{"id":"https://openalex.org/W4361908487","doi":"https://doi.org/10.1158/1078-0432.22450815.v1","title":"Supplementary Figure 1 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel","display_name":"Supplementary Figure 1 from Electrocardiographic Studies of Romidepsin Demonstrate Its Safety and Identify a Potential Role for KATP Channel","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361908487","doi":"https://doi.org/10.1158/1078-0432.22450815.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22450815.v1","doi":"https://doi.org/10.1158/1078-0432.22450815.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22450815.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/1078-0432.22450815.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009849305","display_name":"Anne M. Noonan","orcid":"https://orcid.org/0000-0001-8083-8492","observed_orcids":["https://orcid.org/0000-0001-8083-8492"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anne M. Noonan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109602040","display_name":"Robin A. Eisch","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robin A. Eisch","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063126623","display_name":"David J. Liewehr","orcid":"https://orcid.org/0000-0002-1039-7713","observed_orcids":["https://orcid.org/0000-0002-1039-7713"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Liewehr","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045610944","display_name":"Tristan M. Sissung","orcid":"https://orcid.org/0000-0002-3684-5377","observed_orcids":["https://orcid.org/0000-0002-3684-5377"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tristan M. Sissung","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024024043","display_name":"David J. Venzon","orcid":"https://orcid.org/0000-0002-8990-158X","observed_orcids":["https://orcid.org/0000-0002-8990-158X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David J. Venzon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034651772","display_name":"Thomas P. Flagg","orcid":"https://orcid.org/0000-0002-3147-4060","observed_orcids":["https://orcid.org/0000-0002-3147-4060"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas P. Flagg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003195419","display_name":"Mark C. Haigney","orcid":"https://orcid.org/0000-0001-6449-4386","observed_orcids":["https://orcid.org/0000-0001-6449-4386"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark C. Haigney","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044239219","display_name":"Seth M. Steinberg","orcid":"https://orcid.org/0000-0002-8280-551X","observed_orcids":["https://orcid.org/0000-0002-8280-551X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seth M. Steinberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079418869","display_name":"William Douglas Figg","orcid":"https://orcid.org/0000-0003-2428-5613","observed_orcids":["https://orcid.org/0000-0003-2428-5613"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"William D. Figg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046042179","display_name":"Richard Piekarz","orcid":"https://orcid.org/0000-0002-3591-7893","observed_orcids":["https://orcid.org/0000-0002-3591-7893"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard L. Piekarz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013592290","display_name":"Susan Elaine Bates","orcid":"https://orcid.org/0000-0001-6708-0330","observed_orcids":["https://orcid.org/0000-0001-6708-0330"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Susan E. Bates","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.8862000107765198,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11736","display_name":"Histone Deacetylase Inhibitors Research","score":0.06459999829530716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/romidepsin","display_name":"romidepsin","score":1.0},{"id":"https://openalex.org/keywords/electrocardiography","display_name":"electrocardiogram","score":0.8259999752044678},{"id":"https://openalex.org/keywords/heart-rate-changes","display_name":"heart rate changes","score":0.8140000104904175},{"id":"https://openalex.org/keywords/atp-sensitive-potassium-channels","display_name":"ATP-sensitive potassium channels","score":0.9160000085830688},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.7300000190734863},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2779578097","wikidata":"https://www.wikidata.org/wiki/Q1484058","display_name":"Short QT syndrome","level":4,"score":0.44540655612945557},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39502865076065063},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3418416380882263},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.3373016119003296},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.323056161403656},{"id":"https://openalex.org/C2779703243","wikidata":"https://www.wikidata.org/wiki/Q653924","display_name":"Long QT syndrome","level":3,"score":0.23173323273658752}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22450815.v1","doi":"https://doi.org/10.1158/1078-0432.22450815.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22450815.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22450815","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_1_from_Electrocardiographic_Studies_of_Romidepsin_Demonstrate_Its_Safety_and_Identify_a_Potential_Role_for_K_sub_ATP_sub_Channel/22450815","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22450815.v1","doi":"https://doi.org/10.1158/1078-0432.22450815.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/1078-0432.22450815.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2153116368","https://openalex.org/W1692709557","https://openalex.org/W2411617744","https://openalex.org/W2026770747","https://openalex.org/W2028280790","https://openalex.org/W2170615482","https://openalex.org/W947404255","https://openalex.org/W2737817678"],"abstract_inverted_index":{"Supplementary":[0],"Figure":[1],"1":[2,20],"-":[3],"PDF":[4],"file":[5],"69K,":[6],"Changes":[7],"in":[8,14],"heart":[9],"rate":[10],"observed":[11],"for":[12],"patients":[13],"the":[15],"NIH":[16],"cohort":[17],"during":[18],"cycle":[19],"days":[21],"1,":[22],"8":[23],"and":[24],"15":[25]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2025-10-10T00:00:00"}