{"id":"https://openalex.org/W4361895906","doi":"https://doi.org/10.1158/0008-5472.22401138","title":"Supplementary Figure 5 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells","display_name":"Supplementary Figure 5 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells","publication_year":2023,"publication_date":"2023-03-30","ids":{"openalex":"https://openalex.org/W4361895906","doi":"https://doi.org/10.1158/0008-5472.22401138"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.22401138","doi":"https://doi.org/10.1158/0008-5472.22401138","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22401138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"volume":null,"type":"supplementary-materials","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://dx.doi.org/10.1158/0008-5472.22401138","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102876366","display_name":"Shruti Lal","orcid":"https://orcid.org/0009-0008-4517-3147","observed_orcids":["https://orcid.org/0009-0008-4517-3147","https://orcid.org/0000-0002-2091-4307"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shruti Lal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039843730","display_name":"Richard Andrew Burkhart","orcid":"https://orcid.org/0000-0003-1087-0870","observed_orcids":["https://orcid.org/0000-0003-1087-0870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard A. Burkhart","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056366467","display_name":"Neil Beeharry","orcid":"https://orcid.org/0000-0002-9495-8388","observed_orcids":["https://orcid.org/0000-0002-9495-8388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Neil Beeharry","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088935250","display_name":"Vikram Bhattacharjee","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vikram Bhattacharjee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047890254","display_name":"Eric R. Londin","orcid":"https://orcid.org/0000-0003-4331-6366","observed_orcids":["https://orcid.org/0000-0003-4331-6366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric R. Londin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056710242","display_name":"Joseph A. Cozzitorto","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joseph A. Cozzitorto","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086042240","display_name":"Carmella Romeo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmella Romeo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078078975","display_name":"Masaya Jimbo","orcid":"https://orcid.org/0000-0002-3181-3683","observed_orcids":["https://orcid.org/0000-0002-3181-3683"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Masaya Jimbo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036380544","display_name":"Zo\u00eb A. Norris","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zo\u00eb A. Norris","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025415933","display_name":"Charles J. Yeo","orcid":"https://orcid.org/0000-0001-8097-0071","observed_orcids":["https://orcid.org/0000-0001-8097-0071"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles J. Yeo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114045501","display_name":"Janet A. Sawicki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janet A. Sawicki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067354904","display_name":"Jordan Michael Winter","orcid":"https://orcid.org/0000-0002-5200-6557","observed_orcids":["https://orcid.org/0000-0002-5200-6557"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jordan M. Winter","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054046136","display_name":"Isidore Rigoutsos","orcid":"https://orcid.org/0000-0003-1529-8631","observed_orcids":["https://orcid.org/0000-0003-1529-8631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isidore Rigoutsos","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057472094","display_name":"Tim J. Yen","orcid":"https://orcid.org/0000-0003-2159-0997","observed_orcids":["https://orcid.org/0000-0003-2159-0997"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Timothy J. Yen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5079398934","display_name":"Jonathan Robert Brody","orcid":"https://orcid.org/0000-0003-3680-3270","observed_orcids":["https://orcid.org/0000-0003-3680-3270"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan R. Brody","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9351000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.017999999225139618,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hur","display_name":"HuR","score":0.9660000205039978},{"id":"https://openalex.org/keywords/wee1","display_name":"WEE1","score":0.9919999837875366},{"id":"https://openalex.org/keywords/post-transcriptional-regulation","display_name":"post-transcriptional regulation","score":0.9440000057220459},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.9539999961853027},{"id":"https://openalex.org/keywords/pancreatic-cancer","display_name":"pancreatic cancer","score":0.8159999847412109},{"id":"https://openalex.org/keywords/mrna-stability","display_name":"mRNA stability","score":0.5090000033378601},{"id":"https://openalex.org/keywords/cell-cycle-checkpoints","display_name":"cell cycle checkpoints","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.7740574479103088},{"id":"https://openalex.org/C2781252693","wikidata":"https://www.wikidata.org/wiki/Q7979264","display_name":"Wee1","level":5,"score":0.7547527551651001},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.6152210235595703},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5061134696006775},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.49525633454322815},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4470880329608917},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37082019448280334},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3467720150947571},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32848528027534485},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.32524001598358154},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.14068934321403503},{"id":"https://openalex.org/C120504264","wikidata":"https://www.wikidata.org/wiki/Q1147372","display_name":"Cyclin-dependent kinase 1","level":4,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1158/0008-5472.22401138","doi":"https://doi.org/10.1158/0008-5472.22401138","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22401138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"doi:10.1158/0008-5472.22401138.v1","doi":"https://doi.org/10.1158/0008-5472.22401138.v1","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22401138.v1","pdf_url":"https://aacr.figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_HuR_Posttranscriptionally_Regulates_WEE1_Implications_for_the_DNA_Damage_Response_in_Pancreatic_Cancer_Cells/22401138/1/files/39846918.pdf","source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},{"id":"pmh:oai:figshare.com:article/22401138","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/journal_contribution/Supplementary_Figure_5_from_HuR_Posttranscriptionally_Regulates_WEE1_Implications_for_the_DNA_Damage_Response_in_Pancreatic_Cancer_Cells/22401138","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1158/0008-5472.22401138","doi":"https://doi.org/10.1158/0008-5472.22401138","is_oa":true,"landing_page_url":"http://dx.doi.org/10.1158/0008-5472.22401138","pdf_url":null,"source":null,"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"American Association for Cancer Research","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4361895906.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2130287530","https://openalex.org/W4392686847","https://openalex.org/W2089818029","https://openalex.org/W2095508899","https://openalex.org/W2058869930","https://openalex.org/W2885767255","https://openalex.org/W4256493070","https://openalex.org/W2203127887","https://openalex.org/W4362461794","https://openalex.org/W3143582422"],"abstract_inverted_index":{"PDF":[0],"file":[1],"-":[2],"2070KB,":[3],"WEE1":[4],"is":[5],"post-transcriptionally":[6],"regulated":[7],"by":[8],"HuR":[9],"upon":[10],"DNA":[11],"damage.":[12]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2023-04-05T00:00:00"}