{"id":"https://openalex.org/W4361908883","doi":"https://doi.org/10.1158/1078-0432.22451843.v1","title":"Supplementary Figures 1-4 from MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls","display_name":"Supplementary Figures 1-4 from MicroRNA Array Analysis Finds Elevated Serum miR-1290 Accurately Distinguishes Patients with Low-Stage Pancreatic Cancer from Healthy and Disease Controls","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361908883","doi":"https://doi.org/10.1158/1078-0432.22451843.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22451843.v1","doi":"https://doi.org/10.1158/1078-0432.22451843.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451843.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39902918","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://aacr.figshare.com/ndownloader/files/39902918","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ang Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ang Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100614702","display_name":"Jun Qing Yu","orcid":"https://orcid.org/0000-0001-5008-2153","observed_orcids":["https://orcid.org/0000-0001-5008-2153"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Yu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032641605","display_name":"Haeryoung Kim","orcid":"https://orcid.org/0000-0002-4205-9081","observed_orcids":["https://orcid.org/0000-0002-4205-9081"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haeryoung Kim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103031010","display_name":"Christopher Lee Wolfgang","orcid":"https://orcid.org/0000-0002-8717-0373","observed_orcids":["https://orcid.org/0000-0002-8717-0373","https://orcid.org/0009-0000-5817-6146"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher L. Wolfgang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039731184","display_name":"Marcia Irene Canto","orcid":"https://orcid.org/0000-0002-2193-3032","observed_orcids":["https://orcid.org/0000-0002-2193-3032"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcia Irene Canto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001682484","display_name":"Ralph H. Hruban","orcid":"https://orcid.org/0000-0003-4554-5672","observed_orcids":["https://orcid.org/0000-0003-4554-5672"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ralph H. Hruban","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5090286753","display_name":"Michael Goggins","orcid":"https://orcid.org/0000-0002-4286-2296","observed_orcids":["https://orcid.org/0000-0002-4286-2296"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Goggins","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9868000149726868,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.00839999970048666,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/serum-mirna","display_name":"serum microRNA","score":0.7609999775886536},{"id":"https://openalex.org/keywords/mir-1290","display_name":"miR-1290","score":0.9990000128746033},{"id":"https://openalex.org/keywords/diagnostic-biomarkers","display_name":"diagnostic biomarkers","score":0.7319999933242798},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.9129999876022339},{"id":"https://openalex.org/keywords/chronic-pancreatitis","display_name":"chronic pancreatitis","score":1.0},{"id":"https://openalex.org/keywords/microrna-expression-profiling","display_name":"miRNA expression profiling","score":0.6710000038146973},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6840000152587891},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.9300000071525574},{"id":"https://openalex.org/keywords/aspc-1-cells","display_name":"AsPC-1 cells","score":0.703000009059906},{"id":"https://openalex.org/keywords/panc-1-cells","display_name":"PANC-1 cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.44699999690055847}],"concepts":[{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.8039318323135376},{"id":"https://openalex.org/C2775967933","wikidata":"https://www.wikidata.org/wiki/Q1527888","display_name":"Pancreatitis","level":2,"score":0.7696937918663025},{"id":"https://openalex.org/C143660080","wikidata":"https://www.wikidata.org/wiki/Q7684883","display_name":"TaqMan","level":4,"score":0.7624359726905823},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6068814396858215},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5398444533348083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5209073424339294},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4615054428577423},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4441063404083252},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.2920878529548645},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2588587999343872},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22451843.v1","doi":"https://doi.org/10.1158/1078-0432.22451843.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451843.