{"id":"https://openalex.org/W4361920299","doi":"https://doi.org/10.1158/1078-0432.22461450.v1","title":"Supplemental Figure S3 from Chemotherapy Resistance in Diffuse-Type Gastric Adenocarcinoma Is Mediated by RhoA Activation in Cancer Stem-Like Cells","display_name":"Supplemental Figure S3 from Chemotherapy Resistance in Diffuse-Type Gastric Adenocarcinoma Is Mediated by RhoA Activation in Cancer Stem-Like Cells","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361920299","doi":"https://doi.org/10.1158/1078-0432.22461450.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22461450.v1","doi":"https://doi.org/10.1158/1078-0432.22461450.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22461450.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22461450.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087665828","display_name":"Changhwan Yoon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Changhwan Yoon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061084622","display_name":"Soo\u2010Jeong Cho","orcid":"https://orcid.org/0000-0001-7144-0589","observed_orcids":["https://orcid.org/0000-0001-7144-0589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Soo-Jeong Cho","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020220136","display_name":"B\u00fclent Arman Aksoy","orcid":"https://orcid.org/0000-0002-0135-2505","observed_orcids":["https://orcid.org/0000-0002-0135-2505"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B\u00fclent Arman Aksoy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011107729","display_name":"Do Joong Park","orcid":"https://orcid.org/0000-0001-9644-6127","observed_orcids":["https://orcid.org/0000-0001-9644-6127"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Do Joong Park","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033125884","display_name":"Nikolaus D. Schultz","orcid":"https://orcid.org/0000-0002-0131-4904","observed_orcids":["https://orcid.org/0000-0002-0131-4904"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikolaus Schultz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045541621","display_name":"Sandra W. Ryeom","orcid":"https://orcid.org/0000-0002-9869-4455","observed_orcids":["https://orcid.org/0000-0002-9869-4455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandra W. Ryeom","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008016189","display_name":"Sam Sukgoo Yoon","orcid":"https://orcid.org/0000-0002-9031-4198","observed_orcids":["https://orcid.org/0000-0002-9031-4198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sam S. Yoon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.6934000253677368,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.2957000136375427,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8149999976158142},{"id":"https://openalex.org/keywords/diffuse-type-gastric-adenocarcinoma","display_name":"diffuse-type gastric adenocarcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rhoa-activation","display_name":"RhoA activation","score":0.968999981880188},{"id":"https://openalex.org/keywords/cancer-stem-like-cells","display_name":"cancer stem-like cells","score":0.9990000128746033},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.8759999871253967},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.8479999899864197},{"id":"https://openalex.org/keywords/jnk","display_name":"JNK","score":0.9980000257492065},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.8489999771118164},{"id":"https://openalex.org/keywords/akt-inhibition","display_name":"AKT inhibition","score":0.7870000004768372},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.9539999961853027},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.8899999856948853}],"concepts":[{"id":"https://openalex.org/C2777093181","wikidata":"https://www.wikidata.org/wiki/Q15331450","display_name":"RHOA","level":3,"score":0.7903404235839844},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7483898401260376},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.6106545925140381},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5269323587417603},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4565931558609009},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.4405360221862793},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33434784412384033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3116301894187927},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3049946129322052},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30024200677871704},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2704256772994995},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.20710071921348572},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.15877795219421387}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1078-0432.22461450.v1","doi":"https://doi.org/10.1158/1078-0432.22461450.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22461450.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22461450.v1","doi":"https://doi.org/10.1158/1078-0432.22461450.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22461450.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2563950223","https://openalex.org/W4361953842","https://openalex.org/W2741689714","https://openalex.org/W4392700316","https://openalex.org/W2287840312","https://openalex.org/W1987716497","https://openalex.org/W2334557894","https://openalex.org/W2170278621","https://openalex.org/W2507247158","https://openalex.org/W3032504330"],"abstract_inverted_index":{"Expression":[0],"of":[1,8],"Akt,":[2],"ERK,":[3],"JNK,":[4],"p38,":[5],"and":[6,13],"effects":[7],"Akt":[9],"inhibition":[10],"on":[11],"migration":[12],"invasion.":[14]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2023-04-05T00:00:00"}