{"id":"https://openalex.org/W4361898705","doi":"https://doi.org/10.1158/0008-5472.22423295.v1","title":"Supplementary Data from IRE1\u03b1 Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment","display_name":"Supplementary Data from IRE1\u03b1 Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361898705","doi":"https://doi.org/10.1158/0008-5472.22423295.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22423295.v1","doi":"https://doi.org/10.1158/0008-5472.22423295.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22423295.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22423295.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043204412","display_name":"Jonathan M. Harnoss","orcid":"https://orcid.org/0000-0002-4272-5769","observed_orcids":["https://orcid.org/0000-0002-4272-5769","https://orcid.org/0000-0003-0885-1347"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan M. Harnoss","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083160268","display_name":"Adrien Le Thomas","orcid":"https://orcid.org/0000-0002-9526-3916","observed_orcids":["https://orcid.org/0000-0002-9526-3916"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adrien Le Thomas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050078182","display_name":"Mike Reichelt","orcid":"https://orcid.org/0000-0003-1623-3733","observed_orcids":["https://orcid.org/0000-0003-1623-3733"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mike Reichelt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026691247","display_name":"Ofer Guttman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ofer Guttman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022934719","display_name":"Thomas D. Wu","orcid":"https://orcid.org/0000-0003-4505-4531","observed_orcids":["https://orcid.org/0000-0003-4505-4531"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas D. Wu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4505-4531","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078372515","display_name":"Scot A. Marsters","orcid":"https://orcid.org/0000-0002-8517-0994","observed_orcids":["https://orcid.org/0000-0002-8517-0994"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Scot A. Marsters","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024953477","display_name":"Anna Shemorry","orcid":"https://orcid.org/0000-0002-5797-3116","observed_orcids":["https://orcid.org/0000-0002-5797-3116"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Shemorry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"David A. Lawrence","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David A. Lawrence","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084542555","display_name":"David Kan","orcid":"https://orcid.org/0009-0008-0636-3124","observed_orcids":["https://orcid.org/0009-0008-0636-3124"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Kan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112147267","display_name":"Ehud Segal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ehud Segal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070894033","display_name":"Mark A. Merchant","orcid":"https://orcid.org/0000-0003-0690-8581","observed_orcids":["https://orcid.org/0000-0003-0690-8581"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Merchant","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009606169","display_name":"Kl\u00e1ra T\u00f3tp\u00e1l","orcid":"https://orcid.org/0000-0001-6629-6623","observed_orcids":["https://orcid.org/0000-0001-6629-6623"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Klara Totpal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050813261","display_name":"Lisa Crocker","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa M. Crocker","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069578028","display_name":"Kathryn Mesh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kathryn Mesh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056097513","display_name":"Monika Dohse","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Monika Dohse","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001356406","display_name":"Margaret Solon","orcid":"https://orcid.org/0000-0002-3998-0881","observed_orcids":["https://orcid.org/0000-0002-3998-0881"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Margaret Solon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074916693","display_name":"Zora D. Modrusan","orcid":"https://orcid.org/0009-0003-5647-5195","observed_orcids":["https://orcid.org/0009-0003-5647-5195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zora Modrusan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Joachim Rudolph","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joachim Rudolph","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040064532","display_name":"Hartmut Koeppen","orcid":"https://orcid.org/0000-0003-0923-3110","observed_orcids":["https://orcid.org/0000-0003-0923-3110"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hartmut Koeppen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087493059","display_name":"Peter Walter","orcid":"https://orcid.org/0000-0002-6849-708X","observed_orcids":["https://orcid.org/0000-0002-6849-708X","https://orcid.org/0000-0001-8745-6593"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Peter Walter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5028133447","display_name":"Avi Ashkenazi","orcid":"https://orcid.org/0000-0002-6890-4589","observed_orcids":["https://orcid.org/0000-0002-6890-4589"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Avi Ashkenazi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ire1alpha","display_name":"IRE1\u03b1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.9850000143051147},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.6840000152587891},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.8999999761581421}],"concepts":[{"id":"https://openalex.org/C2780110267","wikidata":"https://www.wikidata.org/wiki/Q7843332","display_name":"Triple-negative breast cancer","level":4,"score":0.7934143543243408},{"id":"https://openalex.org/C2781085045","wikidata":"https://www.wikidata.org/wiki/Q7318308","display_name":"Reversing","level":2,"score":0.7629927396774292},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.5470148921012878},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.4746033549308777},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4286019206047058},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4238084852695465},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4050880968570709},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3837910592556},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.333680659532547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2276136875152588},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.19379055500030518},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0733327865600586},{"id":"https://openalex.org/C171146098","wikidata":"https://www.wikidata.org/wiki/Q124192","display_name":"Automotive engineering","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1158/0008-5472.22423295.v1","doi":"https://doi.org/10.1158/0008-5472.22423295.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22423295.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22423295","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Data_from_IRE1_Disruption_in_Triple-Negative_Breast_Cancer_Cooperates_with_Antiangiogenic_Therapy_by_Reversing_ER_Stress_Adaptation_and_Remodeling_the_Tumor_Microenvironment/22423295","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22423295.v1","doi":"https://doi.org/10.1158/0008-5472.22423295.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22423295.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.75}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W1901129140","https://openalex.org/W2003171404","https://openalex.org/W2096441981","https://openalex.org/W2127911529","https://openalex.org/W2130455044","https://openalex.org/W2474869522","https://openalex.org/W2762788845","https://openalex.org/W2792837471","https://openalex.org/W2885058366","https://openalex.org/W2900391927","https://openalex.org/W2952240309","https://openalex.org/W2964808218","https://openalex.org/W2971237125"],"related_works":["https://openalex.org/W2354780065","https://openalex.org/W3011985225","https://openalex.org/W2482155543","https://openalex.org/W2475618665","https://openalex.org/W4224280204","https://openalex.org/W2380977331","https://openalex.org/W2373606770","https://openalex.org/W1995189325","https://openalex.org/W2885769062","https://openalex.org/W2374738829"],"abstract_inverted_index":{"Supplementary":[0,3,9],"Data,":[1,10],"including":[2,16],"Materials":[4],"and":[5,11],"Methods,":[6],"References":[7],"for":[8],"Figs.":[12],"S1":[13],"to":[14],"S5":[15],"Figure":[17],"Legends":[18]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}