0.7730000019073486},{"id":"https://openalex.org/keywords/extracellular-matrix-receptor-interaction","display_name":"extracellular matrix-receptor interaction","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6407269239425659},{"id":"https://openalex.org/C195687474","wikidata":"https://www.wikidata.org/wiki/Q409715","display_name":"Integrin","level":3,"score":0.589928150177002},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5194734930992126},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.5001819133758545},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4849681854248047},{"id":"https://openalex.org/C2777863537","wikidata":"https://www.wikidata.org/wiki/Q357896","display_name":"Adjuvant","level":2,"score":0.4480118751525879},{"id":"https://openalex.org/C2779251935","wikidata":"https://www.wikidata.org/wiki/Q5385089","display_name":"ErbB","level":3,"score":0.44092199206352234},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3693801760673523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35974210500717163},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.34359806776046753},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33960816264152527},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30952489376068115},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27449947595596313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21524405479431152},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.20959162712097168},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17264729738235474},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16563120484352112},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22467551.v1","doi":"https://doi.org/10.1158/1078-0432.22467551.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22467551.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22467551.v1","doi":"https://doi.org/10.1158/1078-0432.22467551.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22467551.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2479510994","https://openalex.org/W2485111356","https://openalex.org/W4361956489","https://openalex.org/W4361886415","https://openalex.org/W4361887084","https://openalex.org/W2102403364","https://openalex.org/W2793538407","https://openalex.org/W4403305822","https://openalex.org/W2153028146","https://openalex.org/W1877643258"],"abstract_inverted_index":{"Response":[0],"prediction":[1,74],"scores":[2,43],"for":[3],"22":[4],"rounds":[5],"of":[6,146],"leave-one-out":[7],"cross-validation":[8],"are":[9,30],"presented.":[10],"The":[11],"test":[12],"set":[13,26,40,66],"individual":[14],"in":[15,72,84],"each":[16],"round":[17],"is":[18],"denoted":[19,31],"by":[20,32],"a":[21],"black":[22],"asterisk,":[23],"while":[24],"training":[25,65],"responders":[27],"and":[28,35,142,149],"non-responders":[29],"blue":[33],"dots":[34],"red":[36],"dots,":[37],"respectively.":[38],"Test":[39],"individuals":[41,67],"with":[42,61],"above/below":[44],"the":[45,55,73,85,123],"dashed":[46],"line":[47],"were":[48],"predicted":[49],"to":[50,58,78],"be":[51,59],"vaccine":[52,62],"responders/non-responders.":[53],"Of":[54],"variants":[56],"found":[57],"associated":[60],"response":[63],"among":[64],"(P":[68],"<":[69],"0.005),":[70],"up-weighting":[71],"model":[75],"was":[76],"applied":[77],"those":[79],"within":[80],"genes":[81],"that":[82],"participate":[83],"following":[86],"pathways:":[87],"(A)":[88],"no":[89],"pathway,":[90,108,112,116,136,141],"(B)":[91],"KEGG:":[92,98],"Extracellular":[93],"matrix":[94],"receptor":[95],"interactions,":[96],"(C)":[97],"Natural":[99],"killer":[100],"cell":[101],"mediated":[102],"cytotoxicity,":[103],"(D)":[104],"PID:":[105,110,114,133,138],"\u03b1V\u03b23":[106],"integrin":[107,135],"(E)":[109],"Caspase":[111],"(F)":[113],"SHP2":[115],"(G)":[117],"REACTOME:":[118,127,144],"Cell":[119],"surface":[120],"interactions":[121],"at":[122],"vascular":[124],"wall,":[125],"(H)":[126],"PPAR\u03b1":[128],"activates":[129],"gene":[130],"expression,":[131],"(I)":[132],"\u03b1M\u03b22":[134],"(J)":[137],"Integrin":[139],"1":[140],"(K)":[143],"Metabolism":[145],"amino":[147],"acids":[148],"derivatives.":[150]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2023-04-05T00:00:00"}