{"id":"https://openalex.org/W4361919299","doi":"https://doi.org/10.1158/1078-0432.22459887","title":"Supplementary Fig. 5 from Pancreatic Cancer\u2013Derived Exosomes Cause Paraneoplastic \u03b2-cell Dysfunction","display_name":"Supplementary Fig. 5 from Pancreatic Cancer\u2013Derived Exosomes Cause Paraneoplastic \u03b2-cell Dysfunction","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361919299","doi":"https://doi.org/10.1158/1078-0432.22459887"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22459887","doi":"https://doi.org/10.1158/1078-0432.22459887","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22459887","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22459887","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070228740","display_name":"Naureen Javeed","orcid":"https://orcid.org/0000-0003-0833-9239","observed_orcids":["https://orcid.org/0000-0003-0833-9239"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naureen Javeed","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003281763","display_name":"Gunisha Sagar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gunisha Sagar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074232729","display_name":"Shamit Kumar Dutta","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shamit K. Dutta","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049580044","display_name":"Thomas C. Smyrk","orcid":"https://orcid.org/0000-0001-6194-7853","observed_orcids":["https://orcid.org/0000-0001-6194-7853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas C. Smyrk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110668228","display_name":"Julie S. Lau","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie S. Lau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090701117","display_name":"Santanu Bhattacharya","orcid":"https://orcid.org/0000-0001-9040-8971","observed_orcids":["https://orcid.org/0000-0001-9040-8971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Santanu Bhattacharya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029404091","display_name":"Mark Joseph Truty","orcid":"https://orcid.org/0000-0003-3776-527X","observed_orcids":["https://orcid.org/0000-0003-3776-527X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Truty","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048782070","display_name":"Gloria M. Petersen","orcid":"https://orcid.org/0000-0003-3424-7039","observed_orcids":["https://orcid.org/0000-0003-3424-7039"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gloria M. Petersen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015378855","display_name":"Randal J. Kaufman","orcid":"https://orcid.org/0000-0003-4277-316X","observed_orcids":["https://orcid.org/0000-0003-4277-316X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Randal J. Kaufman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048460582","display_name":"Suresh T. Chari","orcid":"https://orcid.org/0000-0002-3924-0971","observed_orcids":["https://orcid.org/0000-0002-3924-0971"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Suresh T. Chari","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5042923310","display_name":"Debabrata Mukhopadhyay","orcid":"https://orcid.org/0000-0002-3159-8928","observed_orcids":["https://orcid.org/0000-0002-3159-8928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Debabrata Mukhopadhyay","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.5946999788284302,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.3637999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.005499999970197678,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adrenomedullin","display_name":"adrenomedullin","score":0.9200000166893005},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.5379999876022339},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.9150000214576721},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9100000262260437},{"id":"https://openalex.org/keywords/superoxide-radicals","display_name":"superoxide","score":0.777999997138977},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.9940000176429749},{"id":"https://openalex.org/keywords/ins-1-cells","display_name":"INS-1 cells","score":0.9340000152587891},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.9050735235214233},{"id":"https://openalex.org/C2777152744","wikidata":"https://www.wikidata.org/wiki/Q366935","display_name":"Adrenomedullin","level":3,"score":0.8207030892372131},{"id":"https://openalex.org/C2779525624","wikidata":"https://www.wikidata.org/wiki/Q225595","display_name":"Reactive nitrogen species","level":3,"score":0.7069273591041565},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5879082083702087},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.49415042996406555},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4011227488517761},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26113420724868774},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20923733711242676},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.08485937118530273},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22459887","doi":"https://doi.org/10.1158/1078-0432.22459887","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22459887","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22459887.v1","doi":"https://doi.org/10.1158/1078-0432.22459887.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22459887.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22459887","doi":"https://doi.org/10.1158/1078-0432.22459887","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22459887","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1933651537","https://openalex.org/W2126355299","https://openalex.org/W2478687866","https://openalex.org/W2124413979","https://openalex.org/W1967604577","https://openalex.org/W7058315215","https://openalex.org/W2027808216","https://openalex.org/W2093761649","https://openalex.org/W6942340041","https://openalex.org/W2009080781"],"abstract_inverted_index":{"Supplementary":[0],"Fig.":[1],"5.":[2],"Adrenomedullin":[3],"increases":[4],"reactive":[5,44],"oxygen":[6,45],"species":[7,11],"production.":[8,73],"Reactive":[9],"oxygen/nitrogen":[10],"(ROS/RNS)":[12],"were":[13,50,63],"detected":[14],"in":[15],"INS-1":[16],"cells":[17,49,62],"pre-treated":[18],"with":[19,52,65],"either":[20],"1":[21],"or":[22],"20":[23],"pM":[24],"adrenomedullin":[25],"for":[26],"24":[27],"hours.":[28],"The":[29],"orange":[30],"filter":[31,41],"detects":[32,42],"superoxide":[33],"and":[34,59],"nitric":[35],"oxide":[36],"generation,":[37],"while":[38],"the":[39],"green":[40],"all":[43],"species.":[46],"Positive":[47],"control":[48,61],"treated":[51,64],"Pyocyanin":[53],"(Pyo)":[54],"to":[55,70],"induce":[56],"ROS":[57,72],"production":[58],"negative":[60],"Pyo":[66],"+":[67],"N-acetyl-L-cysteine":[68],"(NAC)":[69],"inhibit":[71],"Scale":[74],"bar":[75],"represents":[76],"10":[77],"\u00b5m.":[78]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}