{"id":"https://openalex.org/W4361897249","doi":"https://doi.org/10.1158/0008-5472.22413068.v1","title":"Supplementary Figure S1 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP","display_name":"Supplementary Figure S1 from ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP","publication_year":2023,"publication_date":"2023-03-31","ids":{"openalex":"https://openalex.org/W4361897249","doi":"https://doi.org/10.1158/0008-5472.22413068.v1"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22413068.v1","doi":"https://doi.org/10.1158/0008-5472.22413068.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22413068.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1158/0008-5472.22413068.v1","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046490043","display_name":"Taru E. Muranen","orcid":"https://orcid.org/0000-0003-4158-9002","observed_orcids":["https://orcid.org/0000-0003-4158-9002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Taru Muranen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043214812","display_name":"Laura M. Selfors","orcid":"https://orcid.org/0000-0002-1317-7353","observed_orcids":["https://orcid.org/0000-0002-1317-7353"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura M. Selfors","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071945498","display_name":"Julie Chernov Hwang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Julie Hwang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047346799","display_name":"Lisa L. Gallegos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa L. Gallegos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026521984","display_name":"Jonathan L. Coloff","orcid":"https://orcid.org/0000-0003-4726-3097","observed_orcids":["https://orcid.org/0000-0003-4726-3097"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan L. Coloff","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016604512","display_name":"Carson C. Thoreen","orcid":"https://orcid.org/0000-0003-1164-7224","observed_orcids":["https://orcid.org/0000-0003-1164-7224"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carson C. Thoreen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005864661","display_name":"Seong Anthony Woo Kang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seong A. Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013582936","display_name":"David M. Sabatini","orcid":"https://orcid.org/0000-0002-1446-7256","observed_orcids":["https://orcid.org/0000-0002-1446-7256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David M. Sabatini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon Brent Mills","orcid":"https://orcid.org/0000-0002-0144-9614","observed_orcids":["https://orcid.org/0000-0002-0144-9614"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gordon B. Mills","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5043845770","display_name":"Joan S. Brugge","orcid":"https://orcid.org/0000-0002-2547-4814","observed_orcids":["https://orcid.org/0000-0002-2547-4814"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joan S. Brugge","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-mtor-inhibitors","display_name":"PI3K/mTOR inhibitors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.8050000071525574},{"id":"https://openalex.org/keywords/erk","display_name":"ERK","score":0.5580000281333923},{"id":"https://openalex.org/keywords/p38-mapk","display_name":"p38 MAPK","score":0.996999979019165},{"id":"https://openalex.org/keywords/c-myc","display_name":"c-Myc","score":0.9760000109672546},{"id":"https://openalex.org/keywords/yap","display_name":"YAP","score":1.0},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pi3k-mtor-signaling","display_name":"PI3K/mTOR signaling","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.8945567011833191},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.7035266160964966},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5087361931800842},{"id":"https://openalex.org/C51551487","wikidata":"https://www.wikidata.org/wiki/Q2043632","display_name":"p38 mitogen-activated protein kinases","level":4,"score":0.4974727928638458},{"id":"https://openalex.org/C183713625","wikidata":"https://www.wikidata.org/wiki/Q5282002","display_name":"Discovery and development of mTOR inhibitors","level":4,"score":0.4605400264263153},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39943569898605347},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36698976159095764},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2695431709289551},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23710432648658752},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.13452044129371643}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.22413068.v1","doi":"https://doi.org/10.1158/0008-5472.22413068.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22413068.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22413068.v1","doi":"https://doi.org/10.1158/0008-5472.22413068.v1","is_oa":true,"landing_page_url":"https://doi.org/10.1158/0008-5472.22413068.v1","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4361875586","https://openalex.org/W4361823797","https://openalex.org/W2534634819","https://openalex.org/W1985880700","https://openalex.org/W2306111053","https://openalex.org/W2612152098","https://openalex.org/W3098031847","https://openalex.org/W2165864070","https://openalex.org/W2335232153","https://openalex.org/W2008984728"],"abstract_inverted_index":{"Structurally":[0],"diverse":[1],"PI3K/mTOR":[2],"inhibitors":[3],"induce":[4],"MYC":[5],"and":[6],"YAP":[7],"up-regulation":[8],"in":[9],"resistant":[10],"MCAS-R":[11],"cells.":[12]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2023-04-05T00:00:00"}