{"id":"https://openalex.org/W4361921980","doi":"https://doi.org/10.1158/1078-0432.22462746.v1","title":"Online Supplementary Tables from Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma","display_name":"Online Supplementary Tables from Preclinical Therapeutic Synergy of MEK1/2 and CDK4/6 Inhibition in Neuroblastoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361921980","doi":"https://doi.org/10.1158/1078-0432.22462746.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22462746.v1","doi":"https://doi.org/10.1158/1078-0432.22462746.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22462746.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22462746.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008979088","display_name":"Lori S. Hart","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lori S. Hart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034411606","display_name":"JulieAnn Rader","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JulieAnn Rader","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068529122","display_name":"Pichai Raman","orcid":"https://orcid.org/0000-0001-6948-2157","observed_orcids":["https://orcid.org/0000-0001-6948-2157"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pichai Raman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031062394","display_name":"Vandana Batra","orcid":"https://orcid.org/0000-0003-2963-4835","observed_orcids":["https://orcid.org/0000-0003-2963-4835"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vandana Batra","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041038775","display_name":"Mike R. Russell","orcid":"https://orcid.org/0009-0009-5898-2020","observed_orcids":["https://orcid.org/0009-0009-5898-2020"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike R. Russell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048910641","display_name":"Matthew Tsang","orcid":"https://orcid.org/0000-0002-2983-2914","observed_orcids":["https://orcid.org/0000-0002-2983-2914"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew Tsang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Maria Gagliardi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Gagliardi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037219238","display_name":"Lucy L Chen","orcid":"https://orcid.org/0000-0002-9956-8194","observed_orcids":["https://orcid.org/0000-0002-9956-8194"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lucy Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100690100","display_name":"Daniel Mart\u0131\u0301nez","orcid":"https://orcid.org/0000-0001-7492-5311","observed_orcids":["https://orcid.org/0000-0001-7492-5311"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Martinez","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017202683","display_name":"Yimei Li","orcid":"https://orcid.org/0000-0001-9067-6992","observed_orcids":["https://orcid.org/0000-0001-9067-6992","https://orcid.org/0000-0002-7046-4316"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yimei Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101465178","display_name":"Andrew M. Wood","orcid":"https://orcid.org/0000-0001-6863-0824","observed_orcids":["https://orcid.org/0000-0001-6863-0824"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew Wood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000850685","display_name":"Sunkyu Kim","orcid":"https://orcid.org/0000-0002-0240-6210","observed_orcids":["https://orcid.org/0000-0002-0240-6210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sunkyu Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110082","display_name":"Sudha Parasuraman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sudha Parasuraman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016326595","display_name":"Scott M. Delach","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Delach","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005796905","display_name":"Kristina Ann Cole","orcid":"https://orcid.org/0000-0003-0064-2882","observed_orcids":["https://orcid.org/0000-0003-0064-2882"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kristina A. Cole","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061418960","display_name":"Shiva Krupa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiva Krupa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065761868","display_name":"Markus Boehm","orcid":"https://orcid.org/0000-0002-7025-3287","observed_orcids":["https://orcid.org/0000-0002-7025-3287"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Markus Boehm","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Malte Peters","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Malte Peters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025118565","display_name":"Giordano Caponigro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giordano Caponigro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005797590","display_name":"John M. Maris","orcid":"https://orcid.org/0000-0002-8088-7929","observed_orcids":["https://orcid.org/0000-0002-8088-7929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John M. Maris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11173","display_name":"Neurofibromatosis and Schwannoma Cases","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mek1-2-inhibition","display_name":"MEK1/2 inhibition","score":0.9900000095367432},{"id":"https://openalex.org/keywords/cdk4-6-inhibition","display_name":"CDK4/6 inhibition","score":0.9990000128746033},{"id":"https://openalex.org/keywords/binimetinib","display_name":"binimetinib","score":0.9129999876022339},{"id":"https://openalex.org/keywords/ribociclib","display_name":"ribociclib","score":1.0},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.8840000033378601},{"id":"https://openalex.org/keywords/therapeutic-synergy","display_name":"therapeutic synergy","score":0.8009999990463257},{"id":"https://openalex.org/keywords/mutation","display_name":"genetic mutations","score":0.6650000214576721},{"id":"https://openalex.org/keywords/microarray-gene-expression","display_name":"microarray gene expression","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C45235069","wikidata":"https://www.wikidata.org/wiki/Q278425","display_name":"Table (database)","level":2,"score":0.6158100962638855},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5684911608695984},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.4474751651287079},{"id":"https://openalex.org/C2776291640","wikidata":"https://www.wikidata.org/wiki/Q2912517","display_name":"Value (mathematics)","level":2,"score":0.44461965560913086},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.42934292554855347},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.42291563749313354},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41807034611701965},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38778361678123474},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37950843572616577},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3741776943206787},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36222201585769653},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3520697355270386},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32706373929977417},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.20651906728744507},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.1900271475315094},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.1722411811351776},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.17154952883720398},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.1518493890762329},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0858561098575592}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22462746.v1","doi":"https://doi.org/10.1158/1078-0432.22462746.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22462746.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22462746","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Online_Supplementary_Tables_from_Preclinical_Therapeutic_Synergy_of_MEK1_2_and_CDK4_6_Inhibition_in_Neuroblastoma/22462746","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22462746.v1","doi":"https://doi.org/10.1158/1078-0432.22462746.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22462746.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361945277","https://openalex.org/W2530482928","https://openalex.org/W6977573676","https://openalex.org/W2289394228","https://openalex.org/W2566666946","https://openalex.org/W6902322847","https://openalex.org/W4282960716","https://openalex.org/W3135344087","https://openalex.org/W3047160360","https://openalex.org/W4285594123"],"abstract_inverted_index":{"Table":[0,8,10,20],"S1.":[1],"Specific":[2],"mutations":[3],"of":[4,16,51],"genes":[5,40],"listed":[6],"in":[7,29],"1.":[9],"S2.":[11],"Foundation":[12],"Medicine":[13],"sequencing":[14],"calls":[15],"cancer-specific":[17],"gene":[18],"panel.":[19],"S3.":[21],"Gene":[22],"lists":[23],"corresponding":[24],"to":[25],"microarray":[26],"analysis":[27],"described":[28],"Figures":[30],"1A":[31],"and":[32,36],"1B:":[33],"(A)":[34],"binimetinib":[35],"(B)":[37],"ribociclib.":[38],"Significant":[39],"(in":[41],"bold":[42],"type)":[43],"are":[44],"defined":[45],"as":[46],"having":[47],"an":[48],"adjusted":[49],"p-value":[50],"0.25":[52],"or":[53],"less.":[54]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2023-04-05T00:00:00"}