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39902918","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22451843","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figures_1-4_from_MicroRNA_Array_Analysis_Finds_Elevated_Serum_miR-1290_Accurately_Distinguishes_Patients_with_Low-Stage_Pancreatic_Cancer_from_Healthy_and_Disease_Controls/22451843","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22451843.v1","doi":"https://doi.org/10.1158/1078-0432.22451843.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451843.v1","pdf_url":"https://aacr.figshare.com/ndownloader/files/39902918","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361908883.pdf","grobid_xml":"https://content.openalex.org/works/W4361908883.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2351639052","https://openalex.org/W1546736424","https://openalex.org/W1486759846","https://openalex.org/W2352440946","https://openalex.org/W2374065674","https://openalex.org/W2047983645","https://openalex.org/W3145873378","https://openalex.org/W3030550923","https://openalex.org/W2552414513","https://openalex.org/W2025542867"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"818K,":[3],"Supplemental":[4,89,125,247],"Figure":[5,90,126,248],"S1":[6],"(A)":[7,97],"A":[8,98],"3D":[9],"Principal":[10],"component":[11],"analysis":[12],"(PCA)":[13],"plot":[14],"of":[15,28,57,93,116,129,140,150,182,252,265,290,333,339,347,372,377,383],"the":[16,21,25,55,58,106,179,214,218,221,227,358,364],"miRNA":[17,95,317],"data":[18],"that":[19],"characterizes":[20],"trends":[22],"exhibited":[23],"by":[24,122],"expression":[26,263],"profiles":[27],"pancreatic":[29,33,77,137,157,164,198,255],"cancer":[30,78,158,195,256],"(PC,":[31],"purple),":[32],"neuroendocrine":[34,165,199],"tumor":[35,166],"(NET,":[36,85],"green),":[37],"chronic":[38,170,186,201],"pancreatitis":[39,171,187],"(CP,":[40],"red)),":[41],"healthy":[42],"controls":[43,153,175,184,190,205],"(N,":[44],"blue).":[45],"Each":[46],"dot":[47],"represents":[48,54],"a":[49,313,352],"sample":[50,100],"and":[51,74,87,105,152,169,178,188,193,203,217,229,259,273,275,279,294,301,308,316,319,336,374],"each":[52],"color":[53],"type":[56],"sample.":[59],"(B)":[60,113],"VENN":[61],"diagram":[62],"showing":[63],"significantly":[64],"elevated":[65,130],"miRNAs":[66,131],"(fold-change":[67],"less":[68],"than":[69],"or":[70],"equal":[71],"to":[72,81,161,243],"2":[73,246],"p<0.05)":[75],"in":[76,103,132,146,269,357,363],"(PC)":[79],"compared":[80,145,160],"three":[82],"control":[83,196],"groups":[84],"CP,":[86],"N).":[88],"S2":[91],"Reproducibility":[92],"Taqman":[94,123,209],"microarray.":[96],"serum":[99,119,133,142],"was":[101,108,233,241,322,349],"analyzed":[102],"duplicate":[104],"correlation":[107],"determined":[109,323,350],"using":[110,208,324,351],"Spearman":[111],"test.":[112],"The":[114,250,262,344],"effects":[115,251],"pre-amplification":[117],"on":[118,254],"miR-1290":[120,253,266,270,276,299,306,314,348],"levels":[121,264,289],"RT-PCR.":[124],"S3":[127],"Validation":[128],"from":[134,181],"patients":[135,155,162],"with":[136,156,163,298,304,312],"cancer.":[138],"Levels":[139],"selected":[141],"microRNAs":[143],"were":[144,267,296,310,386],"an":[147],"independent":[148,341,379],"set":[149],"cases":[151],"including":[154,185,197],"(n=41)":[159],"(NET)":[167],"(n=18)":[168],"(CP)":[172],"(n=35),":[173],"normal":[174,189,204],"(N)":[176],"(n=19),":[177],"combined":[180],"non-malignant":[183],"(CN)":[191],"(n=54),":[192],"non-pancreatic":[194],"tumor,":[200],"pancreatitis,":[202],"(NCN)":[206],"(n=72)":[207],"real-time":[210],"PCR.":[211],"Boxes":[212],"represent":[213],"inter-quartile":[215],"range":[216],"line":[219],"indicates":[220],"median":[222],"value.":[223],"Error":[224],"bars":[225],"indicate":[226],"90th":[228],"10th":[230],"percentiles.":[231],"MiR-16":[232],"used":[234,242],"as":[235],"reference":[236],"gene":[237],"for":[238],"normalization.":[239],"Mann-Whitney":[240],"compare":[244],"groups.":[245],"S4":[249],"cell":[257,281,302,320,360],"proliferation":[258],"invasion.":[260],"(A).":[261],"measured":[268],"mimic-transfected":[271],"AsPC1":[272],"Panc5.04":[274],"inhibitor-transfected":[277],"Panc10.05":[278],"Panc198":[280],"lines,":[282],"respectively.":[283,327],"(B).":[284],"Cell":[285],"lines":[286,303,361],"expressing":[287],"low":[288],"miR":[291],"1290":[292],"(AsPC1":[293],"Panc5.04)":[295],"transfected":[297,311],"mimic":[300],"high":[305],"(Panc10.05":[307],"Panc198)":[309],"inhibitor":[315],"controls,":[318],"growth":[321],"MTS":[325],"assay,":[326],"Data":[328,367],"are":[329,337,368,375],"mean":[330,369],"+/-":[331,370],"SD":[332,371],"5":[334],"replicates":[335],"representative":[338,376],"two":[340,378],"experiments.":[342,380],"(C).":[343],"invasive":[345],"potential":[346],"chamber":[353],"matrigel":[354],"invasion":[355,384],"assay":[356],"same":[359,365],"treated":[362],"way.":[366],"triplicates":[373],"Representative":[381],"photographs":[382],"assays":[385],"shown":[387],"(D).":[388],"Original":[389],"magnification,":[390],"20x.":[391]},"counts_by_year":[],"updated_date":"2026-10-05T09:50:58.205359","created_date":"2025-10-10T00:00:00"}