{"id":"https://openalex.org/W4361913239","doi":"https://doi.org/10.1158/1078-0432.22457165","title":"Supplementary Tables from Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients","display_name":"Supplementary Tables from Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361913239","doi":"https://doi.org/10.1158/1078-0432.22457165"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22457165","doi":"https://doi.org/10.1158/1078-0432.22457165","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22457165","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22457165","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104109941","display_name":"Andrew P. Garner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew P. Garner","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047497236","display_name":"Joseph M. Gozgit","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph M. Gozgit","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101834684","display_name":"Rana Anjum","orcid":"https://orcid.org/0000-0002-5354-1797","observed_orcids":["https://orcid.org/0000-0002-5354-1797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rana Anjum","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085282433","display_name":"Sadanand Vodala","orcid":"https://orcid.org/0000-0002-4913-5999","observed_orcids":["https://orcid.org/0000-0002-4913-5999"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sadanand Vodala","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062019987","display_name":"Alexa Betzig Schrock","orcid":"https://orcid.org/0000-0003-0106-9096","observed_orcids":["https://orcid.org/0000-0003-0106-9096"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexa Schrock","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Tianjun Zhou","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tianjun Zhou","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054426858","display_name":"C\u00e9sar Serrano","orcid":"https://orcid.org/0000-0003-1416-8739","observed_orcids":["https://orcid.org/0000-0003-1416-8739"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cesar Serrano","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084829609","display_name":"Grant Eilers","orcid":"https://orcid.org/0000-0001-9191-5932","observed_orcids":["https://orcid.org/0000-0001-9191-5932"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Grant Eilers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049104586","display_name":"Meijun J. Zhu","orcid":"https://orcid.org/0000-0001-8027-1780","observed_orcids":["https://orcid.org/0000-0001-8027-1780"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meijun Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080989229","display_name":"Julia Ketzer","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julia Ketzer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030692726","display_name":"Scott Wardwell","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scott Wardwell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083951706","display_name":"Yaoyu Ning","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yaoyu Ning","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108833518","display_name":"Youngchul Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youngchul Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060078114","display_name":"Anna Kohlmann","orcid":"https://orcid.org/0000-0003-1303-654X","observed_orcids":["https://orcid.org/0000-0003-1303-654X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Kohlmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103088480","display_name":"Frank Wang","orcid":"https://orcid.org/0000-0002-1048-4462","observed_orcids":["https://orcid.org/0000-0002-1048-4462"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Frank Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109928146","display_name":"Tim Clackson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tim Clackson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091057405","display_name":"Michael Charles Heinrich","orcid":"https://orcid.org/0000-0003-3790-0478","observed_orcids":["https://orcid.org/0000-0003-3790-0478"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael C. Heinrich","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040359760","display_name":"Jonathan Alfred Fletcher","orcid":"https://orcid.org/0000-0002-5109-2588","observed_orcids":["https://orcid.org/0000-0002-5109-2588"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan A. Fletcher","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031540987","display_name":"Sebastian Bauer","orcid":"https://orcid.org/0000-0001-5949-8120","observed_orcids":["https://orcid.org/0000-0001-5949-8120"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sebastian Bauer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5084036570","display_name":"Victor M. Rivera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Victor M. Rivera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11485","display_name":"Gastrointestinal Tumor Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ponatinib","display_name":"ponatinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/kit","display_name":"KIT","score":0.7549999952316284},{"id":"https://openalex.org/keywords/gastrointestinal-stromal-tumor","display_name":"gastrointestinal stromal tumor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.925000011920929},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.546999990940094},{"id":"https://openalex.org/keywords/ba-f3-cells","display_name":"Ba/F3 cells","score":0.8450000286102295},{"id":"https://openalex.org/keywords/kit-mutations","display_name":"KIT mutations","score":0.7020000219345093},{"id":"https://openalex.org/keywords/cell-viability","display_name":"cell viability","score":0.6759999990463257},{"id":"https://openalex.org/keywords/in-vivo-tumor-growth","display_name":"in vivo tumor growth","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.9001363515853882},{"id":"https://openalex.org/C2780381907","wikidata":"https://www.wikidata.org/wiki/Q198728","display_name":"Ponatinib","level":5,"score":0.7418018579483032},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.6550787687301636},{"id":"https://openalex.org/C2777752497","wikidata":"https://www.wikidata.org/wiki/Q286779","display_name":"IC50","level":3,"score":0.5396947264671326},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5168914794921875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4881466329097748},{"id":"https://openalex.org/C2777007597","wikidata":"https://www.wikidata.org/wiki/Q16869243","display_name":"Stromal tumor","level":3,"score":0.4554649293422699},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.4243807792663574},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4140823185443878},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.4103754758834839},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3763083815574646},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.35498011112213135},{"id":"https://openalex.org/C2777413986","wikidata":"https://www.wikidata.org/wiki/Q412327","display_name":"Nilotinib","level":4,"score":0.342867374420166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29581284523010254},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25728240609169006},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06924045085906982},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.06408146023750305},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/1078-0432.22457165","doi":"https://doi.org/10.1158/1078-0432.22457165","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22457165","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/1078-0432.22457165.v1","doi":"https://doi.org/10.1158/1078-0432.22457165.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22457165.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22457165","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Tables_from_Ponatinib_Inhibits_Polyclonal_Drug-Resistant_KIT_Oncoproteins_and_Shows_Therapeutic_Potential_in_Heavily_Pretreated_Gastrointestinal_Stromal_Tumor_GIST_Patients/22457165","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22457165","doi":"https://doi.org/10.1158/1078-0432.22457165","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22457165","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361944958","https://openalex.org/W2109791697","https://openalex.org/W2612255169","https://openalex.org/W2323173556","https://openalex.org/W6955070727","https://openalex.org/W2059939877","https://openalex.org/W4414709634","https://openalex.org/W2278555352","https://openalex.org/W4412720622","https://openalex.org/W1845065486"],"abstract_inverted_index":{"Supplementary":[0],"Tables.":[1],"Table":[2,16,28,39],"S1.":[3],"In":[4,46],"Vitro":[5],"Kinase":[6],"IC50":[7,32],"Values":[8,34],"(nM)":[9],"for":[10],"Native":[11],"and":[12],"Mutant":[13],"Recombinant":[14],"KIT.":[15],"S2.":[17],"Summary":[18,30,41],"of":[19,31,42],"Ba/F3":[20,36,45],"KIT":[21,37,43],"Cell":[22],"Lines":[23],"Generated":[24],"in":[25,35],"this":[26],"Study.":[27],"S3.":[29],"Viability":[33],"Cells.":[38],"S4.":[40],"Driven":[44],"Vivo":[47],"Studies.":[48]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}
