{"id":"https://openalex.org/W4361908950","doi":"https://doi.org/10.1158/1078-0432.22451252.v1","title":"Supplementary Figure 1 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-\u03baB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells","display_name":"Supplementary Figure 1 from The Nedd8-Activating Enzyme Inhibitor MLN4924 Thwarts Microenvironment-Driven NF-\u03baB Activation and Induces Apoptosis in Chronic Lymphocytic Leukemia B Cells","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361908950","doi":"https://doi.org/10.1158/1078-0432.22451252.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22451252.v1","doi":"https://doi.org/10.1158/1078-0432.22451252.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451252.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_The_Nedd8-Activating_Enzyme_Inhibitor_MLN4924_Thwarts_Microenvironment-Driven_NF-_B_Activation_and_Induces_Apoptosis_in_Chronic_Lymphocytic_Leukemia_B_Cells/22451252/1/files/39902336.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_The_Nedd8-Activating_Enzyme_Inhibitor_MLN4924_Thwarts_Microenvironment-Driven_NF-_B_Activation_and_Induces_Apoptosis_in_Chronic_Lymphocytic_Leukemia_B_Cells/22451252/1/files/39902336.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065986445","display_name":"J. Claire Godbersen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. Claire Godbersen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064497631","display_name":"Leigh Ann Humphries","orcid":"https://orcid.org/0009-0007-4486-9903","observed_orcids":["https://orcid.org/0009-0007-4486-9903"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Leigh Ann Humphries","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103039650","display_name":"Olga V. Danilova","orcid":"https://orcid.org/0000-0001-9557-9032","observed_orcids":["https://orcid.org/0000-0001-9557-9032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga V. Danilova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052944129","display_name":"Peter E. Kebbekus","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter E. Kebbekus","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016570475","display_name":"Jennifer R. Brown","orcid":"https://orcid.org/0000-0003-2040-4961","observed_orcids":["https://orcid.org/0000-0003-2040-4961"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jennifer R. Brown","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016470161","display_name":"Alan R. Eastman","orcid":"https://orcid.org/0000-0002-8044-3092","observed_orcids":["https://orcid.org/0000-0002-8044-3092"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Eastman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5067633124","display_name":"Alexey Valeryevich Danilov","orcid":"https://orcid.org/0000-0003-4461-0970","observed_orcids":["https://orcid.org/0000-0003-4461-0970"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexey V. Danilov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mln4924","display_name":"MLN4924","score":0.9980000257492065},{"id":"https://openalex.org/keywords/nedd8-activating-enzyme-inhibitor","display_name":"NEDD8-activating enzyme inhibitor","score":0.9150000214576721},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"chronic lymphocytic leukemia","score":0.9940000176429749},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.6679999828338623},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.949999988079071},{"id":"https://openalex.org/keywords/nf-kappab-activation","display_name":"NF-\u03baB activation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9190000295639038},{"id":"https://openalex.org/keywords/ighv-mutation","display_name":"IGHV mutation","score":0.7630000114440918},{"id":"https://openalex.org/keywords/17p-deletion","display_name":"17p deletion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/cytogenetics","display_name":"cytogenetics","score":0.7699999809265137}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7881600856781006},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.7537696361541748},{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.6660707592964172},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.552832305431366},{"id":"https://openalex.org/C39347974","wikidata":"https://www.wikidata.org/wiki/Q21135811","display_name":"CD40","level":4,"score":0.5336201190948486},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.5261425971984863},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5158754587173462},{"id":"https://openalex.org/C81089528","wikidata":"https://www.wikidata.org/wiki/Q5134986","display_name":"clone (Java method)","level":3,"score":0.5084366202354431},{"id":"https://openalex.org/C2777609679","wikidata":"https://www.wikidata.org/wiki/Q5971015","display_name":"IGHV@","level":4,"score":0.5056838989257812},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.50128173828125},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.49555909633636475},{"id":"https://openalex.org/C138626823","wikidata":"https://www.wikidata.org/wiki/Q916504","display_name":"Chromosomal translocation","level":3,"score":0.4380415976047516},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.3157532811164856},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20335456728935242},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.20019477605819702},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13560333847999573},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.1221015453338623},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10349059104919434},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07908353209495544},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.06976640224456787}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22451252.v1","doi":"https://doi.org/10.1158/1078-0432.22451252.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451252.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_The_Nedd8-Activating_Enzyme_Inhibitor_MLN4924_Thwarts_Microenvironment-Driven_NF-_B_Activation_and_Induces_Apoptosis_in_Chronic_Lymphocytic_Leukemia_B_Cells/22451252/1/files/39902336.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22451252","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_The_Nedd8-Activating_Enzyme_Inhibitor_MLN4924_Thwarts_Microenvironment-Driven_NF-_B_Activation_and_Induces_Apoptosis_in_Chronic_Lymphocytic_Leukemia_B_Cells/22451252","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22451252.v1","doi":"https://doi.org/10.1158/1078-0432.22451252.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451252.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_The_Nedd8-Activating_Enzyme_Inhibitor_MLN4924_Thwarts_Microenvironment-Driven_NF-_B_Activation_and_Induces_Apoptosis_in_Chronic_Lymphocytic_Leukemia_B_Cells/22451252/1/files/39902336.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361908950.pdf","grobid_xml":"https://content.openalex.org/works/W4361908950.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2121676675","https://openalex.org/W2581703858","https://openalex.org/W2557180286","https://openalex.org/W2568586361","https://openalex.org/W4361883033","https://openalex.org/W4361908950","https://openalex.org/W4361882927","https://openalex.org/W4361908639","https://openalex.org/W2552681822","https://openalex.org/W2153514145"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"69KB,":[3],"MLN4924-induces":[4],"apoptosis":[5,75],"of":[6,15,51,80],"the":[7,64,71,78],"CLL":[8,24,88],"B-cells":[9],"on":[10,28],"CD40L-expressing":[11,29],"stroma":[12,30],"is":[13],"independent":[14],"IGHV":[16],"mutational":[17],"status":[18],"(A)":[19],"and":[20,58,61],"cytogenetics":[21],"(B,":[22],"C).":[23],"cells":[25,52],"were":[26],"cultured":[27],"for":[31,44],"24":[32],"hours,":[33],"followed":[34],"by":[35,55],"incubation":[36],"with":[37],"1":[38],"\u03bcM":[39],"MLN4924":[40],"or":[41],"vehicle":[42],"control":[43],"48":[45],"hours.":[46],"Apoptosis":[47],"within":[48],"CD19+":[49],"subset":[50],"was":[53],"determined":[54],"Annexin":[56],"V":[57],"7-AAD":[59],"staining":[60],"normalized":[62],"to":[63],"time-matched":[65],"untreated":[66],"controls.":[67],"Horizontal":[68],"lines":[69],"represent":[70],"mean.":[72],"(C)":[73],"%":[74],"plotted":[76],"against":[77],"size":[79],"a":[81],"17p":[82],"deletion":[83],"clone":[84],"in":[85],"11":[86],"individual":[87],"samples":[89],"(r=-0.2,":[90],"p=0.56).":[91]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}
