{"id":"https://openalex.org/W4361925248","doi":"https://doi.org/10.1158/1078-0432.22464647.v1","title":"Supplementary Figures from Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors","display_name":"Supplementary Figures from Overcoming Resistance to DNA-Targeted Agents by Epigenetic Activation of Schlafen 11 (SLFN11) Expression with Class I Histone Deacetylase Inhibitors","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361925248","doi":"https://doi.org/10.1158/1078-0432.22464647.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22464647.v1","doi":"https://doi.org/10.1158/1078-0432.22464647.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22464647.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22464647.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024478289","display_name":"Sai-Wen Tang","orcid":"https://orcid.org/0000-0001-8577-2461","observed_orcids":["https://orcid.org/0000-0001-8577-2461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sai-Wen Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074644543","display_name":"Anish Thomas","orcid":"https://orcid.org/0000-0003-3293-3115","observed_orcids":["https://orcid.org/0000-0003-3293-3115"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anish Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074228660","display_name":"Junko Murai","orcid":"https://orcid.org/0000-0003-2023-6160","observed_orcids":["https://orcid.org/0000-0003-2023-6160"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junko Murai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040289016","display_name":"Jane B. Trepel","orcid":"https://orcid.org/0000-0002-7681-6554","observed_orcids":["https://orcid.org/0000-0002-7681-6554"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jane B. Trepel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013592290","display_name":"Susan Elaine Bates","orcid":"https://orcid.org/0000-0001-6708-0330","observed_orcids":["https://orcid.org/0000-0001-6708-0330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan E. Bates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009108088","display_name":"Vinodh N. Rajapakse","orcid":"https://orcid.org/0000-0002-5214-1089","observed_orcids":["https://orcid.org/0000-0002-5214-1089"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vinodh N. Rajapakse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042114293","display_name":"Yves G. Pommier","orcid":"https://orcid.org/0000-0002-3108-0758","observed_orcids":["https://orcid.org/0000-0002-3108-0758"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yves Pommier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.7455999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.2287999987602234,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12820","display_name":"Chromatin Remodeling and Cancer","score":0.006099999882280827,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/slfn11","display_name":"SLFN11","score":0.9879999756813049},{"id":"https://openalex.org/keywords/schlafen-11","display_name":"Schlafen 11","score":0.8169999718666077},{"id":"https://openalex.org/keywords/histone-deacetylase-inhibitors","display_name":"histone deacetylase inhibitors","score":0.8679999709129333},{"id":"https://openalex.org/keywords/romidepsin","display_name":"romidepsin","score":0.9929999709129333},{"id":"https://openalex.org/keywords/entinostat","display_name":"entinostat","score":0.9900000095367432},{"id":"https://openalex.org/keywords/camptothecin","display_name":"camptothecin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7149999737739563},{"id":"https://openalex.org/keywords/epigenetic-activation","display_name":"epigenetic activation","score":0.7450000047683716},{"id":"https://openalex.org/keywords/fli1","display_name":"FLI1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/colon-cancer","display_name":"colon cancer","score":0.640999972820282},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.7300000190734863},{"id":"https://openalex.org/keywords/nci-60-cell-lines","display_name":"NCI-60 cell lines","score":0.75},{"id":"https://openalex.org/keywords/transcriptional-derepression","display_name":"transcriptional derepression","score":0.6389999985694885}],"concepts":[{"id":"https://openalex.org/C2781462825","wikidata":"https://www.wikidata.org/wiki/Q7363205","display_name":"Romidepsin","level":5,"score":0.9386906027793884},{"id":"https://openalex.org/C2779682216","wikidata":"https://www.wikidata.org/wiki/Q419964","display_name":"Camptothecin","level":2,"score":0.5926700234413147},{"id":"https://openalex.org/C2778305200","wikidata":"https://www.wikidata.org/wiki/Q174378","display_name":"Histone deacetylase","level":4,"score":0.559746503829956},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5250080823898315},{"id":"https://openalex.org/C2779085176","wikidata":"https://www.wikidata.org/wiki/Q24721644","display_name":"Histone H4","level":4,"score":0.4780628979206085},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.4716467261314392},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3784070611000061},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3632762134075165},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36129987239837646},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.2974763512611389},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2898072600364685},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13076573610305786},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.10450229048728943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08609947562217712}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22464647.v1","doi":"https://doi.org/10.1158/1078-0432.22464647.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22464647.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22464647","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_from_Overcoming_Resistance_to_DNA-Targeted_Agents_by_Epigenetic_Activation_of_Schlafen_11_i_SLFN11_i_Expression_with_Class_I_Histone_Deacetylase_Inhibitors/22464647","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22464647.v1","doi":"https://doi.org/10.1158/1078-0432.22464647.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22464647.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2144993884","https://openalex.org/W1513102126","https://openalex.org/W2038477243","https://openalex.org/W2075351620","https://openalex.org/W1483077634","https://openalex.org/W2083124842","https://openalex.org/W178791954","https://openalex.org/W2015645056","https://openalex.org/W317378354","https://openalex.org/W2302499530"],"abstract_inverted_index":{"Supplementary":[0,14,28,49],"Fig.":[1,15,29,50],"S1.":[2],"Romidepsin":[3],"derepresses":[4],"SLFN11":[5,18,33,54],"expression":[6,19],"in":[7,68],"cancer":[8,23],"cell":[9],"lines":[10],"from":[11],"the":[12,40],"NCI-60.":[13],"S2.":[16],"Forcing":[17],"sensitizes":[20,57],"human":[21],"colon":[22],"HCT116":[24],"cells":[25,61],"to":[26,62],"camptothecin.":[27],"S3.":[30],"Induction":[31],"of":[32,35,39,46,53],"independently":[34],"FLI1,":[36],"rapid":[37],"reversal":[38],"romidepsin":[41],"effect":[42,67],"and":[43,59,64],"short":[44],"half-life":[45],"SLN11":[47],"transcripts.":[48],"4.":[51],"Derepression":[52],"by":[55],"entinostat":[56],"H82":[58],"HH":[60],"camptothecin":[63],"exhibit":[65],"additive":[66],"H446":[69],"cells.":[70]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}