{"id":"https://openalex.org/W4361908129","doi":"https://doi.org/10.1158/1078-0432.22450355.v1","title":"Supplementary Figure 3 from Inactivation or Loss of TTP Promotes Invasion in Head and Neck Cancer via Transcript Stabilization and Secretion of MMP9, MMP2, and IL-6","display_name":"Supplementary Figure 3 from Inactivation or Loss of TTP Promotes Invasion in Head and Neck Cancer via Transcript Stabilization and Secretion of MMP9, MMP2, and IL-6","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361908129","doi":"https://doi.org/10.1158/1078-0432.22450355.v1"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.22450355.v1","doi":"https://doi.org/10.1158/1078-0432.22450355.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22450355.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/1078-0432.22450355.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084126289","display_name":"Elizabeth A. Van Tubergen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elizabeth A. Van Tubergen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070513305","display_name":"Rajat Banerjee","orcid":"https://orcid.org/0000-0003-2970-4901","observed_orcids":["https://orcid.org/0000-0003-2970-4901"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rajat Banerjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108047619","display_name":"Min Liu","orcid":"https://orcid.org/0000-0001-8115-5407","observed_orcids":["https://orcid.org/0000-0001-8115-5407","https://orcid.org/0000-0002-0438-7383"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Min Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051485664","display_name":"Robert Vander Broek","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Vander Broek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039655682","display_name":"Emily Light","orcid":"https://orcid.org/0009-0002-0272-9535","observed_orcids":["https://orcid.org/0009-0002-0272-9535"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Emily Light","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002444296","display_name":"Shiuhyang Kuo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shiuhyang Kuo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066838365","display_name":"Stephen E. Feinberg","orcid":"https://orcid.org/0000-0003-3292-8797","observed_orcids":["https://orcid.org/0000-0003-3292-8797"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen E. Feinberg","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033681453","display_name":"Amanda L. Willis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amanda L. Willis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083855375","display_name":"Gregory T. Wolf","orcid":"https://orcid.org/0000-0002-3219-9515","observed_orcids":["https://orcid.org/0000-0002-3219-9515"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gregory Wolf","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076508788","display_name":"Thomas E. Carey","orcid":"https://orcid.org/0000-0002-5202-7518","observed_orcids":["https://orcid.org/0000-0002-5202-7518"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Carey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040159243","display_name":"Carol Rossier Bradford","orcid":"https://orcid.org/0000-0002-2768-4532","observed_orcids":["https://orcid.org/0000-0002-2768-4532"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carol Bradford","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039039295","display_name":"Mark E. Prince","orcid":"https://orcid.org/0000-0002-1120-9008","observed_orcids":["https://orcid.org/0000-0002-1120-9008"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Prince","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022036818","display_name":"Francis Paul Worden","orcid":"https://orcid.org/0000-0002-6632-4951","observed_orcids":["https://orcid.org/0000-0002-6632-4951"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francis P. Worden","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074453161","display_name":"Keith Lough Kirkwood","orcid":"https://orcid.org/0000-0003-4519-8973","observed_orcids":["https://orcid.org/0000-0003-4519-8973"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Keith L. Kirkwood","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5017436055","display_name":"Nisha J. D\u2019Silva","orcid":"https://orcid.org/0000-0001-7030-3187","observed_orcids":["https://orcid.org/0000-0001-7030-3187"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nisha J. D'Silva","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.36329999566078186,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.36329999566078186,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.24789999425411224,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.11710000038146973,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ttp","display_name":"TTP","score":0.8870000243186951},{"id":"https://openalex.org/keywords/head-and-neck-squamous-cell-carcinoma","display_name":"head and neck squamous cell carcinoma","score":0.9049999713897705},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.8349999785423279},{"id":"https://openalex.org/keywords/chorioallantoic-membrane-assay","display_name":"chorioallantoic membrane assay","score":0.8360000252723694},{"id":"https://openalex.org/keywords/shrna-knockdown","display_name":"shRNA knockdown","score":0.7250000238418579},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":0.6029999852180481},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":1.0},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cell-invasion","display_name":"cell invasion","score":0.3619999885559082}],"concepts":[{"id":"https://openalex.org/C2777527632","wikidata":"https://www.wikidata.org/wiki/Q238382","display_name":"DAPI","level":3,"score":0.7142546772956848},{"id":"https://openalex.org/C2780699576","wikidata":"https://www.wikidata.org/wiki/Q15327913","display_name":"MMP2","level":4,"score":0.6629711985588074},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5861379504203796},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.4984018802642822},{"id":"https://openalex.org/C142613039","wikidata":"https://www.wikidata.org/wiki/Q272983","display_name":"Green fluorescent protein","level":3,"score":0.46098077297210693},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4306561052799225},{"id":"https://openalex.org/C91881484","wikidata":"https://www.wikidata.org/wiki/Q191807","display_name":"Fluorescence","level":2,"score":0.42963269352912903},{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.4223913252353668},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39213860034942627},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.34613239765167236},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2798525094985962},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.2699277102947235},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18158245086669922},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1650974452495575},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1557554304599762},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12760448455810547},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.09514284133911133},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.08402493596076965},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.06738629937171936},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.22450355.v1","doi":"https://doi.org/10.1158/1078-0432.22450355.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22450355.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22450355","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_3_from_Inactivation_or_Loss_of_TTP_Promotes_Invasion_in_Head_and_Neck_Cancer_via_Transcript_Stabilization_and_Secretion_of_MMP9_MMP2_and_IL-6/22450355","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/1078-0432.22450355.v1","doi":"https://doi.org/10.1158/1078-0432.22450355.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/1078-0432.22450355.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/14","display_name":"Life below water","score":0.8399999737739563}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361951029","https://openalex.org/W1990539408","https://openalex.org/W597740005","https://openalex.org/W1978968754","https://openalex.org/W2390500637","https://openalex.org/W2026753069","https://openalex.org/W6958696453","https://openalex.org/W2954982400","https://openalex.org/W6977197940","https://openalex.org/W1680992344"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"4209K,":[3],"Supplementary":[4],"Figure":[5],"S3":[6],"The":[7],"CAM":[8,25],"invasion":[9],"assay":[10],"was":[11],"performed":[12],"with":[13,42],"GFP":[14],"(green)":[15],"expressing":[16],"UM-SCC-1-shC":[17],"and":[18,38,46,57],"-shTTP":[19],"cells":[20],"placed":[21],"onto":[22],"the":[23],"upper":[24],"of":[26,62],"an":[27],"11-day-old":[28],"chick":[29],"embryo":[30],"for":[31],"two":[32],"days.":[33],"Tissue":[34],"sections":[35],"were":[36,40,50],"prepared":[37],"specimens":[39],"stained":[41],"Collagen":[43],"IV":[44],"(red)":[45],"DAPI":[47],"(blue).":[48],"Images":[49],"taken":[51],"on":[52],"Olympus":[53],"BX-51":[54],"fluorescent":[55],"microscope":[56],"merged.":[58],"Results":[59],"are":[60],"representative":[61],"3":[63],"independent":[64],"experiments.":[65],"White":[66],"arrows":[67],"point":[68],"to":[69],"invasive":[70],"islands.":[71]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2023-04-05T00:00:00"}
