{"id":"https://openalex.org/W4361928858","doi":"https://doi.org/10.1158/1078-0432.22466547","title":"SUPPLEMENTAL MATERIALS from Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody","display_name":"SUPPLEMENTAL MATERIALS from Results from an Integrated Safety Analysis of Urelumab, an Agonist Anti-CD137 Monoclonal Antibody","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361928858","doi":"https://doi.org/10.1158/1078-0432.22466547"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22466547","doi":"https://doi.org/10.1158/1078-0432.22466547","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22466547","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/SUPPLEMENTAL_MATERIALS_from_Results_from_an_Integrated_Safety_Analysis_of_Urelumab_an_Agonist_Anti-CD137_Monoclonal_Antibody/22466547/1/files/39917931.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/SUPPLEMENTAL_MATERIALS_from_Results_from_an_Integrated_Safety_Analysis_of_Urelumab_an_Agonist_Anti-CD137_Monoclonal_Antibody/22466547/1/files/39917931.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062202820","display_name":"Neil Howard Segal","orcid":"https://orcid.org/0000-0002-3047-2303","observed_orcids":["https://orcid.org/0000-0002-3047-2303"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil H. Segal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103165801","display_name":"Theodore F. Logan","orcid":"https://orcid.org/0000-0002-9245-0820","observed_orcids":["https://orcid.org/0000-0002-9245-0820"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Theodore F. Logan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084967339","display_name":"Frank Stephen Hodi","orcid":"https://orcid.org/0000-0001-6825-091X","observed_orcids":["https://orcid.org/0000-0001-6825-091X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Stephen Hodi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007052233","display_name":"David F. McDermott","orcid":"https://orcid.org/0000-0002-2675-5095","observed_orcids":["https://orcid.org/0000-0002-2675-5095","https://orcid.org/0000-0001-6978-0867"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David McDermott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029243551","display_name":"Ignacio Melero","orcid":"https://orcid.org/0000-0002-1360-348X","observed_orcids":["https://orcid.org/0000-0002-1360-348X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ignacio Melero","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028592995","display_name":"Omid Hamid","orcid":"https://orcid.org/0000-0002-8238-4655","observed_orcids":["https://orcid.org/0000-0002-8238-4655"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Omid Hamid","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Henrik Schmidt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Henrik Schmidt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100713900","display_name":"Caroline Robert","orcid":"https://orcid.org/0000-0002-9493-0238","observed_orcids":["https://orcid.org/0000-0002-9493-0238"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Caroline Robert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031591368","display_name":"Vanna Chiarion\u2010Sileni","orcid":"https://orcid.org/0000-0001-9191-9124","observed_orcids":["https://orcid.org/0000-0001-9191-9124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vanna Chiarion-Sileni","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029398339","display_name":"Paolo A. Ascierto","orcid":"https://orcid.org/0000-0002-8322-475X","observed_orcids":["https://orcid.org/0000-0002-8322-475X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paolo A. Ascierto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018536695","display_name":"Michele Maio","orcid":"https://orcid.org/0000-0002-0323-6321","observed_orcids":["https://orcid.org/0000-0002-0323-6321"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michele Maio","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025100380","display_name":"Walter John Urba","orcid":"https://orcid.org/0000-0001-8414-3348","observed_orcids":["https://orcid.org/0000-0001-8414-3348"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Walter J. Urba","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109331981","display_name":"Tara C. Gangadhar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tara C. Gangadhar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022616203","display_name":"Satyendra Suryawanshi","orcid":"https://orcid.org/0009-0002-8657-4760","observed_orcids":["https://orcid.org/0009-0002-8657-4760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satyendra Suryawanshi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031019650","display_name":"Jaclyn Neely","orcid":"https://orcid.org/0000-0001-7137-3953","observed_orcids":["https://orcid.org/0000-0001-7137-3953"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaclyn Neely","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019908292","display_name":"Maria Jure\u2010Kunkel","orcid":"https://orcid.org/0000-0002-3751-1934","observed_orcids":["https://orcid.org/0000-0002-3751-1934"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Jure-Kunkel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109348433","display_name":"Suba