{"id":"https://openalex.org/W4361908354","doi":"https://doi.org/10.1158/1078-0432.22450916.v1","title":"Supplementary Figure 4 from Hsa-miR-31-3p Expression Is Linked to Progression-free Survival in Patients with KRAS Wild-type Metastatic Colorectal Cancer Treated with Anti-EGFR Therapy","display_name":"Supplementary Figure 4 from Hsa-miR-31-3p Expression Is Linked to Progression-free Survival in Patients with KRAS Wild-type Metastatic Colorectal Cancer Treated with Anti-EGFR Therapy","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361908354","doi":"https://doi.org/10.1158/1078-0432.22450916.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22450916.v1","doi":"https://doi.org/10.1158/1078-0432.22450916.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22450916.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22450916.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044673409","display_name":"Gilles Manceau","orcid":"https://orcid.org/0000-0002-0783-8688","observed_orcids":["https://orcid.org/0000-0002-0783-8688"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gilles Manceau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022177128","display_name":"Sandrine Imbeaud","orcid":"https://orcid.org/0000-0001-8439-6732","observed_orcids":["https://orcid.org/0000-0001-8439-6732"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandrine Imbeaud","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007552034","display_name":"Rapha\u00eble Thi\u00e9baut","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rapha\u00eble Thi\u00e9baut","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045274199","display_name":"Fran\u00e7ois Li\u00e9baert","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fran\u00e7ois Li\u00e9baert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055523096","display_name":"Karine Fontaine","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karine Fontaine","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110270513","display_name":"Francis Rousseau","orcid":"https://orcid.org/0009-0002-5831-1322","observed_orcids":["https://orcid.org/0009-0002-5831-1322"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis Rousseau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083128484","display_name":"B\u00e9reng\u00e8re G\u00e9nin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B\u00e9reng\u00e8re G\u00e9nin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064362753","display_name":"Delphine Le Corre","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delphine Le Corre","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022507982","display_name":"Audrey Didelot","orcid":"https://orcid.org/0000-0001-8693-1612","observed_orcids":["https://orcid.org/0000-0001-8693-1612"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Audrey Didelot","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031402667","display_name":"Marc Vincent","orcid":"https://orcid.org/0000-0001-6921-8161","observed_orcids":["https://orcid.org/0000-0001-6921-8161"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marc Vincent","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061710022","display_name":"Jean\u2010Baptiste Bachet","orcid":"https://orcid.org/0000-0003-4337-286X","observed_orcids":["https://orcid.org/0000-0003-4337-286X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Baptiste Bachet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013525685","display_name":"Benoist Chibaudel","orcid":"https://orcid.org/0000-0003-1279-2044","observed_orcids":["https://orcid.org/0000-0003-1279-2044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Benoist Chibaudel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077000250","display_name":"Olivier Bouch\u00e9","orcid":"https://orcid.org/0000-0002-8284-3743","observed_orcids":["https://orcid.org/0000-0002-8284-3743"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olivier Bouch\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108447623","display_name":"Bruno Landi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bruno Landi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071021061","display_name":"Fr\u00e9d\u00e9ric Bibeau","orcid":"https://orcid.org/0000-0001-7126-1185","observed_orcids":["https://orcid.org/0000-0001-7126-1185"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9ric Bibeau","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057049022","display_name":"Karen Leroy","orcid":"https://orcid.org/0000-0002-4379-0140","observed_orcids":["https://orcid.org/0000-0002-4379-0140"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Karen Leroy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061340891","display_name":"Frederique Madeleine Penault-Llorca","orcid":"https://orcid.org/0000-0002-4279-5492","observed_orcids":["https://orcid.org/0000-0002-4279-5492"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fr\u00e9d\u00e9rique Penault-Llorca","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107940530","display_name":"Jean\u2013Luc Van Laethem","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jean-Luc Van Laethem","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085079548","display_name":"Pieter Demetter","orcid":"https://orcid.org/0000-0001-7981-4645","observed_orcids":["https://orcid.org/0000-0001-7981-4645"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pieter Demetter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027182289","display_name":"Sabine Tejpar","orcid":"https://orcid.org/0000-0003-3281-8643","observed_orcids":["https://orcid.org/0000-0003-3281-8643"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sabine Tejpar","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104272779","display_name":"Simona Rossi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simona Rossi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015441060","display_name":"Neda Mosakhani","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neda Mosakhani","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062725034","display_name":"Pia