{"id":"https://openalex.org/W4361908560","doi":"https://doi.org/10.1158/1078-0432.22451054.v1","title":"Supplementary Methods from Notch Pathway Activity Identifies Cells with Cancer Stem Cell\u2013like Properties and Correlates with Worse Survival in Lung Adenocarcinoma","display_name":"Supplementary Methods from Notch Pathway Activity Identifies Cells with Cancer Stem Cell\u2013like Properties and Correlates with Worse Survival in Lung Adenocarcinoma","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361908560","doi":"https://doi.org/10.1158/1078-0432.22451054.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22451054.v1","doi":"https://doi.org/10.1158/1078-0432.22451054.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451054.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22451054.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056827435","display_name":"Khaled Aref Hassan","orcid":"https://orcid.org/0000-0001-5553-5051","observed_orcids":["https://orcid.org/0000-0001-5553-5051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Khaled A. Hassan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100368252","display_name":"Luo Wang","orcid":"https://orcid.org/0000-0003-0013-1409","observed_orcids":["https://orcid.org/0000-0003-0013-1409"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Luo Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037279132","display_name":"Hasan K\u00f6rkaya","orcid":"https://orcid.org/0000-0002-0719-5862","observed_orcids":["https://orcid.org/0000-0002-0719-5862"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hasan Korkaya","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001276721","display_name":"Guoan Chen","orcid":"https://orcid.org/0000-0001-5608-6761","observed_orcids":["https://orcid.org/0000-0001-5608-6761"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guoan Chen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048706550","display_name":"Ivan P. Maillard","orcid":"https://orcid.org/0000-0003-1312-6748","observed_orcids":["https://orcid.org/0000-0003-1312-6748"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ivan Maillard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057943415","display_name":"David G. Beer","orcid":"https://orcid.org/0000-0002-2662-9507","observed_orcids":["https://orcid.org/0000-0002-2662-9507"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G. Beer","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066306817","display_name":"Gregory Peter Kalemkerian","orcid":"https://orcid.org/0000-0003-2404-7420","observed_orcids":["https://orcid.org/0000-0003-2404-7420"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory P. Kalemkerian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5059956218","display_name":"Max S. Wicha","orcid":"https://orcid.org/0000-0003-4180-7727","observed_orcids":["https://orcid.org/0000-0003-4180-7727"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Max S. Wicha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9082000255584717,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.05810000002384186,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9570000171661377},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lung-adenocarcinoma","display_name":"lung adenocarcinoma","score":0.9929999709129333},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.5640000104904175},{"id":"https://openalex.org/keywords/immunohistochemistry","display_name":"immunohistochemistry","score":0.890999972820282},{"id":"https://openalex.org/keywords/pcr-assay","display_name":"PCR testing","score":0.6370000243186951}],"concepts":[{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.7121641635894775},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.7059517502784729},{"id":"https://openalex.org/C161879069","wikidata":"https://www.wikidata.org/wiki/Q904082","display_name":"Notch signaling pathway","level":3,"score":0.6940983533859253},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6335935592651367},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.527214765548706},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4991636276245117},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.49693563580513},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4541572332382202},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4355420768260956},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.4317353367805481},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4283989667892456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.424262672662735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37489327788352966},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3639753460884094},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3121844530105591},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.24077686667442322},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.14161208271980286},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12982100248336792}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22451054.v1","doi":"https://doi.org/10.1158/1078-0432.22451054.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451054.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22451054","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Methods_from_Notch_Pathway_Activity_Identifies_Cells_with_Cancer_Stem_Cell_like_Properties_and_Correlates_with_Worse_Survival_in_Lung_Adenocarcinoma/22451054","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22451054.v1","doi":"https://doi.org/10.1158/1078-0432.22451054.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22451054.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2068425472","https://openalex.org/W2007921174","https://openalex.org/W2041309570","https://openalex.org/W2313747319","https://openalex.org/W2043209260","https://openalex.org/W2034458870","https://openalex.org/W1985987709","https://openalex.org/W3094249402","https://openalex.org/W4237029557","https://openalex.org/W1965060648"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"84K,":[3],"Immunohistochemistry":[4],"and":[5],"PCR":[6],"assays":[7],"methodology.":[8]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2025-10-10T00:00:00"}