{"id":"https://openalex.org/W4361908549","doi":"https://doi.org/10.1158/1078-0432.22451111.v1","title":"Supplementary Methods and Materials and Supplementary Figures 1-2 from Phase I Study of U3-1287, a Fully Human Anti-HER3 Monoclonal Antibody, in Patients with Advanced Solid Tumors","display_name":"Supplementary Methods and Materials and Supplementary Figures 1-2 from Phase I Study of U3-1287, a Fully Human Anti-HER3 Monoclonal Antibody, in Patients with Advanced Solid Tumors","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361908549","doi":"https://doi.org/10.1158/1078-0432.22451111.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22451111.v1","doi":"https://doi.org/10.1158/1078-0432.22451111.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451111.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.22451111.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064953304","display_name":"Patricia Mucci LoRusso","orcid":"https://orcid.org/0000-0001-7144-036X","observed_orcids":["https://orcid.org/0000-0001-7144-036X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Patricia LoRusso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048675362","display_name":"Pasi Antero Janne","orcid":"https://orcid.org/0000-0002-7821-4928","observed_orcids":["https://orcid.org/0000-0002-7821-4928"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pasi A. J\u00e4nne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021912190","display_name":"Moacyr Ribeiro de Oliveira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Moacyr Oliveira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075877134","display_name":"Naiyer A. Rizvi","orcid":"https://orcid.org/0000-0002-1134-7494","observed_orcids":["https://orcid.org/0000-0002-1134-7494"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Naiyer Rizvi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086264495","display_name":"Lisa Malburg","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa Malburg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087055974","display_name":"Vicki Leigh Keedy","orcid":"https://orcid.org/0000-0002-7213-7562","observed_orcids":["https://orcid.org/0000-0002-7213-7562"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vicki Keedy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088473266","display_name":"Lorrin Yee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lorrin Yee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077011628","display_name":"Catherine Copigneaux","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Copigneaux","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000950844","display_name":"Thore Hettmann","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thore Hettmann","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102508030","display_name":"Chi\u2010Yuan Wu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chi-Yuan Wu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010370929","display_name":"Agnes Lee Ang","orcid":"https://orcid.org/0000-0002-0325-9099","observed_orcids":["https://orcid.org/0000-0002-0325-9099"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnes Ang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101653474","display_name":"Abdel\u2010Baset Halim","orcid":"https://orcid.org/0000-0002-3640-7027","observed_orcids":["https://orcid.org/0000-0002-3640-7027"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdel-Baset Halim","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027438799","display_name":"Robert A. Beckman","orcid":"https://orcid.org/0000-0003-0098-9210","observed_orcids":["https://orcid.org/0000-0003-0098-9210"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert A. Beckman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002011167","display_name":"Darrin M. Beaupre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Darrin Beaupre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5039492614","display_name":"Jordan D. Berlin","orcid":"https://orcid.org/0000-0001-7571-2385","observed_orcids":["https://orcid.org/0000-0001-7571-2385"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan Berlin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anti-her3-monoclonal-antibody","display_name":"anti-HER3 monoclonal antibody","score":0.9819999933242798},{"id":"https://openalex.org/keywords/her3","display_name":"HER3","score":0.9340000152587891},{"id":"https://openalex.org/keywords/advanced-solid-tumors","display_name":"advanced solid tumors","score":0.8069999814033508},{"id":"https://openalex.org/keywords/qtc-prolongation","display_name":"QTc prolongation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cardiac-safety","display_name":"cardiac safety","score":0.6100000143051147},{"id":"https://openalex.org/keywords/serum-drug-levels","display_name":"serum drug concentration","score":0.7620000243186951},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.871999979019165}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6635228991508484},{"id":"https://openalex.org/C2993640289","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Solid tumor","level":3,"score":0.5304312705993652},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.5161705613136292},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.508948802947998},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4110589325428009},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4102194905281067},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3600505590438843},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3469001054763794},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3439905047416687},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30619025230407715},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22739896178245544},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1651458442211151},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.062427788972854614}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22451111.v1","doi":"https://doi.org/10.1158/1078-0432.22451111.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451111.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22451111","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Methods_and_Materials_and_Supplementary_Figures_1-2_from_Phase_I_Study_of_U3-1287_a_Fully_Human_Anti-HER3_Monoclonal_Antibody_in_Patients_with_Advanced_Solid_Tumors/22451111","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22451111.v1","doi":"https://doi.org/10.1158/1078-0432.22451111.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22451111.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W1999686187","https://openalex.org/W2049834980","https://openalex.org/W2340284051","https://openalex.org/W1969822711","https://openalex.org/W2073840950","https://openalex.org/W2019666956","https://openalex.org/W2063428357","https://openalex.org/W4293213287"],"abstract_inverted_index":{"PDF":[0],"-":[1,13,24],"278K,":[2],"Supplementary":[3,10,21],"Methods":[4],"and":[5],"Materials,":[6],"QTc":[7,14],"prolongation":[8,15],"results.":[9],"Figure":[11,22],"1":[12],"compared":[16],"with":[17],"serum":[18],"U3-1287":[19],"concentration.":[20],"2":[23],"U3-1287-mediated":[25],"pancreatic":[26],"xenograft":[27],"growth":[28],"inhibition)":[29]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}