J. Osterlund","orcid":"https://orcid.org/0000-0002-7124-3515","observed_orcids":["https://orcid.org/0000-0002-7124-3515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pia \u00d6sterlund","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004247399","display_name":"Raija Ristam\u00e4ki","orcid":"https://orcid.org/0000-0001-6817-3045","observed_orcids":["https://orcid.org/0000-0001-6817-3045"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raija Ristam\u00e4ki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057304346","display_name":"Virinder Kaur Sarhadi","orcid":"https://orcid.org/0000-0003-2503-8198","observed_orcids":["https://orcid.org/0000-0003-2503-8198"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Virinder Sarhadi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076240896","display_name":"Sakari Knuutila","orcid":"https://orcid.org/0000-0001-5592-3839","observed_orcids":["https://orcid.org/0000-0001-5592-3839"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sakari Knuutila","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041492973","display_name":"Val\u00e9rie Boige","orcid":"https://orcid.org/0000-0002-7817-4663","observed_orcids":["https://orcid.org/0000-0002-7817-4663"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Val\u00e9rie Boige","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079480540","display_name":"Thierry Andr\u00e9","orcid":"https://orcid.org/0000-0002-5103-7095","observed_orcids":["https://orcid.org/0000-0002-5103-7095"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thierry Andr\u00e9","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5089818289","display_name":"Pierre Laurent\u2010Puig","orcid":"https://orcid.org/0000-0001-8475-5459","observed_orcids":["https://orcid.org/0000-0001-8475-5459"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pierre Laurent-Puig","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.875,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.11900000274181366,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna-expression","display_name":"microRNA expression","score":0.7289999723434448},{"id":"https://openalex.org/keywords/kras-wild-type","display_name":"KRAS wild-type","score":0.7730000019073486},{"id":"https://openalex.org/keywords/metastatic-colorectal-cancer","display_name":"metastatic colorectal cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/anti-egfr-therapy","display_name":"anti-EGFR therapy","score":0.996999979019165},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9390000104904175},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8610000014305115},{"id":"https://openalex.org/keywords/hazard-ratio","display_name":"hazard ratio","score":0.515999972820282}],"concepts":[{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.8401510715484619},{"id":"https://openalex.org/C21790070","wikidata":"https://www.wikidata.org/wiki/Q18030215","display_name":"Neuroblastoma RAS viral oncogene homolog","level":5,"score":0.7802013158798218},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6789766550064087},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.6740743517875671},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6651948094367981},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6069087386131287},{"id":"https://openalex.org/C76818968","wikidata":"https://www.wikidata.org/wiki/Q181940","display_name":"Sanger sequencing","level":4,"score":0.6018581986427307},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.6008195877075195},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.5807410478591919},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.45711755752563477},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.41848036646842957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3638150990009308},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.34579557180404663},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.216478168964386},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14976435899734497},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.1494142711162567},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08514922857284546},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22450916.v1","doi":"https://doi.org/10.1158/1078-0432.22450916.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22450916.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22450916","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_4_from_Hsa-miR-31-3p_Expression_Is_Linked_to_Progression-free_Survival_in_Patients_with_KRAS_Wild-type_Metastatic_Colorectal_Cancer_Treated_with_Anti-EGFR_Therapy/22450916","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22450916.v1","doi":"https://doi.org/10.1158/1078-0432.22450916.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22450916.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361944328","https://openalex.org/W2101499047","https://openalex.org/W2528007855","https://openalex.org/W2064643769","https://openalex.org/W1977916480","https://openalex.org/W2758868699","https://openalex.org/W1992052224","https://openalex.org/W2600730368","https://openalex.org/W3000288349","https://openalex.org/W4200198955"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"62KB,":[3],"Kaplan-Meier":[4],"PFS":[5],"according":[6],"to":[7],"level":[8],"of":[9,11,17,32],"expression":[10],"hsa-miR-31-3p":[12],"in":[13],"the":[14,21,37,46,58],"whole":[15],"series":[16],"132":[18],"patients.":[19],"For":[20],"102":[22],"patients":[23],"who":[24],"were":[25],"NRAS":[26],"wild-type":[27],"based":[28],"on":[29],"Sanger":[30],"sequencing":[31],"exon":[33],"2":[34],"and":[35,45,53,60],"3,":[36],"hazard":[38],"ratio":[39],"was":[40,51],"2.51":[41],"CI95":[42],"percent":[43],"(1.6-4)":[44],"median":[47],"progression":[48],"free":[49],"survival":[50],"10.14":[52],"35.71":[54],"weeks":[55],"respectively":[56],"for":[57],"high":[59],"low":[61],"risk":[62],"groups.":[63]},"counts_by_year":[],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2023-04-05T00:00:00"}