Krishnan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suba Krishnan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108298451","display_name":"Holbrook E K Kohrt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Holbrook Kohrt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007198397","display_name":"Mario Sznol","orcid":"https://orcid.org/0000-0003-4137-9662","observed_orcids":["https://orcid.org/0000-0003-4137-9662"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mario Sznol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5083342021","display_name":"Ronald Levy","orcid":"https://orcid.org/0000-0003-2061-0650","observed_orcids":["https://orcid.org/0000-0003-2061-0650"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald Levy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.7764000296592712,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.08060000091791153,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urelumab","display_name":"urelumab","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-cd137-monoclonal-antibody","display_name":"anti-CD137 monoclonal antibody","score":0.9350000023841858},{"id":"https://openalex.org/keywords/integrated-safety-analysis","display_name":"integrated safety analysis","score":0.8539999723434448},{"id":"https://openalex.org/keywords/exposure-response-analysis","display_name":"exposure-response analysis","score":0.5460000038146973},{"id":"https://openalex.org/keywords/dose-proportionality","display_name":"dose proportionality","score":0.7009999752044678},{"id":"https://openalex.org/keywords/interferon-response-genes","display_name":"interferon response genes","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.5189732909202576},{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.5066007375717163},{"id":"https://openalex.org/C2780249625","wikidata":"https://www.wikidata.org/wiki/Q14913226","display_name":"CD137","level":4,"score":0.4763334393501282},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46562808752059937},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.4583953619003296},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4379939138889313},{"id":"https://openalex.org/C204323151","wikidata":"https://www.wikidata.org/wiki/Q905424","display_name":"Range (aeronautics)","level":2,"score":0.4101094603538513},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34177064895629883},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.24203485250473022},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22569897770881653},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.18344628810882568},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.14367860555648804},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.13844463229179382},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1138375997543335},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22466547","doi":"https://doi.org/10.1158/1078-0432.22466547","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22466547","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/SUPPLEMENTAL_MATERIALS_from_Results_from_an_Integrated_Safety_Analysis_of_Urelumab_an_Agonist_Anti-CD137_Monoclonal_Antibody/22466547/1/files/39917931.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22466547.v1","doi":"https://doi.org/10.1158/1078-0432.22466547.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22466547.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22466547","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/SUPPLEMENTAL_MATERIALS_from_Results_from_an_Integrated_Safety_Analysis_of_Urelumab_an_Agonist_Anti-CD137_Monoclonal_Antibody/22466547","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22466547","doi":"https://doi.org/10.1158/1078-0432.22466547","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22466547","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/SUPPLEMENTAL_MATERIALS_from_Results_from_an_Integrated_Safety_Analysis_of_Urelumab_an_Agonist_Anti-CD137_Monoclonal_Antibody/22466547/1/files/39917931.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361928858.pdf","grobid_xml":"https://content.openalex.org/works/W4361928858.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2537734913","https://openalex.org/W4361959481","https://openalex.org/W7136752188","https://openalex.org/W7136250254","https://openalex.org/W7136339558","https://openalex.org/W7136291802","https://openalex.org/W7136487714","https://openalex.org/W7136179306","https://openalex.org/W7137260550","https://openalex.org/W7136307726"],"abstract_inverted_index":{"Methods":[0],"Supplement":[1],"Supplementary":[2,10,24,41],"Table":[3,11],"1.":[4,26],"Patients":[5,13],"Included":[6,20],"in":[7,21],"E-R":[8],"Analysis":[9,23],"2.":[12,43],"From":[14],"Studies":[15],"-006":[16],"and":[17],"-011":[18],"Not":[19],"ER":[22],"Fig":[25,42],"Serum":[27],"concentration:time":[28],"profile":[29],"of":[30,45,48],"urelumab":[31,52],"across":[32],"the":[33],"dose":[34],"range":[35,47],"evaluated":[36],"(0.1":[37],"to":[38],"15":[39],"mg/kg)":[40],"Induction":[44],"a":[46],"IFN-response":[49],"genes":[50],"by":[51],"0.1":[53],"mg/kg":[54]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}